Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes (Q34443912)

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21 February 2020

title

Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes (English)

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21 February 2020

2

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21 February 2020

Fleur M Ferguson

10

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4

Cynthia Tallant

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21 February 2020

author name string

Matthias G J Baud

1

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21 February 2020

Teresa Cardote

3

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21 February 2020

Annica Pschibul

5

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21 February 2020

Kwok-Ho Chan

6

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21 February 2020

Michael Zengerle

7

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21 February 2020

Jordi R Garcia

8

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Terence T-L Kwan

9

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21 February 2020

Alessio Ciulli

11

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21 February 2020

language of work or name

English

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publication date

16 October 2014

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21 February 2020

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21 February 2020

volume

346

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issue

6209

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21 February 2020

page(s)

638-641

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Targeting bromodomains: epigenetic readers of lysine acetylation

21 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458378

Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle

6 July 2018

1 reference

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ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

6 July 2018

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RNA-guided human genome engineering via Cas9

6 July 2018

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Multiplex genome engineering using CRISPR/Cas systems

6 July 2018

1 reference

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BET domain co-regulators in obesity, inflammation and cancer

6 July 2018

1 reference

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Place your BETs: the therapeutic potential of bromodomains

6 July 2018

1 reference

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

6 July 2018

1 reference

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

6 July 2018

1 reference

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

6 July 2018

1 reference

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

6 July 2018

1 reference

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Discovery and characterization of small molecule inhibitors of the BET family bromodomains

6 July 2018

1 reference

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Suppression of inflammation by a synthetic histone mimic

6 July 2018

1 reference

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Selective inhibition of BET bromodomains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458378

A chemical switch for inhibitor-sensitive alleles of any protein kinase

6 July 2018

1 reference

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Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

6 July 2018

1 reference

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Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery

6 July 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249830

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

21 January 2018

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Mobility measurement by analysis of fluorescence photobleaching recovery kinetics

21 January 2018

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Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

21 January 2018

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Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening

21 January 2018

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Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

21 January 2018

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Solving structures of protein complexes by molecular replacement with Phaser

21 January 2018

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Coot: model-building tools for molecular graphics

21 January 2018

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REFMAC5 for the refinement of macromolecular crystal structures

21 January 2018

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The CCP4 suite: programs for protein crystallography

21 January 2018

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Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

21 January 2018

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Small-molecule inhibition of BRDT for male contraception

21 January 2018

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The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

21 January 2018

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21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1249830

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25323695%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

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21 February 2020

PubMed publication ID

25323695

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25323695%20AND%20SRC:MED&resulttype=core&format=json