Orthomolecular oncology review: ascorbic acid and cancer 25 years later (Q34391627)

1 August 2017

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title

Orthomolecular oncology review: ascorbic acid and cancer 25 years later (English)

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1 August 2017

Michael J González

1

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1 August 2017

Jorge R Miranda-Massari

2

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1 August 2017

Edna M Mora

3

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1 August 2017

Angelik Guzmán

4

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1 August 2017

Neil H Riordan

5

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1 August 2017

Hugh D Riordan

6

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1 August 2017

Joseph J Casciari

7

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1 August 2017

James A Jackson

8

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1 August 2017

Angel Román-Franco

9

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1 August 2017

1 March 2005

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Integrative Cancer Therapies

1 August 2017

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1 August 2017

4

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1 August 2017

1

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1 August 2017

32-44

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New concepts in the biology and biochemistry of ascorbic acid

1 August 2017

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https://api.crossref.org/works/10.1177%2F1534735404273861

Bioenergetics and mitochondrial transmembrane potential during differentiation of cultured osteoblasts.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

Vitamin C as an antioxidant: evaluation of its role in disease prevention

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

Ascorbate is an outstanding antioxidant in human blood plasma

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

The cooperative action of vitamins E and C in the protection against peroxidation of parinaric acid in human erythrocyte membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Direct observation of a free radical interaction between vitamin E and vitamin C

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Biokinetics of dietary RRR-alpha-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E. Evidence that vitamin C does not "spare" vitamin E in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

The effect of ascorbic acid on the glycolytic and respiratory metabolism of embryonic chick tibias

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

Dehydroascorbic acid and cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Vitamin C preferential toxicity for malignant melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

Role of ascorbate in the activation of NF-kappaB by tumour necrosis factor-alpha in T-cells

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

Vitamin C: antioxidant or pro-oxidant in vivo?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Ascorbate on cell growth and differentiation.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

Hydrogen peroxide cytotoxicity. Low-temperature enhancement by ascorbate or reduced lipoate

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

The in vitro cytotoxicity of ascorbate depends on the culture medium used to perform the assay and involves hydrogen peroxide

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

Lipid peroxidation and tumor growth: an inverse relationship

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

The paradoxical role of lipid peroxidation on carcinogenesis and tumor growth: a commentary

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

A unique function for ascorbate

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

Mitochondrial uptake and recycling of ascorbic acid

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

Fish oil, lipid peroxidation and mammary tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Effect of metal ions on the kinetics of tyrosine oxidation catalysed by tyrosinase

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

Antioxidant enzyme activities and oxidative stress in human breast cancer.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

Depression of catalase gene expression after immortalization and transformation of mouse liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Effects of sodium ascorbate (vitamin C) and 2-methyl-1,4-naphthoquinone (vitamin K3) treatment on human tumor cell growth in vitro. I. Synergism of combined vitamin C and K3 action

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Ultrastructural aspects of autoschizis: a new cancer cell death induced by the synergistic action of ascorbate/menadione on human bladder carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Autoschizis: a novel cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fibre in vitro tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

The role of ascorbic acid in senile cataract

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Ascorbate recycling in human neutrophils: induction by bacteria

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

On the Origin of Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Evaluating the physician office visit: in pursuit of a valid and reliable measure of quality improvement efforts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Ascorbate-induced differentiation of embryonic cortical precursors into neurons and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Dysfunctional mitochondria, not oxygen insufficiency, cause cancer cells to produce inordinate amounts of lactic acid: the impact of this on the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Ascorbic acid and the glycosaminoglycans. An orthomolecular approach to cancer and other diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Vitamin C and human wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Enhancement of random migration and chemotactic response of human leukocytes by ascorbic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Ascorbate-Nitrite Reaction: Possible Means of Blocking the Formation of Carcinogenic N -Nitroso Compounds

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

Effect of vitamin C and vitamin E on prostaglandin synthesis by fibroblasts and squamous carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Vitamin C augments chemotherapeutic response of cervical carcinoma HeLa cells by stabilizing P53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Vitamin C, titrating to bowel tolerance, anascorbemia, and acute induced scurvy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Acute haemolysis induced by high dose ascorbic acid in glucose-6-phosphate dehydrogenase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

No contribution of ascorbic acid to renal calcium oxalate stones

21 January 2018

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https://api.crossref.org/works/10.1177%2F1534735404273861

Effect of high dose vitamin C on urinary oxalate levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Vitamin C: the nontoxic, nonrate-limited, antioxidant free radical scavenger

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Acute Reactions to Mega Ascorbic Acid Therapy in Malignant Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Vitamin C enhances the development of carcinomas in the hamster buccal pouch experimental model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Ascorbic acid and gastrointestinal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Pros and cons of antioxidant use during radiation therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

The use of antioxidants with first-line chemotherapy in two cases of ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

High doses of multiple antioxidant vitamins: essential ingredients in improving the efficacy of standard cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Cisplatin combination chemotherapy induces a fall in plasma antioxidants of cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

Enhancement of interferon production by poly(rI)·poly(rC) in mouse cell cultures by ascorbic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735404273861

21 January 2018

Identifiers

DOI

10.1177/1534735404273861

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1 August 2017

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