Interleukin-5: a novel target for asthma therapy (Q34451982)

2 August 2017

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title

Interleukin-5: a novel target for asthma therapy (English)

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2 August 2017

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Blümchen K

1

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2 August 2017

Kallinich T

series ordinal

2

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2 August 2017

Hamelmann E

series ordinal

3

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2 August 2017

language of work or name

English

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publication date

1 May 2001

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Expert Opinion on Biological Therapy

2 August 2017

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2 August 2017

1

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2 August 2017

3

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2 August 2017

433-453

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Changing prevalence of asthma in Australian children

2 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

20-year trends in the prevalence of asthma and chronic airflow obstruction in an HMO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Pathology of mild, severe, and fatal asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Cytokine production by allergen (Der pI)-specific CD4+ T cell clones derived from a patient with severe atopic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Towards a comprehensive view of immunoglobulin class switching

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Eosinophilic Inflammation in Asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

The eosinophil and bronchial asthma: current understanding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a marine model of airway sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Cellular and molecular regulation of eosinophil trafficking to the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Eosinophil adhesion in allergic inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Chemokines active on eosinophils: potential roles in allergic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Mechanism of membrane damage mediated by human eosinophil cationic protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Neurotoxicity of human eosinophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Cationic proteins induce airway hyperresponsiveness dependent on charge interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA-enhancing factor and eosinophil colony-stimulating factor activities: relationship to interleukin 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

The role of helper T cell products in mouse B cell differentiation and isotype regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

IL-5 synthesis by T cells of allergic subjects is regulated at the transcriptional level

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

IL-5 and its receptor: which role do they play in the immune response?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

The activation of the JAK2/STAT5 pathway is commonly involved in signaling through the human IL-5 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Interleukin-5 enhances eosinophil adhesion to bronchial epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Cellular profiles in asthmatic airways: a comparison of induced sputum, bronchial washings, and bronchoalveolar lavage fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Allergen-induced proliferation and interleukin-5 production by bronchoalveolar lavage and blood T cells after segmental allergen challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Inhibition of p38 MAP kinase as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

The failure of STAT6-deficient mice to develop airway eosinophilia and airway hyperresponsiveness is overcome by interleukin-5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Peripheral blood CD4 but not CD8 t-lymphocytes in patients with exacerbation of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survival in the context of a Th2-type pattern: effect of glucocorticoid therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Simple understanding and optimistic strategy for coping with atopic diseases. IL-5 central hypothesis on eosinophilic inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Effect of anti-IL-5 and IL-5 on airway hyperreactivity and eosinophils in guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Anti-IL-5 monoclonal antibody inhibits allergic late phase bronchial eosinophilia in guinea pigs: a therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Autocrine interaction between IL-5 and IL-1beta mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor alpha chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Structural design and molecular evolution of a cytokine receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

SUBEPITHELIAL FIBROSIS IN THE BRONCHI OF ASTHMATICS

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

A binding site on mast cells and basophils for the anti-allergic drug cromolyn

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.433

21 January 2018

Identifiers

DOI

10.1517/14712598.1.3.433

1 reference

2 August 2017

1 reference