Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ. (Q34414231)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20735016%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ (English)

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11 February 2020

8

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11 February 2020

author name string

Yongjun Wang

1

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11 February 2020

Naresh Kumar

2

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11 February 2020

Philippe Nuhant

3

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11 February 2020

Michael D Cameron

4

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11 February 2020

Monica A Istrate

5

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11 February 2020

William R Roush

6

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11 February 2020

Patrick R Griffin

7

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11 February 2020

publication date

1 November 2010

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11 February 2020

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11 February 2020

volume

5

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11 February 2020

issue

11

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11 February 2020

page(s)

1029-1034

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Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics

11 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

Regulation of adipogenesis by natural and synthetic REV-ERB ligands.

6 July 2018

1 reference

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Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.

6 July 2018

1 reference

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6 July 2018

1 reference

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Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

A natural product ligand of the oxysterol receptor, liver X receptor.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

Role of LXRs in control of lipogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

In vitro and in vivo evidence for orphan nuclear receptor RORalpha function in bone metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

T0901317 is a dual LXR/FXR agonist

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003750

27 October 2018

Identifiers

DOI

10.1021/CB100223D

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11 February 2020

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11 February 2020

1 reference