Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states. (Q34452605)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21051540%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states (English)

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15 January 2020

4

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15 January 2020

author name string

Arvind Shakya

1

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15 January 2020

Jinsuk Kang

2

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15 January 2020

Jeffrey Chumley

3

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15 January 2020

Dean Tantin

5

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15 January 2020

language of work or name

English

0 references

publication date

4 November 2010

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Journal of Biological Chemistry

15 January 2020

published in

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15 January 2020

volume

286

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15 January 2020

issue

1

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15 January 2020

page(s)

450-459

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An expanded Oct4 interaction network: implications for stem cell biology, development, and disease

15 January 2020

cites work

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Oct-1 is responsible for the C-33T polymorphism effect in the IL-4 promoter.

6 July 2018

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Stem cells, stress, metabolism and cancer: a drama in two Octs

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An allergy-associated polymorphism in a novel regulatory element enhances IL13 expression

6 July 2018

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6 July 2018

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POU homeodomain protein Oct-1 functions as a sensor for cyclic AMP.

6 July 2018

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Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells

6 July 2018

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A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress

6 July 2018

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The homeobox gene CDX2 is aberrantly expressed and associated with an inferior prognosis in patients with acute lymphoblastic leukemia

6 July 2018

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Lamin B1 controls oxidative stress responses via Oct-1.

6 July 2018

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G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription

6 July 2018

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Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: identification of the c-myc regulatory gene network

6 July 2018

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Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

6 July 2018

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An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

6 July 2018

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Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice

6 July 2018

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Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

6 July 2018

1 reference

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

6 July 2018

1 reference

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Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia

6 July 2018

1 reference

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The human Mi-2/NuRD complex and gene regulation

6 July 2018

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Generation of germline-competent induced pluripotent stem cells

6 July 2018

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Stability and flexibility of epigenetic gene regulation in mammalian development

6 July 2018

1 reference

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Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

An inducible enhancer required for Il12b promoter activity in an insulated chromatin environment

6 July 2018

1 reference

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Regulation of NF-kappaB-dependent gene expression by the POU domain transcription factor Oct-1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

6 July 2018

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A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory

6 July 2018

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Core transcriptional regulatory circuitry in human embryonic stem cells

6 July 2018

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Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

6 July 2018

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The role of Cdx proteins in intestinal development and cancer

6 July 2018

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B cell development and immunoglobulin transcription in Oct-1-deficient mice

6 July 2018

1 reference

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Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice.

6 July 2018

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POU/TBP cooperativity: a mechanism for enhancer action from a distance

6 July 2018

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Protein kinase C(theta) in T cell activation

6 July 2018

1 reference

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Mouse lymphoid cell line selected to have high immunoglobulin promoter activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Pou homeodomain protein OCT1 is implicated in the expression of the caudal-related homeobox gene Cdx-2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Dissociation of Oct-1 from the nuclear peripheral structure induces the cellular aging-associated collagenase gene expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNase I-hypersensitive site

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Oct-1 and CCAAT/enhancer-binding protein (C/EBP) bind to overlapping elements within the interleukin-8 promoter. The role of Oct-1 as a transcriptional repressor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

An intestine-specific homeobox gene regulates proliferation and differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

The octamer/mu E4 region of the immunoglobulin heavy-chain enhancer mediates gene repression in myeloma x T-lymphoma hybrids

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Coordinate regulation of multiple human lymphokine genes by Oct-1 and potentially novel 45 and 43 kDa polypeptides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Interleukin-2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Octamer factors exert a dual effect on the IL-2 and IL-4 promoters

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Cell type- and stage-specific expression of the CD20/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Transcriptional regulation of the IL-2 gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Octamer-binding proteins from B or HeLa cells stimulate transcription of the immunoglobulin heavy-chain promoter in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products

6 July 2018

1 reference

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Activation of early gene expression in T lymphocytes by Oct-1 and an inducible protein, OAP40.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Aberrant expression of the homeobox gene CDX2 in pediatric acute lymphoblastic leukemia.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

The epigenetic magic of histone lysine methylation

27 October 2018

1 reference

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Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Yin Yang 1, Oct1, and NFAT-4 form repeating, cyclosporin-sensitive regulatory modules within the murine CD21 intronic control region

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013004

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells

27 October 2018

1 reference

12 December 2020

Octamer proteins inhibit IL-4 gene transcription in normal human CD4 T cells

1 reference

12 December 2020

Signals from CD28 induce stable epigenetic modification of the IL-2 promoter

1 reference

12 December 2020

OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.174045

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21051540%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21051540%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

21051540

1 reference