Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia (Q34392488)

1 August 2017

title

Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia (English)

1 reference

1 August 2017

1 reference

1 reference

20

Markus Müschen

0 references

Rongqing Pan

object named as

Rongqing Pan

1

0 references

Patrick A Zweidler-McKay

object named as

Patrick Zweidler-McKay

27

0 references

Hagop Kantarjian

29

object named as

Hagop Kantarjian

1 reference

1 August 2017

7

Jorge Cortes

1 reference

1 August 2017

15

Torsten Haferlach

1 reference

1 August 2017

19

Guido Marcucci

1 reference

1 August 2017

6

Gautam Borthakur

1 reference

1 August 2017

31

Marina Konopleva

1 reference

1 August 2017

11

Hartmut Döhner

1 reference

1 August 2017

30

Michael Andreeff

1 reference

1 August 2017

23

Peter P Ruvolo

1 reference

1 August 2017

3

Juliana M Benito

1 reference

1 August 2017

2

Leah J Hogdal

1 reference

1 August 2017

8

Daniel J DeAngelo

1 reference

1 August 2017

14

Leonard S Golfman

1 reference

1 August 2017

18

Joel D Leverson

1 reference

1 August 2017

24

Vivian Ruvolo

1 reference

1 August 2017

5

Lina Han

1 reference

1 August 2017

13

Ilene Galinsky

1 reference

1 August 2017

Donna Bucci

4

1 reference

1 August 2017

Lakeisha Debose

9

1 reference

1 August 2017

Hong Mu

10

1 reference

1 August 2017

Verena I Gaidzik

12

1 reference

1 August 2017

Karine G Harutyunyan

16

1 reference

1 August 2017

Jianhua Hu

17

1 reference

1 August 2017

Markus Müschen

20

1 reference

1 August 2017

Rachel Newman

21

1 reference

1 August 2017

Eugene Park

22

1 reference

1 August 2017

Jeremy Ryan

25

1 reference

1 August 2017

Sonja Schindela

26

1 reference

1 August 2017

Richard M Stone

28

1 reference

1 August 2017

Anthony G Letai

32

1 reference

1 August 2017

publication date

17 December 2013

1 reference

1 August 2017

1 reference

1 August 2017

volume

4

1 reference

1 August 2017

issue

3

1 reference

1 August 2017

page(s)

362-375

1 reference

Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer

1 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Role for PKC δ in Fenretinide-Mediated Apoptosis in Lymphoid Leukemia Cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Bcl-2-family proteins and the role of mitochondria in apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975047

10.1158/2159-8290.CD-13-0609

27 October 2018

Identifiers

DOI

1 reference

1 August 2017

1 reference

1 August 2017

1 reference