Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics (Q34415921)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12444251%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

title

Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics (English)

1 reference

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15 December 2019

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2

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15 December 2019

Stefan Pöhlmann

7

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15 December 2019

10

Robert Blumenthal

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15 December 2019

12

Robert W Doms

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15 December 2019

author name string

Jacqueline D Reeves

1

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15 December 2019

Navid Ahmad

3

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15 December 2019

John L Miamidian

4

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15 December 2019

Phoebe E Harvey

5

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15 December 2019

Matthew Sharron

6

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15 December 2019

Jeffrey N Sfakianos

8

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15 December 2019

Cynthia A Derdeyn

9

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15 December 2019

Eric Hunter

11

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15 December 2019

language of work or name

English

0 references

publication date

20 November 2002

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Proceedings of the National Academy of Sciences of the United States of America

15 December 2019

published in

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15 December 2019

volume

99

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15 December 2019

page(s)

16249-16254

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15 December 2019

issue

25

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Evaluation of current approaches to inhibit HIV entry.

15 December 2019

cites work

1 reference

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6 July 2018

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6 July 2018

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6 July 2018

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HIV-1 gp41 six-helix bundle formation occurs rapidly after the engagement of gp120 by CXCR4 in the HIV-1 Env-mediated fusion process

6 July 2018

1 reference

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Sensitivity of human immunodeficiency virus type 1 to fusion inhibitors targeted to the gp41 first heptad repeat involves distinct regions of gp41 and is consistently modulated by gp120 interactions with the coreceptor

6 July 2018

1 reference

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Ligand binding characteristics of CXCR4 incorporated into paramagnetic proteoliposomes

6 July 2018

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Strong in vitro synergy between the fusion inhibitor T-20 and the CXCR4 blocker AMD-3100.

6 July 2018

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HIV-1 membrane fusion: targets of opportunity

6 July 2018

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Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion

6 July 2018

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A biosensor assay for studying ligand-membrane receptor interactions: binding of antibodies and HIV-1 Env to chemokine receptors

6 July 2018

1 reference

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Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120

6 July 2018

1 reference

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Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1

6 July 2018

1 reference

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Use of a gp120 binding assay to dissect the requirements and kinetics of human immunodeficiency virus fusion events

6 July 2018

1 reference

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Analysis of the critical domain in the V3 loop of human immunodeficiency virus type 1 gp120 involved in CCR5 utilization

6 July 2018

1 reference

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Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages

6 July 2018

1 reference

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Functional dissection of CCR5 coreceptor function through the use of CD4-independent simian immunodeficiency virus strains

6 July 2018

1 reference

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Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

6 July 2018

1 reference

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A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding

6 July 2018

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Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.

6 July 2018

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Determinants of human immunodeficiency virus type 1 resistance to gp41-derived inhibitory peptides.

6 July 2018

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Increased frequency of CCR-5 delta 32 heterozygotes among long-term non-progressors with HIV-1 infection. The Australian Long-Term Non-Progressor Study Group

6 July 2018

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Cell-cell fusion assay to study role of chemokine receptors in human immunodeficiency virus type 1 entry

6 July 2018

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Core structure of gp41 from the HIV envelope glycoprotein

6 July 2018

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The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression

6 July 2018

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The CD4-independent tropism of human immunodeficiency virus type 2 involves several regions of the envelope protein and correlates with a reduced activation threshold for envelope-mediated fusion

6 July 2018

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CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.

6 July 2018

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6 July 2018

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The ectodomain of HIV-1 env subunit gp41 forms a soluble, alpha-helical, rod-like oligomer in the absence of gp120 and the N-terminal fusion peptide

6 July 2018

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6 July 2018

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Distinct modes of human immunodeficiency virus type 1 proviral latency revealed by superinfection of nonproductively infected cell lines with recombinant luciferase-encoding viruses.

6 July 2018

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6 July 2018

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The safety, plasma pharmacokinetics, and antiviral activity of subcutaneous enfuvirtide (T-20), a peptide inhibitor of gp41-mediated virus fusion, in HIV-infected adults.

6 July 2018

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The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.

27 October 2018

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Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12444251

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.252469399

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12444251%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

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1 reference

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15 December 2019

1 reference

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