A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock. (Q34425911)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

title

A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

0 references

1 reference

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Jason D. Christie

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Muredach P. Reilly

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

1

Nuala J Meyer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

7

Chenyi Xue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

13

Keith R Walley

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

10

John H Boyd

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

author name string

Jane F Ferguson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Rui Feng

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Fan Wang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Parth N Patel

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Mingyao Li

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Liming Qu

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

James A Russell

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

language of work or name

English

0 references

publication date

1 September 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

American Journal of Respiratory and Critical Care Medicine

11 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

volume

190

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

page(s)

656-664

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

CTCF: an architectural protein bridging genome topology and function

11 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Tissue-specific RNA-Seq in human evoked inflammation identifies blood and adipose LincRNA signatures of cardiometabolic diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Evaluating the impact of sequencing depth on transcriptome profiling in human adipose

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Race and gender variation in response to evoked inflammation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Identification of sepsis subtypes in critically ill adults using gene expression profiling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Interleukin-1 receptor antagonist gene polymorphism increases susceptibility to septic shock in children with acute lymphoblastic leukemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Landscape of transcription in human cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

An integrated encyclopedia of DNA elements in the human genome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Adipose genes down-regulated during experimental endotoxemia are also suppressed in obesity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Genome-wide associated loci influencing interleukin (IL)-10, IL-1Ra, and IL-6 levels in African Americans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

A genomic storm in critically injured humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Validation of a gene expression-based subclassification strategy for pediatric septic shock.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Genome-wide assessment of imprinted expression in human cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

The IL1RN promoter rs4251961 correlates with IL-1 receptor antagonist concentrations in human infection and is differentially regulated by GATA-1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Integrating common and rare genetic variation in diverse human populations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Genome-wide allele-specific analysis: insights into regulatory variation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Heritable individual-specific and allele-specific chromatin signatures in humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

A composite of multiple signals distinguishes causal variants in regions of positive selection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Constructing genomic maps of positive selection in humans: where do we go from here?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Human endotoxemia as a model of systemic inflammation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Vasopressin versus norepinephrine infusion in patients with septic shock.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

VISTA Enhancer Browser--a database of tissue-specific human enhancers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

The molecular signature of selection underlying human adaptations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

A network-based analysis of systemic inflammation in humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Population history and natural selection shape patterns of genetic variation in 132 genes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Genetic signatures of strong recent positive selection at the lactase gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Early goal-directed therapy in the treatment of severe sepsis and septic shock

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Biologic basis for interleukin-1 in disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Interleukin-1 receptor blockade improves survival and hemodynamic performance in Escherichia coli septic shock, but fails to alter host responses to sublethal endotoxemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214110

Nationwide trends of severe sepsis in the 21st century (2000-2007).

6 July 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201403-0586OC

Current epidemiology of septic shock: the CUB-Réa Network.

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201403-0586OC

Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201403-0586OC

Leucyl/cystinyl aminopeptidase gene variants in septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201403-0586OC

Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201403-0586OC

beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201403-0586OC

Genetic variation of the interleukin-1 family and nongenetic factors determining the interleukin-1 receptor antagonist phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201403-0586OC

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201403-0586OC

Evidence of a pharmacogenomic response to interleukin-l receptor antagonist in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201403-0586OC

Homology in systemic neutrophil response induced by human experimental endotoxemia and by trauma

21 January 2018

1 reference

12 December 2020

Dual inhibition of interleukin-1β and interleukin-18: a new treatment option for sepsis?

1 reference

12 December 2020

Interleukin-1 receptor antagonist gene polymorphism and mortality in patients with severe sepsis

1 reference

12 December 2020

Genomic polymorphism within interleukin-1 family cytokines influences the outcome of septic patients

1 reference

12 December 2020

Adipose tissue is a major source of interleukin-1 receptor antagonist: upregulation in obesity and inflammation

1 reference

12 December 2020

Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes

1 reference

12 December 2020

Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: II. IL-1 receptor antagonist inhibits lipopolysaccharide-induced cytokine synthesis by human monocytes

1 reference

12 December 2020

Serum Cytokine Levels in Human Septic Shock

1 reference

12 December 2020

Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome

1 reference

12 December 2020

Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: a randomized, open-label, placebo-controlled multicenter trial

1 reference

12 December 2020

Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group

1 reference

12 December 2020

Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism

1 reference

12 December 2020

Comparison of two polymorphisms of the interleukin-1 gene family: interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis

1 reference

12 December 2020

Haplotypes of IL1B, IL1RN, IL1R1, and IL1R2 and the risk of venous thrombosis

1 reference

12 December 2020

10.1164/RCCM.201403-0586OC

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25089931%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

PubMed publication ID

25089931

1 reference