Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombin (Q34452632)

2 August 2017

Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombin (English)

1 reference

2 August 2017

Laurent O Mosnier

1

1 reference

PubMed ID

21041299

2 August 2017

language of work or name

English

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publication date

1 November 2010

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Journal of Biological Chemistry

2 August 2017

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2 August 2017

286

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2 August 2017

1

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2 August 2017

502-510

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Increase in activated protein C mediates acute traumatic coagulopathy in mice

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock

6 July 2018

1 reference

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Non-anticoagulant heparins and inhibition of cancer

6 July 2018

1 reference

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Hypercoagulable states in cardiovascular disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

The cytoprotective protein C pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Regulation of fibrinolysis by thrombin activatable fibrinolysis inhibitor, an unstable carboxypeptidase B that unites the pathways of coagulation and fibrinolysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Platelet factor 4 modulation of the thrombomodulin-protein C system

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Structure and biological interactions of heparin and heparan sulfate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Advances in the understanding of the pathogenetic pathways of disseminated intravascular coagulation result in more insight in the clinical picture and better management strategies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Efficacy and safety of recombinant human activated protein C for severe sepsis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Activation of thrombin-activable fibrinolysis inhibitor requires epidermal growth factor-like domain 3 of thrombomodulin and is inhibited competitively by protein C.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Thrombin-mediated activation of factor XI results in a thrombin-activatable fibrinolysis inhibitor-dependent inhibition of fibrinolysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Coagulation-dependent inhibition of fibrinolysis: role of carboxypeptidase-U and the premature lysis of clots from hemophilic plasma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Randomized trial of recombinant platelet factor 4 versus protamine for the reversal of heparin anticoagulation in humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

A model of the platelet factor 4 complex with heparin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Human plasma protein C: isolation, characterization, and mechanism of activation by alpha-thrombin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

Soluble thrombomodulin partially corrects the premature lysis defect in FVIII-deficient plasma by stimulating the activation of thrombin activatable fibrinolysis inhibitor

6 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.147959

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.147959

Carboxypeptidase U (TAFIa) prevents lysis from proceeding into the propagation phase through a threshold-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.147959

The intrinsic threshold of the fibrinolytic system is modulated by basic carboxypeptidases, but the magnitude of the antifibrinolytic effect of activated thrombin-activable fibrinolysis inhibitor is masked by its instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.147959

The multiple complexes formed by the interaction of platelet factor 4 with heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.147959

Contribution of natural anticoagulant and fibrinolytic factors in modulating the clinical severity of haemophilia patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.147959

Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.147959

Peptidomimetic inhibitors for activated protein C: implications for hemophilia management

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.147959

Preparation of washed platelet suspensions from human and rodent blood

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

The defective down regulation of fibrinolysis in haemophilia A can be restored by increasing the TAFI plasma concentration.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013010

The effect of activated protein C on fibrinolysis in cell-free plasma can be attributed specifically to attenuation of prothrombin activation

27 October 2018

1 reference

12 December 2020

Platelet factor 4 stimulates thrombomodulin protein C-activating cofactor activity. A structure-function analysis

1 reference

12 December 2020

Feedback activation of factor XI by thrombin in plasma results in additional formation of thrombin that protects fibrin clots from fibrinolysis

1 reference

12 December 2020

The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent

1 reference

12 December 2020

Thrombin, thrombomodulin and TAFI in the molecular link between coagulation and fibrinolysis

1 reference

12 December 2020

Platelet factor 4 binds to glycanated forms of thrombomodulin and to protein C. A potential mechanism for enhancing generation of activated protein C

1 reference

12 December 2020

Both cellular and soluble forms of thrombomodulin inhibit fibrinolysis by potentiating the activation of thrombin-activable fibrinolysis inhibitor

1 reference

12 December 2020

Plasma TAFI levels influence the clot lysis time in healthy individuals in the presence of an intact intrinsic pathway of coagulation

1 reference

12 December 2020

Improved coagulation in bleeding disorders by Non-Anticoagulant Sulfated Polysaccharides (NASP)

1 reference

12 December 2020

Factor XI dependent and independent activation of thrombin activatable fibrinolysis inhibitor (TAFI) in plasma associated with clot formation

1 reference

12 December 2020

Elements of the primary structure of thrombomodulin required for efficient thrombin-activable fibrinolysis inhibitor activation

1 reference

12 December 2020

Regulation of fibrinolysis in plasma by TAFI and protein C is dependent on the concentration of thrombomodulin

1 reference

12 December 2020

Platelet factor 4 enhances generation of activated protein C in vitro and in vivo

1 reference

12 December 2020

Platelet release in hemophilia

1 reference

12 December 2020

Improved method for purification of human platelet factor 4 by affinity and ion-exchange chromatography

1 reference

12 December 2020

Effects of heparin and N-acetyl heparin on ischemia/reperfusion-induced alterations in myocardial function in the rabbit isolated heart

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.147959

1 reference

2 August 2017

1 reference

2 August 2017

1 reference

PubMed ID

21041299