Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs. (Q34403287)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22948871%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs (English)

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12 February 2020

1

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12 February 2020

author name string

Emma Louise Meredith

series ordinal

2

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12 February 2020

Shane R Wilkinson

series ordinal

3

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12 February 2020

language of work or name

English

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publication date

4 September 2012

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12 February 2020

number of pages

10

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Antimicrobial Agents and Chemotherapy

inferred from page(s)

published in

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12 February 2020

volume

56

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12 February 2020

issue

11

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12 February 2020

page(s)

5821-5830

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High-throughput decoding of antitrypanosomal drug efficacy and resistance

12 February 2020

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Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation

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Identification, cloning and characterization of an aldo-keto reductase from Trypanosoma cruzi with quinone oxido-reductase activity.

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6 July 2018

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Design of anticancer prodrugs for reductive activation.

6 July 2018

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6 July 2018

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A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

6 July 2018

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A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides

6 July 2018

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6 July 2018

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The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase of Trypanosomatidae and the glycosomal redox balance of insect stages of Trypanosoma brucei and Leishmania spp.

6 July 2018

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Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects

6 July 2018

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Preclinical evaluation of the pharmacodynamic properties of 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone

6 July 2018

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Natural products active against African trypanosomes: a step towards new drugs.

6 July 2018

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Evidence for lateral transfer of genes encoding ferredoxins, nitroreductases, NADH oxidase, and alcohol dehydrogenase 3 from anaerobic prokaryotes to Giardia lamblia and Entamoeba histolytica

6 July 2018

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A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi

6 July 2018

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Identification of a Mycobacterium tuberculosis putative classical nitroreductase gene whose expression is coregulated with that of the acr aene within macrophages, in standing versus shaking cultures, and under low oxygen conditions.

6 July 2018

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6 July 2018

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Regulation of genes encoding NAD(P)H:quinone oxidoreductases

6 July 2018

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Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme

6 July 2018

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Oxygen-insensitive nitroreductases: analysis of the roles of nfsA and nfsB in development of resistance to 5-nitrofuran derivatives in Escherichia coli.

6 July 2018

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Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium

6 July 2018

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Gene cloning, purification, and characterization of NfsB, a minor oxygen-insensitive nitroreductase from Escherichia coli, similar in biochemical properties to FRase I, the major flavin reductase in Vibrio fischeri

6 July 2018

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Biochemical characterization of NfsA, the Escherichia coli major nitroreductase exhibiting a high amino acid sequence homology to Frp, a Vibrio harveyi flavin oxidoreductase

6 July 2018

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A rapid micromethod for determination of FMN and FAD in mixtures.

6 July 2018

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"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease

6 July 2018

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Posttranscriptional regulation of cytochrome c expression during the developmental cycle of Trypanosoma brucei

6 July 2018

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Respiration of bloodstream forms of the parasite Trypanosoma brucei brucei is dependent on a plant-like alternative oxidase

6 July 2018

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Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers

6 July 2018

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Free radical formation by antitumor quinones

6 July 2018

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Purification and characterization of an oxygen-insensitive NAD(P)H nitroreductase from Enterobacter cloacae

6 July 2018

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Molecular mechanisms of quinone cytotoxicity

6 July 2018

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Oxygen-sensitive and -insensitive nitroreduction by Escherichia coli and rat hepatic microsomes

6 July 2018

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Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs.

6 July 2018

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Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs.

27 October 2018

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Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954.

27 October 2018

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Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954.

27 October 2018

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Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.

27 October 2018

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Identification of a gene encoding a 54 kDa alternative NADH dehydrogenase in Trypanosoma brucei

27 October 2018

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Rotenone-insensitive NADH dehydrogenase is a potential source of superoxide in procyclic Trypanosoma brucei mitochondria

27 October 2018

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Two-electron reduction of quinones by Enterobacter cloacae NAD(P)H:nitroreductase: quantitative structure-activity relationships

27 October 2018

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Novel FMN-containing rotenone-insensitive NADH dehydrogenase from Trypanosoma brucei mitochondria: isolation and characterization

27 October 2018

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Isolation and characterization of complex I, rotenone-sensitive NADH: ubiquinone oxidoreductase, from the procyclic forms of Trypanosoma brucei

27 October 2018

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Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase

27 October 2018

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Protein stability regulates the expression of cytochrome c during the developmental cycle of Trypanosoma brucei.

27 October 2018

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Studies on oxygen-insensitive nitrofuran reductase in Escherichia coli B/r.

27 October 2018

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Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1

27 October 2018

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Human African trypanosomiasis

9 December 2018

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An Estimate of the Burden of Chagas Disease in the United States

9 December 2018

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One-electron-transfer reactions in biochemical systems. V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase)

9 December 2018

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12 December 2020

Non-cytochrome mediated mitochondrial ATP production in bloodstream form Trypanosoma brucei brucei

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12 December 2020

Active site studies of DT-diaphorase employing artificial flavins

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12 December 2020

Steady-state kinetic mechanism, stereospecificity, substrate and inhibitor specificity of Enterobacter cloacae nitroreductase

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12 December 2020

DT diaphorase. I. Purification from the soluble fraction of rat-liver cytoplasm, and properties

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12 December 2020

THE MOLAR EXTINCTION COEFFICIENT OF 2,6-DICHLOROPHENOL INDOPHENOL

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12 December 2020

Validation of the comet-X assay as a pharmacodynamic assay for measuring DNA cross-linking produced by the novel anticancer agent RH1 during a phase I clinical trial

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12 December 2020

Identifiers

DOI

10.1128/AAC.01227-12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22948871%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22948871%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

22948871

1 reference