What are super-enhancers? (Q34455951)

2 August 2017

What are super-enhancers? (English)

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2 August 2017

2

Jason D Lieb

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2 August 2017

Sebastian Pott

1

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PubMed ID

25547603

2 August 2017

language of work or name

English

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publication date

1 January 2015

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2 August 2017

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2 August 2017

47

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1

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8-12

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https://scigraph.springernature.com/pub.10.1038/ng.3167

2 August 2017

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cites work

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ChIP-seq accurately predicts tissue-specific activity of enhancers

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Mapping and analysis of chromatin state dynamics in nine human cell types

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A unique chromatin signature uncovers early developmental enhancers in humans

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Histone H3K27ac separates active from poised enhancers and predicts developmental state

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Genome-wide chromatin state transitions associated with developmental and environmental cues

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Rapid and pervasive changes in genome-wide enhancer usage during mammalian development

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Master transcription factors and mediator establish super-enhancers at key cell identity genes

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Super-enhancers in the control of cell identity and disease

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Selective inhibition of tumor oncogenes by disruption of super-enhancers

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Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

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Mediator and cohesin connect gene expression and chromatin architecture

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Transcription factor cooperativity in early adipogenic hotspots and super-enhancers.

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Epigenomic enhancer profiling defines a signature of colon cancer

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Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.

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The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

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The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

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Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus

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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

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Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

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Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

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Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma.

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Translocations at 8q24 juxtapose MYC with genes that harbor superenhancers resulting in overexpression and poor prognosis in myeloma patients

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A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia

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Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus.

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Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells

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Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

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Chromatin marks identify critical cell types for fine mapping complex trait variants

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Epigenomic analysis of multilineage differentiation of human embryonic stem cells

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Locus control regions

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Position-independent, high-level expression of the human beta-globin gene in transgenic mice

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A map of open chromatin in human pancreatic islets

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Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity

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Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits

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Shadow enhancers foster robustness of Drosophila gastrulation

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7 January 2021

Phenotypic robustness conferred by apparently redundant transcriptional enhancers

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7 January 2021

Animal transcription networks as highly connected, quantitative continua

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7 January 2021

DNA regions bound at low occupancy by transcription factors do not drive patterned reporter gene expression in Drosophila

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7 January 2021

A transcription factor collective defines cardiac cell fate and reflects lineage history

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A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives.

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A gene complex controlling segmentation in Drosophila

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7 January 2021

A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

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Modulating Hox gene functions during animal body patterning

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7 January 2021

Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues.

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7 January 2021

Widespread misinterpretable ChIP-seq bias in yeast

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7 January 2021

Highly expressed loci are vulnerable to misleading ChIP localization of multiple unrelated proteins

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7 January 2021

Where does mediator bind in vivo?

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7 January 2021

Genome-scale CRISPR-Cas9 knockout screening in human cells

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7 January 2021

Identifiers

DOI

10.1038/NG.3167

1 reference

PubMed ID

25547603

Dimensions Publication ID

2 August 2017

0 references

1 reference

PubMed ID

25547603