Oncolytic virotherapy for cancer with the adenovirus dl1520 (Onyx-015): results of phase I and II trials (Q34452020)

2 August 2017

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title

Oncolytic virotherapy for cancer with the adenovirus dl1520 (Onyx-015): results of phase I and II trials (English)

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2 August 2017

phase I clinical trial

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Kirn D

1

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PubMed ID

11727523

2 August 2017

language of work or name

English

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publication date

1 May 2001

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Expert Opinion on Biological Therapy

2 August 2017

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2 August 2017

1

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2 August 2017

3

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2 August 2017

525-538

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Replication-selective microbiological agents: fighting cancer with targeted germ warfare

2 August 2017

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Replication-selective adenoviruses as oncolytic agents

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Studies on the use of viruses in the treatment of carcinoma of the cervix

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Treatment of human cancer with mumps virus

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Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

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Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas

21 January 2018

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An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

21 January 2018

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ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

21 January 2018

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Reovirus therapy of tumors with activated Ras pathway

21 January 2018

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Poxvirus vectors: orphaned and underappreciated

21 January 2018

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Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus

21 January 2018

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Adenovirus proteins that subvert host defenses

21 January 2018

1 reference

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Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

21 January 2018

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p53 alterations in recurrent squamous cell cancer of the head and neck refractory to radiotherapy

21 January 2018

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The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

21 January 2018

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p53 mutations in human cancers

21 January 2018

1 reference

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Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).

21 January 2018

1 reference

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p53-dependent cell death/apoptosis is required for a productive adenovirus infection

21 January 2018

1 reference

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a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

21 January 2018

1 reference

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Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.525

Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.525

Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence

21 January 2018

1 reference

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A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.

21 January 2018

1 reference

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A novel three-pronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.1.3.525

Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae

21 January 2018

1 reference

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Lipid A mutant Salmonella with suppressed virulence and TNFalpha induction retain tumor-targeting in vivo.

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21 January 2018

Identifiers

DOI

10.1517/14712598.1.3.525

1 reference

2 August 2017

1 reference

PubMed ID

11727523