Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking (Q34451366)

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English	Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking	scientific article

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scholarly article

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Europe PubMed Central

2 August 2017

Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking (English)

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Europe PubMed Central

2 August 2017

7

object named as

B S Wilson

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Europe PubMed Central

2 August 2017

6

object named as

J M Oliver

1 reference

Europe PubMed Central

2 August 2017

Janet R Pfeiffer

5

object named as

J R Pfeiffer

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Europe PubMed Central

2 August 2017

author name string

S A Barker

1

1 reference

Europe PubMed Central

2 August 2017

K K Caldwell

2

1 reference

Europe PubMed Central

2 August 2017

A Hall

3

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Europe PubMed Central

2 August 2017

A M Martinez

4

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Europe PubMed Central

2 August 2017

language of work or name

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publication date

1 September 1995

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2 August 2017

Molecular Biology of the Cell

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Europe PubMed Central

2 August 2017

6

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Europe PubMed Central

2 August 2017

1145-1158

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Europe PubMed Central

2 August 2017

9

1 reference

Europe PubMed Central

2 August 2017

Signal transduction by Fc receptors: the Fc epsilon RI case

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

1 reference

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6 July 2018

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells

1 reference

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6 July 2018

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

Effects of subunit mutation on the localization to coated pits and internalization of cross-linked IgE-receptor complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.

1 reference

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Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction

1 reference

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6 July 2018

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

1 reference

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6 July 2018

Stimulation of mitogen-activated protein kinase activity by different secretory stimuli in rat basophilic leukemia cells.

1 reference

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6 July 2018

ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells

1 reference

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A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol.

1 reference

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6 July 2018

Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling

1 reference

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6 July 2018

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits

1 reference

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6 July 2018

Phosphatidylinositol 3-kinase

1 reference

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6 July 2018

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

1 reference

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6 July 2018

Membrane ruffling and signal transduction

1 reference

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6 July 2018

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

1 reference

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Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.

1 reference

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6 July 2018

Activation of the small GTP-binding proteins rho and rac by growth factor receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange

1 reference

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6 July 2018

Roles for Ca2+ stores release and two Ca2+ influx pathways in the Fc epsilon R1-activated Ca2+ responses of RBL-2H3 mast cells

1 reference

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6 July 2018

Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line

1 reference

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6 July 2018

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1 reference

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Fluoresceinated chemotactic peptide and high-affinity antifluorescein antibody as a probe of the temporal characteristics of neutrophil stimulation

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6 July 2018

Membrane and cytoskeletal changes associated with IgE-mediated serotonin release from rat basophilic leukemia cells

1 reference

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Mass measurements of inositol(1,4,5)trisphosphate in rat cerebral cortex slices using a radioreceptor assay: effects of neurotransmitters and depolarization

1 reference

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Signal transduction and cellular response in RBL-2H3 mast cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils

1 reference

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6 July 2018

Signal transduction by receptors with tyrosine kinase activity

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Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil

1 reference

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Oncogenes and signal transduction

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T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins.

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Tyrosine kinase-dependent phosphatidylinositol turnover and functional responses in the FcεR1 signalling pathway

1 reference

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6 July 2018

Isoprenoid pathway activity is required for IgE receptor-mediated, tyrosine kinase-coupled transmembrane signaling in permeabilized RBL-2H3 rat basophilic leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

Wortmannin, a microbial product inhibitor of myosin light chain kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

IgE-induced tyrosine phosphorylation of phospholipase C-gamma 1 in rat basophilic leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

Fc epsilon R1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C gamma 1 and the receptor beta gamma 2 complex, in RBL-2H3 rat basophilic leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells

1 reference

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6 July 2018

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit

1 reference

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6 July 2018

Identification of distinct populations of PI-3 kinase activity following T-cell activation.

1 reference

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6 July 2018

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

Protein-tyrosine phosphorylation: an essential component of Fc epsilon RI signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

6 July 2018

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

27 October 2018

Distinct functions of the Fc epsilon R1 gamma and beta subunits in the control of Fc epsilon R1-mediated tyrosine kinase activation and signaling responses in RBL-2H3 mast cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301273

27 October 2018

Tyrosine phosphorylation of a mitogen-activated protein kinase-like protein occurs at a late step in exocytosis. Studies with tyrosine phosphatase inhibitors and various secretagogues in rat RBL-2H3 cells.

1 reference

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27 October 2018

Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete structure and expression in transfected cells of high affinity IgE receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of IgE-mediated histamine release by myosin light chain kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A tyrosine residue in the juxtamembrane segment of the platelet-derived growth factor beta-receptor is critical for ligand-mediated endocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

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Depletion of guanine nucleotides with mycophenolic acid suppresses IgE receptor-mediated degranulation in rat basophilic leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential activation of human basophils by anti-IgE and formyl-methionyl-leucyl-phenylalanine. Indications for protein kinase C-dependent and -independent activation pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of agonist-stimulated inositol 1,4,5-trisphosphate production and calcium signaling by the myosin light chain kinase inhibitor, wortmannin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The control of mediator release from RBL-2H3 cells: roles for Ca2+, Na+, and protein kinase C1

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine kinase-dependent assembly of actin plaques linking Fc epsilon R1 cross-linking to increased cell substrate adhesion in RBL-2H3 tumor mast cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin signalling: the role of insulin receptor substrate 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

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The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation

1 reference

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Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

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based on heuristic

inferred from PubMed ID database lookup

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

based on heuristic

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Regulation of D-3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

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based on heuristic

inferred from PubMed ID database lookup

The mechanism of the calcium signal and correlation with histamine release in 2H3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

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based on heuristic

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A GTP-dependent step in the activation mechanism of capacitative calcium influx

1 reference

https://pubmed.ncbi.nlm.nih.gov/8534912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1091/MBC.6.9.1145

1 reference

Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

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