Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination (Q34450229)

2 August 2017

title

Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination (English)

1 reference

Recombination activating gene 2

2 August 2017

0 references

1 reference

Recombination activating 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Gabrielle J Grundy

series ordinal

1

1 reference

2 August 2017

Wei Yang

series ordinal

2

1 reference

2 August 2017

Martin Gellert

series ordinal

3

1 reference

2 August 2017

language of work or name

English

0 references

publication date

13 December 2010

1 reference

Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

published in

1 reference

2 August 2017

volume

107

1 reference

2 August 2017

issue

52

1 reference

2 August 2017

page(s)

22487-22492

1 reference

The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.

2 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

Mechanisms controlling expression of the RAG locus during lymphocyte development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

RAG2's non-core domain contributes to the ordered regulation of V(D)J recombination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

A time- and cost-efficient system for high-level protein production in mammalian cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

The bounty of RAGs: recombination signal complexes and reaction outcomes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

In vitro processing of the 3'-overhanging DNA in the postcleavage complex involved in V(D)J joining

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

Autoubiquitylation of the V(D)J recombinase protein RAG1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

Full-length RAG-2, and Not Full-length RAG-1, Specifically Suppresses RAG-mediated Transposition but Not Hybrid Joint Formation or Disintegration

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

The C-terminal portion of RAG2 protects against transposition in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

Ordered assembly of the V(D)J synaptic complex ensures accurate recombination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

V(D)J recombination: RAG proteins, repair factors, and regulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012499

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1014958107

Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1014958107

H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1014958107

Correlation between recombinase activating gene 1 ubiquitin ligase activity and V(D)J recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1014958107

21 January 2018

Identifiers

DOI

10.1073/PNAS.1014958107

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference