Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms (Q34408068)

2 August 2017

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title

Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms (English)

1 reference

2 August 2017

Roche TE

1

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2 August 2017

Baker JC

2

1 reference

2 August 2017

Yan X

3

1 reference

2 August 2017

Hiromasa Y

4

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2 August 2017

Gong X

5

1 reference

2 August 2017

Peng T

6

1 reference

2 August 2017

Dong J

7

1 reference

2 August 2017

Turkan A

8

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2 August 2017

Kasten SA

9

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2 August 2017

publication date

1 January 2001

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Progress in Molecular Biology and Translational Science

2 August 2017

published in

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2 August 2017

volume

70

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2 August 2017

page(s)

33-75

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Fuel selection in animals

2 August 2017

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7 January 2021

Molecular cloning and expression of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase and sequence similarity with protein phosphatase 2C

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7 January 2021

Cloning, expression, and properties of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase

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Marked differences between two isoforms of human pyruvate dehydrogenase kinase

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7 January 2021

-Keto acid dehydrogenase complexes. XVII. Kinetic and regulatory properties of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase from bovine kidney and heart

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Function of calcium ions in pyruvate dehydrogenase phosphatase activity

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Evidence for lipoic acid mediated NADH and acetyl-CoA stimulation of liver and kidney pyruvate dehydrogenase kinase

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7 January 2021

Purification and properties of pyruvate dehydrogenase phosphatase from bovine heart and kidney

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Purification of Bovine Kidney and Heart Pyruvate Dehydrogenaseb Phosphatase on Sepharose Derivatized with the Pyruvate Dehydrogenase Complex

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7 January 2021

Additional binding sites for the pyruvate dehydrogenase kinase but not for protein X in the assembled core of the mammalian pyruvate dehydrogenase complex: binding region for the kinase

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7 January 2021

Binding of the pyruvate dehydrogenase kinase to recombinant constructs containing the inner lipoyl domain of the dihydrolipoyl acetyltransferase component

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7 January 2021

Activated function of the pyruvate dehydrogenase phosphatase through Ca2+-facilitated binding to the inner lipoyl domain of the dihydrolipoyl acetyltransferase

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7 January 2021

Assembly and full functionality of recombinantly expressed dihydrolipoyl acetyltransferase component of the human pyruvate dehydrogenase complex

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7 January 2021

Requirements for the adaptor protein role of dihydrolipoyl acetyltransferase in the up-regulated function of the pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase

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7 January 2021

Lipoyl domain-based mechanism for the integrated feedback control of the pyruvate dehydrogenase complex by enhancement of pyruvate dehydrogenase kinase activity.

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7 January 2021

Regulation of mammalian pyruvate dehydrogenase kinase.

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7 January 2021

Molecular biology and biochemistry of pyruvate dehydrogenase complexes.

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7 January 2021

Stoichiometry, organisation and catalytic function of protein X of the pyruvate dehydrogenase complex from bovine heart

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7 January 2021

Nucleotide sequence of a cDNA for the dihydrolipoamide acetyltransferase component of human pyruvate dehydrogenase complex

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7 January 2021

Disruption and mutagenesis of the Saccharomyces cerevisiae PDX1 gene encoding the protein X component of the pyruvate dehydrogenase complex

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7 January 2021

Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex

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7 January 2021

Site-directed mutagenesis and 1H NMR spectroscopy of an interdomain segment in the pyruvate dehydrogenase multienzyme complex of Escherichia coli.

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7 January 2021

2-Oxo acid dehydrogenase multienzyme complexes: domains, dynamics, and design

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7 January 2021

Expression, purification, and characterization of the dihydrolipoamide dehydrogenase-binding protein of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae

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7 January 2021

Role of protein X in the function of the mammalian pyruvate dehydrogenase complex

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Reconstitution of mammalian pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes: analysis of protein X involvement and interaction of homologous and heterologous dihydrolipoamide dehydrogenases

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7 January 2021

Sizing of bovine heart and kidney pyruvate dehydrogenase complex and dihydrolipoyl transacetylase core by quasielastic light scattering.

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7 January 2021

Elementary steps in the reaction of the pyruvate dehydrogenase complex from pig heart. Kinetics of thiamine diphosphate binding to the complex

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7 January 2021

Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex

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7 January 2021

Crystallographic analysis of substrate binding and catalysis in dihydrolipoyl transacetylase (E2p)

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7 January 2021

Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes

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7 January 2021

Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease

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7 January 2021

X-ray structure of lipoamide dehydrogenase from Azotobacter vinelandii determined by a combination of molecular and isomorphous replacement techniques

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7 January 2021

The refined crystal structure of Pseudomonas putida lipoamide dehydrogenase complexed with NAD+ at 2.45 A resolution

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7 January 2021

The relationships between transketolase, yeast pyruvate decarboxylase and pyruvate dehydrogenase of the pyruvate dehydrogenase complex.

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7 January 2021

Identification of the tryptophan residue in the thiamin pyrophosphate binding site of mammalian pyruvate dehydrogenase

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7 January 2021

Specificity determinants for the pyruvate dehydrogenase component reaction mapped with mutated and prosthetic group modified lipoyl domains

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7 January 2021

Reaction mechanism for mammalian pyruvate dehydrogenase using natural lipoyl domain substrates

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7 January 2021

Reversible phosphorylation of pyruvate dehydrogenase in rat skeletal-muscle mitochondria. Effects of starvation and diabetes

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7 January 2021

Longer-term regulation of pyruvate dehydrogenase kinase in cultured rat hepatocytes

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7 January 2021

Cyclic AMP and free fatty acids in the longer-term regulation of pyruvate dehydrogenase kinase in rat soleus muscle

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7 January 2021

Glucose utilization in heart, diaphragm and skeletal muscle during the fed-to-starved transition

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7 January 2021

Molecular mechanisms underlying the long-term impact of dietary fat to increase cardiac pyruvate dehydrogenase kinase: regulation by insulin, cyclic AMP and pyruvate

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7 January 2021

Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression

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7 January 2021

Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding

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7 January 2021

Kinase activator protein mediates longer-term effects of starvation on activity of pyruvate dehydrogenase kinase in rat liver mitochondria

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7 January 2021

Insulin reverses effects of starvation on the activity of pyruvate dehydrogenase kinase in cultured hepatocytes

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7 January 2021

Hepatic pyruvate dehydrogenase kinase activities during the starved-to-fed transition

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7 January 2021

Regulation of hepatic pyruvate dehydrogenase kinase by insulin and dietary manipulation in vivo. Studies with the euglycaemic-hyperinsulinaemic clamp

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7 January 2021

Studies of the long-term regulation of hepatic pyruvate dehydrogenase kinase

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7 January 2021

The disposition of carbohydrate between glycogenesis, lipogenesis and oxidation in liver during the starved-to-fed transition

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7 January 2021

The role of regulation of tissue pyruvate dehydrogenase complex activity during the starved-to-fed transition

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7 January 2021

Substrate interactions in the short- and long-term regulation of renal glucose oxidation.

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7 January 2021

Effect of Insulin on Fatty Acid Synthesis from Pyuvate, Lactate, or Endogenous Sources in Adipose Tissue: Evidence for the Hormonal Regulation of Pyruvate Dehydrogenase1

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7 January 2021

Insulin, phospholipase, and the activation of the pyruvate dehydrogenase complex: an enigma

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7 January 2021

Regulation by insulin and free fatty acids of pyruvate dehydrogenase activity in perfused rat liver [proceedings]

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7 January 2021

Parallel increases in rates of fatty acid synthesis and in pyruvate dehydrogenase activity in isolated rat hepatocytes incubated with insulin

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7 January 2021

Absent pyruvate inhibition of pyruvate dehydrogenase kinase in lactating rat mammary gland following various treatments. Removal of circulating insulin and prolactin and exposure to protein synthesis inhibitors

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7 January 2021

Evidence that fatty acid synthesis in the interscapular brown adipose tissue of cold-adapted rats is increased in vivo by insulin by mechanisms involving parallel activation of pyruvate dehydrogenase and acetyl-coenzyme A carboxylase

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7 January 2021

Regulation of fatty acid synthesis and esterification in rat epididymal adipose tissue: effects of insulin, palmitate and 2-bromopalmitate [proceedings]

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7 January 2021

Persistence of the effect of insulin on pyruvate dehydrogenase activity in rat white and brown adipose tissue during the preparation and subsequent incubation of mitochondria

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7 January 2021

Sensitivity of pyruvate dehydrogenase phosphate phosphatase to magnesium ions. Similar effects of spermine and insulin

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7 January 2021

Studies into the mechanism whereby insulin activates pyruvate dehydrogenase complex in adipose tissue

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7 January 2021

Use of toluene-permeabilized mitochondria to study the regulation of adipose tissue pyruvate dehydrogenase in situ. Further evidence that insulin acts through stimulation of pyruvate dehydrogenase phosphate phosphatase

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7 January 2021

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

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7 January 2021

Ca2+ as a second messenger within mitochondria of the heart and other tissues

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7 January 2021

The hormonal regulation of pyruvate dehydrogenase complex

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7 January 2021

Dehydrogenase activation by Ca2+ in cells and tissues

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7 January 2021

Development of mitochondrial energy metabolism in rat brain

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7 January 2021

The Development of Enzymes of Energy Metabolism in the Brain of a Precocial (Guinea Pig) and Non-Precocial (Rat) Species

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7 January 2021

Regional enzyme development in rat brain. Enzymes of energy metabolism

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7 January 2021

Comparative development of the pyruvate dehydrogenase complex and citrate synthase in rat brain mitochondria

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7 January 2021

"Cerebral" lactic acidosis: defects in pyruvate metabolism with profound brain damage and minimal systemic acidosis

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7 January 2021

The clinical and biochemical spectrum of human pyruvate dehydrogenase complex deficiency

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7 January 2021

Abnormalities of pyruvate dehydrogenase complex in brain disease

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7 January 2021

Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios

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7 January 2021

Monovalent cation requirement for ADP inhibition of pyruvate dehydrogenase kinase

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7 January 2021

Sites of phosphorylation on pyruvate dehydrogenase from bovine kidney and heart

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7 January 2021

Amino acid sequences around the sites of phosphorylation in the pig heart pyruvate dehydrogenase complex

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7 January 2021

Function of phosphorylation sites on pyruvate dehydrogenase

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7 January 2021

Dephosphorylation of pig heart pyruvate dehydrogenase phosphate complexes by pig heart pyruvate dehydrogenase phosphate phosphatase

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7 January 2021

Role of individual phosphorylation sites in inactivation of pyruvate dehydrogenase complex in rat heart mitochondria

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7 January 2021

Occupancy of phosphorylation sites in pyruvate dehydrogenase phosphate complex in rat heart in vivo. Relation to proportion of inactive complex and rate of re-activation by phosphatase

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7 January 2021

Spectroscopic studies of the characterization of recombinant human dihydrolipoamide dehydrogenase and its site-directed mutants.

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7 January 2021

Stimulation of pyruvate dehydrogenase phosphatase activity by polyamines

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7 January 2021

Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

Integrating cytosolic calcium signals into mitochondrial metabolic responses

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

Purification of porcine liver pyruvate dehydrogenase complex and characterization of its catalytic and regulatory properties

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7 January 2021

Insulin-stimulated hydrolysis of a novel glycolipid generates modulators of cAMP phosphodiesterase

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7 January 2021

"Stable" effects of insulin and isoproterenol on adipocyte pyruvate dehydrogenase

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7 January 2021

Partial structure of an insulin-sensitive glycophospholipid

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7 January 2021

Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphate contains galactosamine and D-chiroinositol.

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7 January 2021

Insulin mediators and the control of pyruvate dehydrogenase complex

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7 January 2021

Interconversion and kinetic properties of pyruvate dehydrogenase from brain.

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7 January 2021

The mode of regulation of pyruvate dehydrogenase of lactating rat mammary gland. Effects of starvation and insulin

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

Studies on the regulation of the mitochondrial alpha-ketoacid dehydrogenase complexes and their kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

Molecular cloning, functional expression, and characterization of pyruvate dehydrogenase kinase from anaerobic muscle of the parasitic nematode Ascaris suum

1 reference

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7 January 2021

Nematode pyruvate dehydrogenase kinases: role of the C-terminus in binding to the dihydrolipoyl transacetylase core of the pyruvate dehydrogenase complex

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7 January 2021

Molecular analysis of two pyruvate dehydrogenase kinases from maize.

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7 January 2021

Pyruvate dehydrogenase kinase from Arabidopsis thaliana: a protein histidine kinase that phosphorylates serine residues

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7 January 2021

Expression and characterization of branched-chain alpha-ketoacid dehydrogenase kinase from the rat. Is it a histidine-protein kinase?

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7 January 2021

Communication modules in bacterial signaling proteins

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7 January 2021

Structure of CheA, a signal-transducing histidine kinase

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7 January 2021

NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ

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7 January 2021

Crystal structure of an N-terminal fragment of the DNA gyrase B protein.

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7 January 2021

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

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7 January 2021

Three-dimensional solution structure of the E3-binding domain of the dihydrolipoamide succinyltransferase core from the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli.

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7 January 2021

Three-dimensional structure of the major autoantigen in primary biliary cirrhosis

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

Basement membrane research in diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

Dehydroepiandrosterone protects bovine retinal capillary pericytes against glucose toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

Effects of dichloroacetate on the metabolism of glucose, pyruvate, acetate, 3-hydroxybutyrate and palmitate in rat diaphragm and heart muscle in vitro and on extraction of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

Glycolysis and glucose oxidation during reperfusion of ischemic hearts from diabetic rats

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A a

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

Suppression of beta-oxidation restores pyruvate inhibition of pyruvate dehydrogenase kinase in starved rat heart

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides are orally active inhibitors of pyruvate dehydrogenase kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK).

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

Specificity of the pyruvate dehydrogenase kinase for pyruvate dehydrogenase component bound to the surface of the kidney pyruvate dehydrogenase complex and evidence for intracore migration of pyruvate dehydrogenase component

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

Complexes of sequential metabolic enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

One-step purification of the recombinant catalytic subunit of pyruvate dehydrogenase phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2970013-X

7 January 2021

10.1016/S0079-6603(01)70013-X

Identifiers

DOI

1 reference

2 August 2017

1 reference