A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo. (Q34390813)

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11 February 2020

title

A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo (English)

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12

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Jianxing Song

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author name string

Aaron Petty

1

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11 February 2020

Eugene Myshkin

2

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Haina Qin

3

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11 February 2020

Hong Guo

4

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Hui Miao

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Gregory P Tochtrop

6

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Jer-Tsong Hsieh

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Phillip Page

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Lili Liu

9

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Daniel J Lindner

10

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11 February 2020

Chayan Acharya

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Eckhard Ficker

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Bingcheng Wang

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language of work or name

English

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publication date

15 August 2012

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11 February 2020

volume

7

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issue

8

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11 February 2020

page(s)

e42120

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Creative Commons Attribution 4.0 International

11 February 2020

copyright license

start time

15 August 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells

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EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt

6 July 2018

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Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex

6 July 2018

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Sending signals dynamically

6 July 2018

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LKB1; linking cell structure and tumor suppression

6 July 2018

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6 July 2018

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Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors

6 July 2018

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Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor

6 July 2018

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The current state of preclinical prostate cancer animal models

6 July 2018

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Constitutive activation of the Raf-MAPK pathway causes negative feedback inhibition of Ras-PI3K-AKT and cellular arrest through the EphA2 receptor

6 July 2018

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The alpha1-adrenergic receptor antagonist doxazosin inhibits EGFR and NF-kappaB signalling to induce breast cancer cell apoptosis

6 July 2018

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Dynamically driven protein allostery.

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Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity

6 July 2018

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Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin

6 July 2018

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Silencing of EphA3 through a cis interaction with ephrinA5.

6 July 2018

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EphA2 as a novel molecular marker and target in glioblastoma multiforme

6 July 2018

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A conditional feedback loop regulates Ras activity through EphA2.

6 July 2018

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Eph receptor signalling casts a wide net on cell behaviour

6 July 2018

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EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics.

6 July 2018

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6 July 2018

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Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases

6 July 2018

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Decreased tumorigenic potential of EphA2-overexpressing breast cancer cells following treatment with adenoviral vectors that express EphrinA1.

6 July 2018

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EphA2 expression is associated with aggressive features in ovarian carcinoma

6 July 2018

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Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasiveness

6 July 2018

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Efficient and accurate determination of the overall rotational diffusion tensor of a molecule from (15)N relaxation data using computer program ROTDIF.

6 July 2018

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Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling

6 July 2018

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Characterization of the overall and local dynamics of a protein with intermediate rotational anisotropy: Differentiating between conformational exchange and anisotropic diffusion in the B3 domain of protein G.

6 July 2018

1 reference

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Crystal structure of an Eph receptor-ephrin complex

6 July 2018

1 reference

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Chemical genetic approaches for the elucidation of signaling pathways

6 July 2018

1 reference

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DOCK 4.0: Search strategies for automated molecular docking of flexible molecule databases

6 July 2018

1 reference

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Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway

6 July 2018

1 reference

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Drug-like properties and the causes of poor solubility and poor permeability

6 July 2018

1 reference

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Multiple roles of EPH receptors and ephrins in neural development

6 July 2018

1 reference

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Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419725

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419725

Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee

6 July 2018

1 reference

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A geometric approach to macromolecule-ligand interactions

6 July 2018

1 reference

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Solvent-accessible surfaces of proteins and nucleic acids

6 July 2018

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Complete blockade by phenoxybenzamine of ?1- but not of ?2-vascular receptors in dogs and the effects of propranolol

6 July 2018

1 reference

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cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419725

EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma

6 July 2018

1 reference

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Mechanism of the prolonged adrenergic blockade produced by haloalkylamines.

27 October 2018

1 reference

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Chemometrical classification of ephrin ligands and Eph kinases using GRID/CPCA approach

27 October 2018

1 reference

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c-Cbl-dependent EphA2 protein degradation is induced by ligand binding.

27 October 2018

1 reference

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Quinazoline-derived alpha1-adrenoceptor antagonists induce prostate cancer cell apoptosis via an alpha1-adrenoceptor-independent action.

27 October 2018

1 reference

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Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis

27 October 2018

1 reference

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EphA2 overexpression causes tumorigenesis of mammary epithelial cells.

27 October 2018

1 reference

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The main-chain dynamics of the dynamin pleckstrin homology (PH) domain in solution: analysis of 15N relaxation with monomer/dimer equilibration 1 1 Edited by P.E.Wright

27 October 2018

1 reference

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Purification, crystallization and preliminary characterization of an Eph-B2/ephrin-B2 complex

9 December 2018

1 reference

12 December 2020

Transforming growth factor beta 1 transduced mouse prostate reconstitutions: II. Induction of apoptosis by doxazosin

1 reference

12 December 2020

PTPases: "Eph" ective arbitrators of attraction

1 reference

12 December 2020

Alpha-1 adrenoceptor selectivity of phenoxybenzamine in the rat kidney

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0042120

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11 February 2020

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11 February 2020

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