Disulfide linkage engineering for improving biophysical properties of human VH domains (Q34401520)

1 August 2017

title

Disulfide linkage engineering for improving biophysical properties of human VH domains (English)

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1 August 2017

Dae Young Kim

1

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1 August 2017

Hiba Kandalaft

2

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1 August 2017

Wen Ding

3

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1 August 2017

Shannon Ryan

4

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1 August 2017

Henk van Faassen

5

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1 August 2017

Tomoko Hirama

6

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1 August 2017

Simon J Foote

7

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1 August 2017

Roger MacKenzie

8

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1 August 2017

Jamshid Tanha

9

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1 August 2017

publication date

30 August 2012

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Protein Engineering Design and Selection

1 August 2017

published in

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1 August 2017

volume

25

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1 August 2017

issue

10

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1 August 2017

page(s)

581-589

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Three-Dimensional Structure of Immunoglobulins

1 August 2017

cites work

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Aggregation-resistant VHs selected by in vitro evolution tend to have disulfide-bonded loops and acidic isoelectric points

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Crystal Structure of a Human Single Domain Antibody Dimer Formed through VH-VH Non-Covalent Interactions

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Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains

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21 January 2018

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Disulfide bonds and the stability of globular proteins

21 January 2018

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Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils

21 January 2018

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New algorithm for the identification of intact disulfide linkages based on fragmentation characteristics in tandem mass spectra.

21 January 2018

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Repertoires of aggregation-resistant human antibody domains

21 January 2018

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Effects of disulfide bond formation and protein helicity on the aggregation of activating transcription factor 5

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Single antibody domains as small recognition units: design and in vitro antigen selection of camelized, human VH domains with improved protein stability

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General strategy for the generation of human antibody variable domains with increased aggregation resistance

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Thermodynamically stable aggregation-resistant antibody domains through directed evolution

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21 January 2018

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Protein drug stability: a formulation challenge

21 January 2018

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Engineered human antibody constant domains with increased stability

21 January 2018

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The Role of the Intrachain Disulfide Bond in the Conformation and Stability of the Constant Fragment of the Immunoglobulin Light Chain1

21 January 2018

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Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity

21 January 2018

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Stabilization of an immunoglobulin fold domain by an engineered disulfide bond at the buried hydrophobic region

21 January 2018

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A role for destabilizing amino acid replacements in light-chain amyloidosis

21 January 2018

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Engineered single-domain antibodies with high protease resistance and thermal stability

21 January 2018

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Double-hexahistidine tag with high-affinity binding for protein immobilization, purification, and detection on ni-nitrilotriacetic acid surfaces.

21 January 2018

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Extreme stabilization of a thermolysin-like protease by an engineered disulfide bond

21 January 2018

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Affinity selection of a camelized V(H) domain antibody inhibitor of hepatitis C virus NS3 protease

21 January 2018

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The influence of intramolecular bridges on the dynamics of a protein folding reaction

21 January 2018

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Amino acid substitutions influencing intracellular protein folding pathways

21 January 2018

1 reference

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BIACORE analysis of histidine-tagged proteins using a chelating NTA sensor chip.

21 January 2018

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Disulfide bond introduction for general stabilization of immunoglobulin heavy-chain variable domains

21 January 2018

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Antibody variable region binding by Staphylococcal protein A: thermodynamic analysis and location of the Fv binding site on E-domain

21 January 2018

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Isolation of monomeric human V(H)s by a phage selection

21 January 2018

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Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli

21 January 2018

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Mutations and off-pathway aggregation of proteins

21 January 2018

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Disulfide bonds and thermal stability in T4 lysozyme

21 January 2018

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The immunoglobulin superfamily--domains for cell surface recognition

21 January 2018

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Stability engineering of antibody single-chain Fv fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS055

Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS055

Mass spectrometric determination of disulfide linkages in recombinant therapeutic proteins using online LC-MS with electron-transfer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS055

Thermal stabilization of a single-chain Fv antibody fragment by introduction of a disulphide bond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS055

Antibody scFv fragments without disulfide bonds made by molecular evolution

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS055

Substantial increase of protein stability by multiple disulphide bonds

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS055

21 January 2018

Identifiers

DOI

10.1093/PROTEIN/GZS055

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1 August 2017

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