The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans. (Q34400605)

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19 October 2019

title

The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans (English)

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19 October 2019

4

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19 October 2019

author name string

Capon DA

1

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19 October 2019

Bochner F

2

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19 October 2019

Kerry N

3

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19 October 2019

Danz C

5

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19 October 2019

Somogyi AA

6

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19 October 2019

language of work or name

English

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publication date

1 September 1996

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Clinical Pharmacology & Therapeutics

19 October 2019

published in

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19 October 2019

volume

60

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19 October 2019

issue

3

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19 October 2019

page(s)

295-307

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Dextromethorphan and codeine: objective assessment of antitussive activity in patients with chronic cough

19 October 2019

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Sparteine oxidation is practically abolished in quinidine-treated patients

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Quinidine: potent inhibition of sparteine and debrisoquine oxidation in vivo.

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Quinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of debrisoquine

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The urinary excretion of dextromethorphan and three metabolites in dogs and humans

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Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation

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Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis.

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The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects

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Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs

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Single-dose quinidine treatment inhibits mexiletine oxidation in extensive metabolizers of debrisoquine

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Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers

7 January 2021

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Dextromethorphan: enhancing its systemic availability by way of low-dose quinidine-mediated inhibition of cytochrome P4502D6.

7 January 2021

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Phenotypic differences in dextromethorphan metabolism

7 January 2021

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Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 db1 activity

7 January 2021

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Dextromethorphan metabolism in rat: interstrain differences and the fate of individually administered oxidative metabolites

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7 January 2021

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7 January 2021

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7 January 2021

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Comparison of the antitussive effects of codeine phosphate 20 mg, dextromethorphan 30 mg and noscapine 30 mg using citric acid-induced cough in normal subjects

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Increased cough reflex associated with angiotensin converting enzyme inhibitor cough

7 January 2021

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inferred from DOI database lookup

7 January 2021

based on heuristic

Peripheral opioid receptors and the cough reflex

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0009-9236(96)90056-9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8841152%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

1 reference