Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model (Q34411761)

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English	Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model	scientific article

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12 March 2020

Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model (English)

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12 March 2020

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prostate cancer

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1

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12 March 2020

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J C Yang

2

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12 March 2020

H-J Kung

3

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12 March 2020

X-B Shi

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12 March 2020

D Tilki

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12 March 2020

P N Lara

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12 March 2020

R W DeVere White

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12 March 2020

A C Gao

8

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12 March 2020

C P Evans

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24 March 2014

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12 March 2020

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12 March 2020

33

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12 March 2020

36

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12 March 2020

4521-4530

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12 March 2020

copyright license

Creative Commons Attribution 3.0 Unported

24 March 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

https://scigraph.springernature.com/pub.10.1038/onc.2014.25

0 references

An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide).

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6 July 2018

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

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6 July 2018

NF-κB2/p52 induces resistance to enzalutamide in prostate cancer: role of androgen receptor and its variants

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6 July 2018

Androgen deprivation and androgen receptor competition by bicalutamide induce autophagy of hormone-resistant prostate cancer cells and confer resistance to apoptosis

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6 July 2018

Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines

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6 July 2018

Guidelines for the use and interpretation of assays for monitoring autophagy

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6 July 2018

Does androgen-ablation therapy (AAT) associated autophagy have a pro-survival effect in LNCaP human prostate cancer cells?

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6 July 2018

Increased survival with enzalutamide in prostate cancer after chemotherapy

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6 July 2018

Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro.

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Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma

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Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

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Metformin inhibits melanoma development through autophagy and apoptosis mechanisms.

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6 July 2018

Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth

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6 July 2018

Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer

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6 July 2018

AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia

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6 July 2018

Targeting tyrosine kinases and autophagy in prostate cancer

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6 July 2018

The association of AMPK with ULK1 regulates autophagy

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6 July 2018

Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells

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6 July 2018

Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells

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Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux

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Deregulated Aurora-B induced tetraploidy promotes tumorigenesis

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6 July 2018

ADI, autophagy and apoptosis: metabolic stress as a therapeutic option for prostate cancer

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6 July 2018

AMPK phosphorylation of raptor mediates a metabolic checkpoint

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6 July 2018

Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy

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Tricyclic antidepressant pharmacology and therapeutic drug interactions updated

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Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

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Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial

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Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property

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TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

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The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

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Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors

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Autophagy protects LNCaP cells under androgen deprivation conditions

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Words of wisdom: re: androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines

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Targeting androgen receptor leads to suppression of prostate cancer via induction of autophagy

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31 March 2020

The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

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31 March 2020

The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

1 reference

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12 December 2020

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10.1038/ONC.2014.25

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12 March 2020

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12 March 2020

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12 March 2020

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