Engineered antibody Fc variants with enhanced effector function (Q34424958)

2 August 2017

Engineered antibody Fc variants with enhanced effector function (English)

1 reference

2 August 2017

1 reference

Greg A Lazar

1

1 reference

2 August 2017

Wei Dang

2

1 reference

2 August 2017

Sher Karki

3

1 reference

2 August 2017

Omid Vafa

4

1 reference

2 August 2017

Judy S Peng

5

1 reference

2 August 2017

Linus Hyun

6

1 reference

2 August 2017

Cheryl Chan

7

1 reference

2 August 2017

Helen S Chung

8

1 reference

2 August 2017

Araz Eivazi

9

1 reference

2 August 2017

Sean C Yoder

10

1 reference

2 August 2017

Jost Vielmetter

11

1 reference

2 August 2017

David F Carmichael

12

1 reference

2 August 2017

Robert J Hayes

13

1 reference

2 August 2017

Bassil I Dahiyat

14

1 reference

2 August 2017

language of work or name

English

0 references

publication date

6 March 2006

1 reference

Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

1 reference

2 August 2017

103

1 reference

2 August 2017

11

1 reference

2 August 2017

4005-4010

1 reference

High concentrations of therapeutic IgG1 antibodies are needed to compensate for inhibition of antibody-dependent cellular cytotoxicity by excess endogenous immunoglobulin G.

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Efficient cross-priming of tumor antigen-specific T cells by dendritic cells sensitized with diverse anti-MICA opsonized tumor cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

From the bench to the bedside: ways to improve rituximab efficacy.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Fucose depletion from human IgG1 oligosaccharide enhances binding enthalpy and association rate between IgG1 and FcgammaRIIIa

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

The Her-2/neu gene and protein in breast cancer 2003: biomarker and target of therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Rational design and engineering of therapeutic proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

T cells from the tumor microenvironment of patients with progressive myeloma can generate strong, tumor-specific cytolytic responses to autologous, tumor-loaded dendritic cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Immune complex-mediated antigen presentation induces tumor immunity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Inducing tumor immunity through the selective engagement of activating Fcgamma receptors on dendritic cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Interaction sites on human IgG-Fc for FcgammaR: current models

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Recognition of immunoglobulins by Fcgamma receptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Antitumor monoclonal antibodies enhance cross-presentation ofcCellular antigens and the generation of myeloma-specific killer T cells by dendritic cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Molecular basis for immune complex recognition: a comparison of Fc-receptor structures

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Prediction of amino acid sequence from structure

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Fc receptors for IgG and antigen presentation on MHC class I and class II molecules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

The influence of the hinge region length in binding of human IgG to human Fcgamma receptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Fc receptors and their interactions with immunoglobulins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Protein design automation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Localization of the binding site for the human high-affinity Fc receptor on IgG.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

Mapping and comparison of the interaction sites on the Fc region of IgG responsible for triggering antibody dependent cellular cytotoxicity (ADCC) through different types of human Fc gamma receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1389705

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508123103

Rituximab-dependent cytotoxicity by natural killer cells: influence of FCGR3A polymorphism on the concentration-effect relationship.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508123103

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508123103

Competition BIAcore for measuring true affinities: large differences from values determined from binding kinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508123103

Allelic polymorphisms in the FcgammaRIIC gene can influence its function on normal human natural killer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508123103

Rituximab-mediated depletion of cynomolgus monkey B cells in vitro in different matrices: possible inhibitory effect of IgG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508123103

Determination of Association Rate Constants by an Optical Biosensor Using Initial Rate Analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508123103

Lysine 322 in the human IgG3 CH2 domain is crucial for antibody dependent complement activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508123103

A novel PCR-based method for direct Fc gamma receptor IIIa (CD16) allotyping

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16537476

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16537476

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Quantitative analysis of the effect of CD16 ligation on human NK cell proliferation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16537476

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0508123103

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference