The role of genomic imprinting in biology and disease: an expanding view (Q34426232)

2 August 2017

The role of genomic imprinting in biology and disease: an expanding view (English)

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2 August 2017

Jo Peters

1

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2 August 2017

24 June 2014

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2 August 2017

Nature Reviews Genetics

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2 August 2017

15

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2 August 2017

8

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2 August 2017

517-530

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https://scigraph.springernature.com/pub.10.1038/nrg3766

2 August 2017

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cites work

Completion of mouse embryogenesis requires both the maternal and paternal genomes

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Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis

21 January 2018

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Differential activity of maternally and paternally derived chromosome regions in mice

21 January 2018

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Genetic imprinting suggested by maternal heterodisomy in nondeletion Prader-Willi syndrome.

21 January 2018

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The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus

21 January 2018

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Parental imprinting of the mouse H19 gene

21 January 2018

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Parental imprinting of the mouse insulin-like growth factor II gene.

21 January 2018

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Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome

21 January 2018

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Epigenetics, brain evolution and behaviour

21 January 2018

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Genomic imprinting: a mammalian epigenetic discovery model

21 January 2018

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Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism

21 January 2018

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Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

21 January 2018

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A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10

21 January 2018

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Transcription is required for establishment of germline methylation marks at imprinted genes

21 January 2018

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Transcription and histone methylation changes correlate with imprint acquisition in male germ cells

21 January 2018

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Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes

21 January 2018

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Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a

21 January 2018

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The non-coding Air RNA is required for silencing autosomal imprinted genes

21 January 2018

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Uncoupling antisense-mediated silencing and DNA methylation in the imprinted Gnas cluster.

21 January 2018

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X-inactivation, imprinting, and long noncoding RNAs in health and disease

21 January 2018

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The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin

21 January 2018

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Imprinted Igf2r silencing depends on continuous Airn lncRNA expression and is not restricted to a developmental window.

21 January 2018

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Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

21 January 2018

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CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

21 January 2018

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Regulation of supply and demand for maternal nutrients in mammals by imprinted genes.

21 January 2018

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Genomic imprinting of Mash2, a mouse gene required for trophoblast development

21 January 2018

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Essential role of Mash-2 in extraembryonic development

21 January 2018

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Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality

21 January 2018

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Placental-specific IGF-II is a major modulator of placental and fetal growth.

21 January 2018

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Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations

21 January 2018

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Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes

21 January 2018

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Genomic imprinting, growth control and the allocation of nutritional resources: consequences for postnatal life

21 January 2018

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The H19 locus: role of an imprinted non-coding RNA in growth and development.

21 January 2018

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Maternal inheritance of a promoter variant in the imprinted PHLDA2 gene significantly increases birth weight

21 January 2018

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Current concepts in intrauterine growth restriction

21 January 2018

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The role of imprinted genes in humans

21 January 2018

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Paternal GNAS mutations lead to severe intrauterine growth retardation (IUGR) and provide evidence for a role of XLαs in fetal development.

21 January 2018

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Coadaptation in mother and infant regulated by a paternally expressed imprinted gene.

21 January 2018

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Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest.

21 January 2018

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The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding.

21 January 2018

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Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome.

21 January 2018

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Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome.

21 January 2018

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Gene Dosage Effects at the Imprinted Gnas Cluster

21 January 2018

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Loss of XLαs (extra-large αs) imprinting results in early postnatal hypoglycemia and lethality in a mouse model of pseudohypoparathyroidism Ib.

21 January 2018

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Targeted deletion of the Nesp55 DMR defines another Gnas imprinting control region and provides a mouse model of autosomal dominant PHP-Ib

21 January 2018

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Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.

21 January 2018

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A missense mutation in the non-neural G-protein alpha-subunit isoforms modulates susceptibility to obesity.

21 January 2018

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The role of GNAS and other imprinted genes in the development of obesity.

21 January 2018

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Brown adipose tissue: function and physiological significance

21 January 2018

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Imprinting control within the compact Gnas locus.

21 January 2018

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Severe obesity and insulin resistance due to deletion of the maternal Gsalpha allele is reversed by paternal deletion of the Gsalpha imprint control region

21 January 2018

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Paternal versus maternal transmission of a stimulatory G-protein alpha subunit knockout produces opposite effects on energy metabolism

21 January 2018

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Loss of Gnas imprinting differentially affects REM/NREM sleep and cognition in mice

21 January 2018

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Elevated blood pressure, heart rate and body temperature in mice lacking the XLαs protein of the Gnas locus is due to increased sympathetic tone

21 January 2018

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Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin

21 January 2018

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Imprinted gene dosage is critical for the transition to independent life.

21 January 2018

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Huddling: brown fat, genomic imprinting and the warm inner glow.

21 January 2018

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Gsα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsα mutations

21 January 2018

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Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation

21 January 2018

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The central melanocortin system can directly regulate serum insulin levels.

21 January 2018

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Central melanocortin receptors regulate insulin action

21 January 2018

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Necdin controls proliferation of white adipocyte progenitor cells

21 January 2018

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Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity

21 January 2018

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Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size

21 January 2018

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Recommendations for the investigation of animal models of Prader-Willi syndrome

21 January 2018

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Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndrome

21 January 2018

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Magel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in mice

21 January 2018

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SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth deficiency and hyperphagia in mice

21 January 2018

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Ras-GRF1 signaling is required for normal beta-cell development and glucose homeostasis

21 January 2018

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The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice

21 January 2018

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Postnatal changes in the expression pattern of the imprinted signalling protein XLαs underlie the changing phenotype of deficient mice

21 January 2018

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Physiological dysfunctions associated with mutations of the imprinted Gnas locus.

21 January 2018

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mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

21 January 2018

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The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

21 January 2018

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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

21 January 2018

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The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion

21 January 2018

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Metabolic programming in the immediate postnatal period

21 January 2018

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Genomic imprinting effects on brain development and function

21 January 2018

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Sleep disturbances in Ube3a maternal-deficient mice modeling Angelman syndrome.

21 January 2018

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Gene dosage effects of the imprinted delta-like homologue 1 (dlk1/pref1) in development: implications for the evolution of imprinting

21 January 2018

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Relative functions of Gαs and its extra-large variant XLαs in the endocrine system

21 January 2018

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A mouse model of albright hereditary osteodystrophy generated by targeted disruption of exon 1 of the Gnas gene

21 January 2018

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Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3.

21 January 2018

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Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism

21 January 2018

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Inbreeding, maternal care and genomic imprinting.

21 January 2018

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Rem sleep, early experience, and the development of reproductive strategies

21 January 2018

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The imprinted gene Magel2 regulates normal circadian output.

21 January 2018

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A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure

21 January 2018

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Angelman syndrome 2005: updated consensus for diagnostic criteria.

21 January 2018

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The interrelationship between sleep regulation and thermoregulation

21 January 2018

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Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

21 January 2018

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Dosage-sensitivity of imprinted genes expressed in the brain: 15q11-q13 and neuropsychiatric illness

21 January 2018

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The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.

21 January 2018

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Parent-of-origin effects in autism identified through genome-wide linkage analysis of 16,000 SNPs

21 January 2018

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Analysis of IMGSAC autism susceptibility loci: evidence for sex limited and parent of origin specific effects.

21 January 2018

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Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex.

21 January 2018

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Dominant rats are natural risk takers and display increased motivation for food reward

21 January 2018

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Brain-expressed imprinted genes and adult behaviour: the example of Nesp and Grb10.

21 January 2018

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Imprinted Nesp55 influences behavioral reactivity to novel environments

21 January 2018

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A model for genomic imprinting in the social brain: juveniles.

21 January 2018

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Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells

21 January 2018

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Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis

21 January 2018

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Parental imprinting regulates insulin-like growth factor signaling: a Rosetta Stone for understanding the biology of pluripotent stem cells, aging and cancerogenesis

21 January 2018

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Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence.

21 January 2018

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Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci.

21 January 2018

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Genomic imprinting syndromes and cancer.

21 January 2018

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Genomic imprinting and cancer: from primordial germ cells to somatic cells.

21 January 2018

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Global loss of imprinting leads to widespread tumorigenesis in adult mice

21 January 2018

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Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis

21 January 2018

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Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

21 January 2018

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Global survey of genomic imprinting by transcriptome sequencing

21 January 2018

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Critical evaluation of imprinted gene expression by RNA-Seq: a new perspective

21 January 2018

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The mammalian gene function resource: the International Knockout Mouse Consortium

21 January 2018

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The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping

21 January 2018

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Beyond knockouts: cre resources for conditional mutagenesis

21 January 2018

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Genomic imprinting and the social brain

21 January 2018

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Imprinting on chromosome 20: tissue-specific imprinting and imprinting mutations in the GNAS locus

21 January 2018

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Prader-Willi syndrome and Angelman syndrome

21 January 2018

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Truncating mutations of MAGEL2 cause Prader-Willi phenotypes and autism

21 January 2018

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A candidate model for Angelman syndrome in the mouse.

21 January 2018

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Transient neonatal diabetes mellitus type 1.

21 January 2018

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Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM

21 January 2018

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Genomic imprinting at the mammalian Dlk1-Dio3 domain

21 January 2018

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Paternal uniparental disomy 14 and related disorders: placental gene expression analyses and histological examinations.

21 January 2018

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Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene

21 January 2018

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New mutations at the imprinted Gnas cluster show gene dosage effects of Gsα in postnatal growth and implicate XLαs in bone and fat metabolism but not in suckling

21 January 2018

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Loss of the Prader-Willi obesity syndrome protein necdin promotes adipogenesis.

21 January 2018

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Impaired hypothalamic regulation of endocrine function and delayed counterregulatory response to hypoglycemia in Magel2-null mice.

21 January 2018

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Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation

21 January 2018

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Two ENU-induced mutations in Rasgrf1 and early mouse growth retardation.

21 January 2018

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Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life

21 January 2018

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Meg1/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1R and IR cascades.

21 January 2018

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Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation.

21 January 2018

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Type 3 deiodinase is critical for the maturation and function of the thyroid axis

21 January 2018

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Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome

21 January 2018

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Complementation studies with mouse translocations

21 January 2018

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Coadaptation and conflict, misconception and muddle, in the evolution of genomic imprinting

31 March 2020

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Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing

31 March 2020

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Re-investigation and RNA sequencing-based identification of genes with placenta-specific imprinted expression

31 March 2020

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A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene

31 March 2020

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Two imprinted gene mutations: three phenotypes

31 March 2020

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Increased body fat in mice with a targeted mutation of the paternally expressed imprinted gene Peg3.

31 March 2020

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Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1).

31 March 2020

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A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas

31 March 2020

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Imprinting of distal mouse chromosome 2 is associated with phenotypic anomalies in utero

31 March 2020

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Deletion of a nuclease-sensitive region between the Igf2 and H19 genes leads to Igf2 misregulation and increased adiposity

31 March 2020

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Time of initiation and site of action of the mouse chromosome 11 imprinting effects

31 March 2020

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Genetic abnormalities in Prader-Willi syndrome and lessons from mouse models.

31 March 2020

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12 December 2020

WAMIDEX: a web atlas of murine genomic imprinting and differential expression

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12 December 2020

Genomic imprinting in mammalian development: a parental tug-of-war

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12 December 2020

Genomic imprinting, sex-biased dispersal, and social behavior.

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12 December 2020

An Analysis of Translocations in the Mouse

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12 December 2020

Mice Lacking Ras-GRF1 Show Contextual Fear Conditioning but not Spatial Memory Impairments: Convergent Evidence from Two Independently Generated Mouse Mutant Lines

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12 December 2020

The spectrum of Silver-Russell syndrome: a clinical and molecular genetic study and new diagnostic criteria

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12 December 2020

Identifiers

DOI

10.1038/NRG3766

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PubMed ID

24958438

Dimensions Publication ID

2 August 2017

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1 reference

PubMed ID

24958438