Immunoglobulin light chain amyloidosis: 2014 update on diagnosis, prognosis, and treatment (Q34448455)

2 August 2017

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title

Immunoglobulin light chain amyloidosis: 2014 update on diagnosis, prognosis, and treatment (English)

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2 August 2017

1

Morie A Gertz

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2 August 2017

1 December 2014

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American Journal of Hematology

2 August 2017

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2 August 2017

89

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2 August 2017

12

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2 August 2017

1132-1140

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CD32B is highly expressed on clonal plasma cells from patients with systemic light-chain amyloidosis and provides a target for monoclonal antibody-based therapy

2 August 2017

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Currents concepts on the immunopathology of amyloidosis

21 January 2018

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Increased serum free light chains precede the presentation of immunoglobulin light chain amyloidosis

21 January 2018

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Incidence and survival in non-hereditary amyloidosis in Sweden

21 January 2018

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Systemic amyloidosis in England: an epidemiological study

21 January 2018

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End-stage renal failure due to amyloidosis: outcomes in 490 ANZDATA registry cases.

21 January 2018

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Pitfalls in the diagnosis of primary amyloidosis

21 January 2018

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Molecular imaging of amyloidosis: will the heart be the next target after the brain?

21 January 2018

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Systemic amyloidosis: a challenge for the rheumatologist

21 January 2018

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Renal outcome and monoclonal immunoglobulin deposition disease in 289 old patients with blood cell dyscrasias: a single center experience

21 January 2018

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Practice parameter: the evaluation of distal symmetric polyneuropathy: the role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, the American Association of Neuromuscular an

21 January 2018

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Cardiac amyloidosis in a patient with multiple myeloma: a case report and review of literature.

21 January 2018

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Echocardiographic evaluation of cardiac amyloid

21 January 2018

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Asymptomatic immunoglobulin light chain amyloidosis (AL) at the time of diagnostic bone marrow biopsy in newly diagnosed patients with multiple myeloma and smoldering myeloma. A series of 144 cases and a review of the literature

21 January 2018

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Serum free light chain analysis may miss monoclonal light chains that urine immunofixation electrophoreses would detect.

21 January 2018

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International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders

21 January 2018

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Prevalence of monoclonal gammopathy of undetermined significance

21 January 2018

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Review of 1027 patients with newly diagnosed multiple myeloma

21 January 2018

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Prevalence and origin of amyloid in kidney biopsies.

21 January 2018

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Amyloid in endomyocardial biopsies.

21 January 2018

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Amyloid in bone marrow smears of patients affected by multiple myeloma

21 January 2018

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Amyloid load in fat tissue reflects disease severity and predicts survival in amyloidosis

21 January 2018

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Laryngeal amyloidosis causing hoarseness and airway obstruction

21 January 2018

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Nodular senile pulmonary amyloidosis: a unique case confirmed by immunohistochemistry, mass spectrometry, and genetic study

21 January 2018

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The spectrum of localized amyloidosis: a case series of 20 patients and review of the literature

21 January 2018

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Seeking confidence in the diagnosis of systemic AL (Ig light-chain) amyloidosis: patients can have both monoclonal gammopathies and hereditary amyloid proteins.

21 January 2018

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Glycosaminoglycans are part of amyloid fibrils: ultrastructural evidence in avian AA amyloid stained with cuprolinic blue and labeled with immunogold.

21 January 2018

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Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens

21 January 2018

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Mass spectrometric-based proteomic analysis of amyloid neuropathy type in nerve tissue.

21 January 2018

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Reliable typing of systemic amyloidoses through proteomic analysis of subcutaneous adipose tissue.

21 January 2018

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Mass spectrometry-based proteomic diagnosis of renal immunoglobulin heavy chain amyloidosis

21 January 2018

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Relationship between monoclonal gammopathy and cardiac amyloid type.

21 January 2018

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Renal amyloidosis: origin and clinicopathologic correlations of 474 recent cases.

21 January 2018

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Cardiac amyloidosis: approaches to diagnosis and management

21 January 2018

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Prognostic significance of strain Doppler imaging in light-chain amyloidosis.

21 January 2018

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Revised prognostic staging system for light chain amyloidosis incorporating cardiac biomarkers and serum free light chain measurements

21 January 2018

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Prognostication of survival using cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation

21 January 2018

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Troponin T level as an exclusion criterion for stem cell transplantation in light-chain amyloidosis.

21 January 2018

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The activity of lenalidomide with or without dexamethasone in patients with primary systemic amyloidosis

21 January 2018

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Serum immunoglobulin free light-chain measurement in primary amyloidosis: prognostic value and correlations with clinical features

21 January 2018

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Treatment of immunoglobulin light chain amyloidosis

21 January 2018

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Serum uric acid: novel prognostic factor in primary systemic amyloidosis

21 January 2018

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Recent improvements in survival in primary systemic amyloidosis and the importance of an early mortality risk score

21 January 2018

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New criteria for response to treatment in immunoglobulin light chain amyloidosis based on free light chain measurement and cardiac biomarkers: impact on survival outcomes

21 January 2018

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A detailed evaluation of the current renal response criteria in AL amyloidosis: is it time for a revision?

21 January 2018

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Treatment of "primary" renal amyloidosis with melphalan.

21 January 2018

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Amyloidosis: 2008 BMT Tandem Meetings (February 13-17, San Diego).

21 January 2018

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Role of high-dose chemotherapy and autologous hematopoietic cell transplantation in primary systemic amyloidosis: a systematic review

21 January 2018

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Refinement in patient selection to reduce treatment-related mortality from autologous stem cell transplantation in amyloidosis.

21 January 2018

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High-dose melphalan and peripheral blood stem cell transplantation for light-chain amyloidosis with cardiac involvement

21 January 2018

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Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem-cell transplantation

21 January 2018

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Ten-year survival after autologous stem cell transplantation for immunoglobulin light chain amyloidosis

21 January 2018

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Trends in day 100 and 2-year survival after auto-SCT for AL amyloidosis: outcomes before and after 2006.

21 January 2018

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High-dose melphalan and stem cell transplantation for patients with AL amyloidosis: trends in treatment-related mortality over the past 17 years at a single referral center.

21 January 2018

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Transplantation for amyloidosis

21 January 2018

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A patient with persistent renal AL amyloid deposition after clinical remission by HDM/SCT therapy.

21 January 2018

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Coexistent multiple myeloma or increased bone marrow plasma cells define equally high-risk populations in patients with immunoglobulin light chain amyloidosis

21 January 2018

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Changes in serum-free light chain rather than intact monoclonal immunoglobulin levels predicts outcome following therapy in primary amyloidosis

21 January 2018

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Treatment of 100 patients with primary amyloidosis: a randomized trial of melphalan, prednisone, and colchicine versus colchicine only.

21 January 2018

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Low-dose continuous oral melphalan for the treatment of primary systemic (AL) amyloidosis.

21 January 2018

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Association of melphalan and high-dose dexamethasone is effective and well tolerated in patients with AL (primary) amyloidosis who are ineligible for stem cell transplantation.

21 January 2018

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Amyloidosis: pathogenesis and new therapeutic options.

21 January 2018

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Implantable cardioverter defibrillators in patients with cardiac amyloidosis

21 January 2018

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Cyclophosphamide-bortezomib-dexamethasone (CyBorD) produces rapid and complete hematologic response in patients with AL amyloidosis.

21 January 2018

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Poor tolerance to high doses of thalidomide in patients with primary systemic amyloidosis

21 January 2018

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Treatment of patients with advanced cardiac AL amyloidosis with oral melphalan, dexamethasone, and thalidomide

21 January 2018

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Dermatologic adverse effects of lenalidomide therapy for amyloidosis and multiple myeloma

21 January 2018

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Lenalidomide and dexamethasone in the treatment of AL amyloidosis: results of a phase 2 trial

21 January 2018

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Lenalidomide in combination with melphalan and dexamethasone in patients with newly diagnosed AL amyloidosis: a multicenter phase 1/2 dose-escalation study

21 January 2018

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Melphalan, lenalidomide and dexamethasone for the treatment of immunoglobulin light chain amyloidosis: results of a phase II trial

21 January 2018

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Lenalidomide, melphalan and dexamethasone in a population of patients with immunoglobulin light chain amyloidosis with high rates of advanced cardiac involvement

21 January 2018

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Lenalidomide, cyclophosphamide, and dexamethasone (CRd) for light-chain amyloidosis: long-term results from a phase 2 trial

21 January 2018

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A phase II trial of cyclophosphamide, lenalidomide and dexamethasone in previously treated patients with AL amyloidosis.

21 January 2018

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Kidney dysfunction during lenalidomide treatment for AL amyloidosis.

21 January 2018

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Discordance between serum cardiac biomarker and immunoglobulin-free light-chain response in patients with immunoglobulin light-chain amyloidosis treated with immune modulatory drugs

21 January 2018

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Activity of pomalidomide in patients with immunoglobulin light-chain amyloidosis

21 January 2018

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Efficacy of bortezomib in systemic AL amyloidosis with relapsed/refractory clonal disease

21 January 2018

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Bortezomib in the treatment of AL amyloidosis: targeted therapy?

21 January 2018

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Weekly and twice-weekly bortezomib in patients with systemic AL amyloidosis: results of a phase 1 dose-escalation study

21 January 2018

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Sustained improvement in cardiac function with persistent amyloid deposition in a patient with multiple myeloma-associated cardiac amyloidosis treated with bortezomib

21 January 2018

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Bortezomib and dexamethasone consolidation following risk-adapted melphalan and stem cell transplantation for patients with newly diagnosed light-chain amyloidosis

21 January 2018

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Bortezomib with or without dexamethasone in primary systemic (light chain) amyloidosis

21 January 2018

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A European collaborative study of treatment outcomes in 346 patients with cardiac stage III AL amyloidosis.

21 January 2018

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Safety and efficacy of triplet regimens in newly diagnosed light chain amyloidosis

21 January 2018

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Long-term outcomes of patients with light chain amyloidosis (AL) after renal transplantation with or without stem cell transplantation

21 January 2018

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Living donor kidney and autologous stem cell transplantation for primary systemic amyloidosis (AL) with predominant renal involvement.

21 January 2018

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High-Dose Melphalan versus Melphalan plus Dexamethasone for AL Amyloidosis

21 January 2018

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Cardiac changes in systemic amyloidosis: Visualisation by magnetic resonance imaging

21 January 2018

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Identification of Amyloidogenic Light Chains Requires the Combination of Serum-Free Light Chain Assay with Immunofixation of Serum and Urine

21 January 2018

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Treatment with oral melphalan plus dexamethasone produces long-term remissions in AL amyloidosis

21 January 2018

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A phase 1/2 study of lenalidomide with low-dose oral cyclophosphamide and low-dose dexamethasone (RdC) in AL amyloidosis

21 January 2018

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Salvage therapy with lenalidomide and dexamethasone in patients with advanced AL amyloidosis refractory to melphalan, bortezomib, and thalidomide

21 January 2018

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High-Dose Melphalan versus Melphalan plus Dexamethasone for AL Amyloidosis

21 January 2018

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Cyclophosphamide, bortezomib, and dexamethasone therapy in AL amyloidosis is associated with high clonal response rates and prolonged progression-free survival

21 January 2018

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Safety and efficacy of risk-adapted cyclophosphamide, thalidomide, and dexamethasone in systemic AL amyloidosis

21 January 2018

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Renal Transplantation in Systemic Amyloidosis-Importance of Amyloid Fibril Type and Precursor Protein Abundance

21 January 2018

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Outcome in Renal AL Amyloidosis After Chemotherapy

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/AJH.23828

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2 August 2017

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PubMed ID

25407896