Cytokines, signal transduction, and inflammatory demyelination: review and hypothesis (Q34458130)

2 August 2017

1 reference

title

Cytokines, signal transduction, and inflammatory demyelination: review and hypothesis (English)

1 reference

2 August 2017

Ledeen RW

1

1 reference

PubMed ID

9482240

2 August 2017

Chakraborty G

series ordinal

2

1 reference

2 August 2017

1 March 1998

1 reference

2 August 2017

Neurochemical Research

1 reference

2 August 2017

23

1 reference

2 August 2017

277-289

1 reference

2 August 2017

3

1 reference

https://scigraph.springernature.com/pub.10.1023/a:1022493013904

2 August 2017

0 references

cites work

Phosphate groups modifying myelin basic proteins are metabolically labile; methyl groups are stable

1 reference

12 December 2020

Vascular cell adhesion molecule-1 modulation by tumor necrosis factor in experimental allergic encephalomyelitis

1 reference

12 December 2020

Tumor necrosis factor-alpha messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity

1 reference

12 December 2020

Purification of phosphatidylinositol kinase from bovine brain myelin

1 reference

12 December 2020

Multiple sclerosis. Oligodendrocyte survival and proliferation in an active established lesion

1 reference

12 December 2020

Regulation of macrophage function by interferon-gamma. Somatic cell genetic approaches in murine macrophage cell lines to mechanisms of growth inhibition, the oxidative burst, and expression of the chronic granulomatous disease gene

1 reference

12 December 2020

Characterization and distribution of phagocytic macrophages in multiple sclerosis plaques

1 reference

12 December 2020

Identification of GTP-binding proteins in myelin and oligodendrocyte membranes.

1 reference

12 December 2020

Phosphorylation of endogenous protein of rat brain by cyclic adenosine 3',5'-monophosphate-dependent protein kinase.

1 reference

12 December 2020

Cytokine accumulations in CSF of multiple sclerosis patients: frequent detection of interleukin-1 and tumor necrosis factor but not interleukin-6.

1 reference

12 December 2020

Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors

1 reference

12 December 2020

Stimulation of phosphoinositide hydrolysis in myelin by muscarinic agonist and potassium.

1 reference

12 December 2020

TNF receptor distribution in human tissues

1 reference

12 December 2020

Tumor necrosis factor alpha (TNF alpha) and neurological diseases. Failure in detecting TNF alpha in the cerebrospinal fluid from patients with multiple sclerosis, AIDS dementia complex, and brain tumours

1 reference

12 December 2020

T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis

1 reference

12 December 2020

Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta

1 reference

12 December 2020

Direct injection of cytokines into the spinal cord causes autoimmune encephalomyelitis-like inflammation

1 reference

12 December 2020

Developmental changes of cholesterol ester hydrolases localized in myelin and microsomes of rat brain

1 reference

12 December 2020

Neutral sphingomyelinase action stimulates signal transduction of tumor necrosis factor-alpha in the synthesis of cholesteryl esters in human fibroblasts

1 reference

12 December 2020

Polyphosphoinositide biosynthesis in three subfractions of rat brain myelin

1 reference

12 December 2020

The biosynthesis of triiphosphoinositide by purified myelin of peripheral nerve

1 reference

12 December 2020

Oligodendrocytes in the early course of multiple sclerosis.

1 reference

12 December 2020

Myelination in rat brain: method of myelin isolation.

1 reference

12 December 2020

Ceramide: a novel second messenger

1 reference

12 December 2020

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1 reference

12 December 2020

Differential modulation of astrocyte cytokine gene expression by TGF-beta

1 reference

12 December 2020

T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions

1 reference

12 December 2020

Tumor necrosis factor induces genes involved in inflammation, cellular and tissue repair, and metabolism in murine fibroblasts

1 reference

12 December 2020

Identification and characterization of receptors for tumor necrosis factor-alpha in the brain

1 reference

12 December 2020

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein

1 reference

12 December 2020

Myelin contains neutral sphingomyelinase activity that is stimulated by tumor necrosis factor-alpha.

1 reference

12 December 2020

Muscarinic receptor binding and muscarinic receptor-mediated inhibition of adenylate cyclase in rat brain myelin

1 reference

12 December 2020

Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system

1 reference

12 December 2020

Effect of anti-interferon-gamma and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse.

1 reference

12 December 2020

Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course

1 reference

12 December 2020

Chemokine expression in murine experimental allergic encephalomyelitis

1 reference

12 December 2020

Interferon-gamma confers resistance to experimental allergic encephalomyelitis.

1 reference

12 December 2020

Differential regulation of astrocyte TNF-alpha expression by the cytokines TGF-beta, IL-6 and IL-10

1 reference

12 December 2020

Augmentation of immune-mediated demyelination by lipid haptens

1 reference

12 December 2020

Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. 3. Analysis of mechanism

1 reference

12 December 2020

Molecular profile of reactive astrocytes--implications for their role in neurologic disease

1 reference

12 December 2020

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery

1 reference

12 December 2020

Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-beta

1 reference

12 December 2020

Induction and regulation of interleukin-6 gene expression in rat astrocytes

1 reference

12 December 2020

Demyelination in vitro. Absorption studies demonstrate that galactocerebroside is a major target.

1 reference

12 December 2020

Hypothesis: a role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis

1 reference

12 December 2020

Are current immunological concepts of multiple sclerosis reflected by the immunopathology of its lesions?

1 reference

12 December 2020

Tumor necrosis factor alpha induces adhesion molecule expression on human fetal astrocytes

1 reference

12 December 2020

Interferon gamma, interleukin 4 and transforming growth factor beta in experimental autoimmune encephalomyelitis in Lewis rats: dynamics of cellular mRNA expression in the central nervous system and lymphoid cells

1 reference

12 December 2020

Cytokines in inflammatory brain lesions: helpful and harmful

1 reference

12 December 2020

Interferon-beta 1b treatment decreases tumor necrosis factor-alpha and increases interleukin-6 production in multiple sclerosis

1 reference

12 December 2020

Polyphosphoinositide mono- an diphosphoesterases of three subfractions of rat brain myelin

1 reference

12 December 2020

Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group

1 reference

12 December 2020

Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis

1 reference

12 December 2020

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma

1 reference

12 December 2020

Deposition of lipids in the developing central and peripheral nervous systems of the chicken

1 reference

12 December 2020

Widespread and selective induction of major histocompatibility complex-determined antigens in vivo by gamma interferon

1 reference

12 December 2020

Cholesterol ester metabolism in rat brain. A cholesterol ester hydrolase specifically localized in the myelin sheath.

1 reference

12 December 2020

Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor

1 reference

12 December 2020

Reversible inhibitory effects of interferon-gamma and tumour necrosis factor-alpha on oligodendroglial lineage cell proliferation and differentiation in vitro

1 reference

12 December 2020

In vitro and in vivo phosphorylation of myelin basic protein by exogenous and endogenous adenosine 3':5'-monophosphate-dependent protein kinases in brain.

1 reference

12 December 2020

Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system

1 reference

12 December 2020

The lipid composition of purified bovine brain myelin

1 reference

12 December 2020

A novel magnesium-independent neutral sphingomyelinase associated with rat central nervous system meylin

1 reference

12 December 2020

Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma in astrocytes

1 reference

12 December 2020

Serum cytokine levels in chronic progressive multiple sclerosis: interleukin-2 levels parallel tumor necrosis factor-alpha levels

1 reference

12 December 2020

Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice

1 reference

12 December 2020

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis

1 reference

12 December 2020

Tumor necrosis factor, other cytokines and disease

1 reference

12 December 2020

Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group

1 reference

12 December 2020

T cell immunity and interferon-γ secretion during experimental allergic encephalomyelitis in Lewis rats

1 reference

12 December 2020

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1 reference

12 December 2020

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1 reference

12 December 2020

Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions

1 reference

12 December 2020

Effects of Interleukin-1 and Tumor Necrosis Factor-α on Astrocytes, Microglia, Oligodendrocytes, and Glial Precursors in vitro

1 reference

12 December 2020

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha

1 reference

12 December 2020

Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerve

1 reference

12 December 2020

Phosphorylation of selected serine and threonine residues in myelin basic protein by endogenous and exogenous protein kinases

1 reference

12 December 2020

Myelin-induced experimental allergic encephalomyelitis in Lewis rats: tumor necrosis factor alpha levels in serum and cerebrospinal fluid immunohistochemical expression in glial cells and macrophages of optic nerve and spinal cord

1 reference

12 December 2020

Tumor necrosis factor and interleukin-1 in the CSF and sera of patients with multiple sclerosis

1 reference

12 December 2020

Tumor necrosis factor alpha in autoimmunity: pretty girl or old witch?

1 reference

12 December 2020

Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain

1 reference

12 December 2020

Augmented expression of tumour necrosis factor-alpha and lymphotoxin in mononuclear cells in multiple sclerosis and optic neuritis.

1 reference

12 December 2020

Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis

1 reference

12 December 2020

Tumor necrosis factor identified in multiple sclerosis brain

1 reference

12 December 2020

Ethanolamine plasmalogen & cholesterol ester metabolism in experimental allergic encephalomyelitis.

1 reference

12 December 2020

Cytokine production by cells in cerebrospinal fluid during experimental allergic encephalomyelitis in SJL/J mice.

1 reference

12 December 2020

Immunologic mechanisms and therapy in multiple sclerosis

1 reference

12 December 2020

Increased transforming growth factor-beta, interleukin-4, and interferon-gamma in multiple sclerosis

1 reference

12 December 2020

ICAM-1-independent lymphocyte transmigration across high endothelium : Differential up-regulation by interferon γ, tumor necrosis factor-α and interleukin 1β

1 reference

12 December 2020

Differential oligodendroglial expression of the tumor necrosis factor receptors in vivo and in vitro

1 reference

12 December 2020

Inhibition of tumor necrosis factor is protective against neurologic dysfunction after active immunization of Lewis rats with myelin basic protein

1 reference

12 December 2020

Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma

1 reference

12 December 2020

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

1 reference

12 December 2020

Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains

1 reference

12 December 2020

Cytokines in the central nervous system of mice during chronic relapsing experimental allergic encephalomyelitis

1 reference

12 December 2020

Lymphokine mRNA expression in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis is associated with a host recruited CD45R hi/CD4+ population during recovery

1 reference

12 December 2020

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide

1 reference

12 December 2020

Microglia: Intrinsic immuneffector cell of the brain

1 reference

12 December 2020

Serum and CSF levels of IL-2, sIL-2R, TNF-alpha, and IL-1 beta in chronic progressive multiple sclerosis: expected lack of clinical utility

1 reference

12 December 2020

Effects of tumor necrosis factor on inward potassium current and cell morphology in cultured human oligodendrocytes

1 reference

12 December 2020

Ceramide: an intracellular signal for apoptosis

1 reference

12 December 2020

Review: cytokines and the pathogenesis of multiple sclerosis

1 reference

12 December 2020

Mechanisms of immune injury in multiple sclerosis

1 reference

12 December 2020

Sphingomyelin is synthesized at the plasma membrane of oligodendrocytes and by purified myelin membranes: a study with fluorescent- and radio-labelled ceramide analogues

1 reference

12 December 2020

Tumor necrosis factor in serum and cerebrospinal fluid of patients with multiple sclerosis

1 reference

12 December 2020

Isolation of membrane attack complex of complement from myelin membranes treated with serum complement

1 reference

12 December 2020

Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions

1 reference

12 December 2020

Characterization of guanylyl cyclase in purified myelin.

1 reference

12 December 2020

CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death.

1 reference

12 December 2020

Morphological changes in oligodendrocytes in the intact mouse optic nerve following intravitreal injection of tumour necrosis factor.

1 reference

12 December 2020

Clinical trials of interferons in multiple sclerosis. What have we learned?

1 reference

12 December 2020

Multiple sclerosis: remyelination of nascent lesions

1 reference

12 December 2020

Multiple sclerosis. Pathology of recurrent lesions.

1 reference

12 December 2020

Cytokine mRNA expression in inflammatory multiple sclerosis lesions: detection by non-radioactive in situ hybridization

1 reference

12 December 2020

The tumor necrosis factor ligand and receptor families.

1 reference

12 December 2020

Detection of G proteins in purified bovine brain myelin.

1 reference

12 December 2020

Expression of Tumor Necrosis Factor Alpha in the Developing Nervous System

1 reference

12 December 2020

Myelin movements in mature mammalian peripheral nerve fibers

1 reference

12 December 2020

Multiple sclerosis: involvement of interferons in lesion pathogenesis

1 reference

12 December 2020

Oligodendrocyte injury is an early event in lesions of multiple sclerosis.

1 reference

12 December 2020

Pathogenesis of multiple sclerosis

1 reference

12 December 2020

Cholesterol esters in developing rat brain: concentration and fatty acid composition

1 reference

12 December 2020

Guanylyl cyclase activity in rat brain myelin and white matter

1 reference

12 December 2020

A cholesterol-esterifying enzyme in rat central nervous system myelin.

1 reference

12 December 2020

Interferon and multiple sclerosis

1 reference

12 December 2020

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1 reference

12 December 2020

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1 reference

12 December 2020

Opsonization with antimyelin antibody increases the uptake and intracellular metabolism of myelin in inflammatory macrophages

1 reference

12 December 2020

The adhesion molecule and cytokine profile of multiple sclerosis lesions

1 reference

12 December 2020

The pathophysiology of myelin basic protein-induced acute experimental allergic encephalomyelitis in the Lewis rat.

1 reference

12 December 2020

Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes

1 reference

12 December 2020

Tumor necrosis factor alpha, interleukin 1 and related cytokines in brain development: normal and pathological

1 reference

12 December 2020

Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis

1 reference

12 December 2020

Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGF beta

1 reference

12 December 2020

In vivo relationship of tumor necrosis factor-alpha to blood-brain barrier damage in patients with active multiple sclerosis

1 reference

12 December 2020

Effect of anti-interferon-gamma monoclonal antibody treatment on the development of experimental allergic encephalomyelitis in resistant mouse strains.

1 reference

12 December 2020

Rapid Incorporation In Vivo of Intracerebrally Injected32Pi into Polyphosphoinositides of Three Subfractions of Rat Brain Myelin

1 reference

12 December 2020

Identification of G protein subtypes in peripheral nerve and cultured Schwann cells

1 reference

12 December 2020

Patterns of oligodendroglia pathology in multiple sclerosis

1 reference

12 December 2020

Calcium- and cyclic AMP-regulated protein kinases of bovine central-nervous-system myelin

1 reference

12 December 2020

Inflammation in EAE: role of chemokine/cytokine expression by resident and infiltrating cells

1 reference

12 December 2020

Microglia: a sensor for pathological events in the CNS

1 reference

12 December 2020

Cell surface tumor necrosis factor (TNF) accounts for monocyte- and lymphocyte-mediated killing of TNF-resistant target cells

1 reference

12 December 2020

Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations?

1 reference

12 December 2020

Survival, development, and electrical activity of central nervous system myelinated axons exposed to tumor necrosis factor in vitro.

1 reference

12 December 2020

Cellular and molecular mechanisms of autoimmune demyelination in the central nervous system

1 reference

12 December 2020

Genetic control of multiple sclerosis: increased production of lymphotoxin and tumor necrosis factor-alpha by HLA-DR2+ T cells.

1 reference

12 December 2020

TNF-alpha- and IFN-gamma-mediated signal transduction pathways: effects on glial cell gene expression and function

1 reference

12 December 2020

Superantigens: structure and relevance to human disease

1 reference

12 December 2020

Signal transduction pathways in oligodendrocytes: role of tumor necrosis factor-alpha

1 reference

12 December 2020

Phosphatidic acid and phosphoinositide turnover in myelin and its stimulation by acetylcholine

1 reference

12 December 2020

Effect of tumor necrosis factor alpha and beta on human oligodendrocytes and neurons in culture

1 reference

12 December 2020

Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury.

1 reference

12 December 2020

EAE cerebrospinal fluid augments in vitro phagocytosis and metabolism of CNS myelin by macrophages

1 reference

12 December 2020

Early myelin lesions in experimental allergic neuritis

1 reference

12 December 2020

Muscarinic cholinergic receptor-mediated phosphoinositide metabolism in peripheral nerve

1 reference

12 December 2020

Acid sphingomyelinase of human brain. Improved purification procedures and characterization

1 reference

12 December 2020

Analysis of humoral and cellular events and the role of lipid haptens during CNS demyelination

1 reference

12 December 2020

Anti?tumor necrosis factor therapy abrogates autoimmune demyelination

1 reference

12 December 2020

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions

1 reference

12 December 2020

Distribution of Schwann cell cytoplasm and plasmalemmal vesicles (caveolae) in peripheral myelin sheaths. An electron microscopic study with thin sections and freeze-fracturing

1 reference

12 December 2020

Cytotoxicity in vitro by products of specifically stimulated spleen cells: susceptibility of tumor cells and normal cells

1 reference

12 December 2020

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin

1 reference

12 December 2020

Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I

1 reference

12 December 2020

Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1022493013904

1 reference

PubMed ID

9482240

Dimensions Publication ID

2 August 2017

0 references

1 reference

PubMed ID

9482240