The physiology of glucagon (Q34419963)

2 August 2017

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title

The physiology of glucagon (English)

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2 August 2017

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Gerald J Taborsky

1

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2 August 2017

1 November 2010

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Journal of Diabetes Science and Technology

2 August 2017

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2 August 2017

4

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2 August 2017

6

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2 August 2017

1338-1344

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Insulin reciprocally regulates glucagon secretion in humans

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Unique arrangement of alpha- and beta-cells in human islets of Langerhans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Effect of oral amino acids on counterregulatory responses and cognitive function during insulin-induced hypoglycemia in nondiabetic and type 1 diabetic people

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Parasympathetic innervation and function of endocrine pancreas requires the glial cell line-derived factor family receptor alpha2 (GFRalpha2).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Essential role of brain-derived neurotrophic factor in adult hippocampal function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Neuropeptide Y and peptide YY immunoreactivities in the pancreas of various vertebrates

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Vesicular acetylcholine transporter (VAChT) protein: a novel and unique marker for cholinergic neurons in the central and peripheral nervous systems

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Induction of intestinal epithelial proliferation by glucagon-like peptide 2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Role of cortisol in the pathogenesis of deficient counterregulation after antecedent hypoglycemia in normal humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Loss of potentiating effect of hypoglycemia on the glucagon response to hyperaminoacidemia in IDDM.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Epinephrine secretion, hypoglycemia unawareness, and diabetic autonomic neuropathy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Hypoglycemia begets hypoglycemia in IDDM.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

In vivo inhibition of glucagon secretion by paracrine beta cell activity in man.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Mechanisms of glucagon secretion during insulin-induced hypoglycemia in man. Role of the beta cell and arterial hyperinsulinemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Stimulation of Glucagon Secretion by Epinephrine in Man

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Characterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Glucagon release induced by pancreatic nerve stimulation in the dog.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Chronic hypoglycemia increases brain glucose transport.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Pancreatic noradrenergic nerves are activated by neuroglucopenia but not by hypotension or hypoxia in the dog. Evidence for stress-specific and regionally selective activation of the sympathetic nervous system

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Endocrine regulation of protein breakdown in skeletal muscle.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Pentobarbital suppresses basal and reflexive pancreatic polypeptide release in dogs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Insulin regulation of lipolysis in nondiabetic and IDDM subjects

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Role for autonomic nervous system to increase pancreatic glucagon secretion during marked insulin-induced hypoglycemia in dogs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Intra-islet insulin permits glucose to directly suppress pancreatic A cell function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Vagal, cholinergic regulation of pancreatic polypeptide secretion

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Hormonal mechanisms of recovery from insulin-induced hypoglycemia in man

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Importance of hypoglycemia-induced glucose production during isolated glucagon deficiency

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Role of Glucagon in Diabetes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Glucagon Secretion from the Perfused Pancreas of Streptozotocin-treated Rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

The role of adrenergic mechanisms in the substrate and hormonal response to insulin-induced hypoglycemia in man

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

A quantitative analysis of the sensory and sympathetic innervation of the mouse pancreas

6 July 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229681000400607

Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229681000400607

Loss of islet sympathetic nerves and impairment of glucagon secretion in the NOD mouse: relationship to invasive insulitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229681000400607

Age at onset of type 1 diabetes in parents and recurrence risk in offspring

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229681000400607

Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229681000400607

Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229681000400607

Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229681000400607

Redundant parasympathetic and sympathoadrenal mediation of increased glucagon secretion during insulin-induced hypoglycemia in conscious rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229681000400607

Autonomic mediation of glucagon secretion during insulin-induced hypoglycemia in rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229681000400607

Hypoglycemia-associated autonomic failure in advanced type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229681000400607

Regulation of alpha-cell function by the beta-cell during hypoglycemia in Wistar rats: the "switch-off" hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229681000400607

Pancreatic sympathetic nerves contribute to increased glucagon secretion during severe hypoglycemia in dogs

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Autonomic control of pancreatic polypeptide and glucagon secretion during neuroglucopenia and hypoglycemia in mice

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005043

Role of brain in counterregulation of insulin-induced hypoglycemia in dogs

27 October 2018

1 reference

12 December 2020

Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo

1 reference

12 December 2020

Activation of autonomic nerves and the adrenal medulla contributes to increased glucagon secretion during moderate insulin-induced hypoglycemia in women

1 reference

12 December 2020

Direct quantification of norepinephrine spillover and hormone output from the pancreas of the conscious dog

1 reference

12 December 2020

Rates of glucagon activation and deactivation of hepatic glucose production in conscious dogs

1 reference

12 December 2020

Cholinergic neurons and terminal fields revealed by immunohistochemistry for the vesicular acetylcholine transporter. II. The peripheral nervous system

1 reference

12 December 2020

Hyperglucagonemia in diabetic ketoacidosis. Its prevalence and significance

1 reference

12 December 2020

Pancreatic endocrine responses to stimulation of the peripheral ends of the vagus nerves in conscious calves

1 reference

12 December 2020

Abnormal Glucose Counterregulation in Insulin-dependent Diabetes Mellitus: Interaction of Anti-Insulin Antibodies and Impaired Glucagon and Epinephrine Secretion

1 reference

12 December 2020

Role of parasympathetic nervous system in glucagon response to insulin-induced hypoglycemia in normal and diabetic rats

1 reference

12 December 2020

Glycemic actions of alanine and terbutaline in IDDM

1 reference

12 December 2020

Hepatic denervation does not significantly change the response of the liver to glucagon in conscious dogs

1 reference

12 December 2020

The mechanism of vagal nerve stimulation of glucagon and insulin secretion in the dog

1 reference

12 December 2020

Hepatic glucagon clearance during insulin induced hypoglycemia

1 reference

12 December 2020

Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing

1 reference

12 December 2020

Morphologic and functional changes in sympathetic nerve relationships with pancreatic alpha-cells after destruction of beta-cells in rats

1 reference

12 December 2020

Sympathetic nerve stimulation versus pancreatic norepinephrine infusion in the dog: 1). Effects on basal release of insulin and glucagon

1 reference

12 December 2020

Correlation between minimal secretory capacity of pancreatic beta-cells and stability of diabetic control

1 reference

12 December 2020

10.1177/193229681000400607

Identifiers

DOI

1 reference

2 August 2017

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2 August 2017

1 reference

PubMed ID

21129328