Organic nitrates and nitrate resistance in diabetes: the role of vascular dysfunction and oxidative stress with emphasis on antioxidant properties of pentaerithrityl tetranitrate (Q34460615)

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English	Organic nitrates and nitrate resistance in diabetes: the role of vascular dysfunction and oxidative stress with emphasis on antioxidant properties of pentaerithrityl tetranitrate	scientific article

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scholarly article

1 reference

Europe PubMed Central

2 August 2017

10 references

13 March 2019

14 March 2019

24 March 2019

17 June 2019

20 August 2019

2 October 2019

4 November 2019

7 November 2019

20 September 2020

11 October 2020

Organic nitrates and nitrate resistance in diabetes: the role of vascular dysfunction and oxidative stress with emphasis on antioxidant properties of pentaerithrityl tetranitrate (English)

1 reference

Europe PubMed Central

2 August 2017

diabetic angiopathy

10 references

13 March 2019

14 March 2019

24 March 2019

17 June 2019

20 August 2019

2 October 2019

4 November 2019

7 November 2019

20 September 2020

11 October 2020

physiological phenomenon

1 reference

20 August 2019

mechanism of action

1 reference

2 October 2019

inorganic compound

1 reference

4 November 2019

1 reference

7 November 2019

1 reference

11 October 2020

author name string

Matthias Oelze

1

1 reference

Europe PubMed Central

2 August 2017

Swenja Schuhmacher

2

1 reference

Europe PubMed Central

2 August 2017

Andreas Daiber

3

1 reference

Europe PubMed Central

2 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

27 December 2010

10 references

Europe PubMed Central

2 August 2017

13 March 2019

14 March 2019

24 March 2019

17 June 2019

20 August 2019

2 October 2019

4 November 2019

7 November 2019

11 October 2020

Experimental Diabetes Research

10 references

Europe PubMed Central

2 August 2017

13 March 2019

14 March 2019

24 March 2019

17 June 2019

20 August 2019

2 October 2019

4 November 2019

7 November 2019

11 October 2020

2010

1 reference

Europe PubMed Central

2 August 2017

213176

1 reference

Europe PubMed Central

2 August 2017

copyright license

Creative Commons Attribution 3.0 Unported

9 references

Europe PubMed Central

13 March 2019

Europe PubMed Central

14 March 2019

Europe PubMed Central

24 March 2019

Europe PubMed Central

17 June 2019

Europe PubMed Central

20 August 2019

Europe PubMed Central

2 October 2019

Europe PubMed Central

4 November 2019

Europe PubMed Central

7 November 2019

Europe PubMed Central

11 October 2020

copyright status

0 references

on focus list of Wikimedia project

0 references

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1 reference

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Pentaerythritol tetranitrate improves angiotensin II-induced vascular dysfunction via induction of heme oxygenase-1.

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Effects of pentaerythritol tetranitrate on endothelial function in coronary artery disease: results of the PENTA study

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Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin

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In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I

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Pharmacological induction of vascular extracellular superoxide dismutase expression in vivo

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6 July 2018

Non-hemodynamic effects of organic nitrates and the distinctive characteristics of pentaerithrityl tetranitrate

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Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2.

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Mitochondrial aldehyde dehydrogenase (ALDH-2)--maker of and marker for nitrate tolerance in response to nitroglycerin treatment

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Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

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AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats

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6 July 2018

First evidence for a crosstalk between mitochondrial and NADPH oxidase-derived reactive oxygen species in nitroglycerin-triggered vascular dysfunction.

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Telmisartan, ramipril, or both in patients at high risk for vascular events

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Pharmacological and clinical aspects of heme oxygenase

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Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.

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6 July 2018

New insights into bioactivation of organic nitrates, nitrate tolerance and cross-tolerance

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Possible usefulness of apocynin, an NADPH oxidase inhibitor, for nitrate tolerance: prevention of NO donor-induced endothelial cell abnormalities

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Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2-/- mice

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6 July 2018

Role of reduced lipoic acid in the redox regulation of mitochondrial aldehyde dehydrogenase (ALDH-2) activity. Implications for mitochondrial oxidative stress and nitrate tolerance

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6 July 2018

A lethal tetrad in diabetes: hyperglycemia, dyslipidemia, oxidative stress, and endothelial dysfunction

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6 July 2018

Explaining the phenomenon of nitrate tolerance

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6 July 2018

An approach to heart failure and diabetes mellitus

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Combination of isosorbide dinitrate and hydralazine in blacks with heart failure

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6 July 2018

Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy

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6 July 2018

The role of the renin angiotensin hormonal system in the metabolic syndrome and type 2 diabetes

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Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes

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Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance.

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Nitrate tolerance and the links with endothelial dysfunction and oxidative stress

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Oxidative stress and cardiovascular injury: Part II: animal and human studies

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6 July 2018

Does Nitric Oxide Mediate the Vasodilator Activity of Nitroglycerin?

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New approaches to overcome tolerance to nitrates

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Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease

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6 July 2018

Endothelial Protection by Pentaerithrityl Trinitrate: Bilirubin and Carbon Monoxide as Possible Mediators

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6 July 2018

Identification of the enzymatic mechanism of nitroglycerin bioactivation

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Pathophysiology of oxidative stress in diabetes mellitus

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The nitric oxide donor pentaerythritol tetranitrate can preserve endothelial function in established atherosclerosis

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Mechanisms underlying endothelial dysfunction in diabetes mellitus

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6 July 2018

The antioxidant defense protein ferritin is a novel and specific target for pentaerithrityl tetranitrate in endothelial cells.

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Ulster says 'NO'; explosion, resistance and tolerance. Nitric oxide and the actions of organic nitrates

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Dietary supplement with vitamin C prevents nitrate tolerance

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Protein kinase C activation and the development of diabetic complications

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Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus

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Evidence for a role of oxygen-derived free radicals and protein kinase C in nitrate tolerance

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Tolerance to nitrates and simultaneous upregulation of platelet activity prevented by enhancing antioxidant state

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Long-term angiotensin-converting enzyme inhibition with high-dose enalapril retards nitrate tolerance in large epicardial arteries and prevents rebound coronary vasoconstriction in vivo

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Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus

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The effect of hyperglycaemia on function of rat isolated mesenteric resistance artery

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Endothelium, coronary vasodilation, and organic nitrates

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6 July 2018

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance

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6 July 2018

Abnormal rheologic effects of glyceryl trinitrate in patients with non-insulin-dependent diabetes mellitus and reversal by antioxidants.

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6 July 2018

Glycosylation of Human Glomerular Basement Membrane Collagen: Increased Content of Hexose in Ketoamine Linkage and Unaltered Hydroxylysine-O-Glycosides in Patients with Diabetesd

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Sulfhydryl requirement for relaxation of vascular smooth muscle

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6 July 2018

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

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6 July 2018

Free radical activity in type 2 diabetes

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6 July 2018

Failure of captopril to prevent nitrate tolerance in congestive heart failure secondary to coronary artery disease

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6 July 2018

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes

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6 July 2018

Organic nitrate esters: clinical use and mechanisms of actions

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6 July 2018

Prevention of nitrate tolerance with angiotension converting enzyme inhibitors

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6 July 2018

Different susceptibility to the development of nitroglycerin tolerance in the arterial and venous circulation in humans. Effects of N-acetylcysteine administration.

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6 July 2018

Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus

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6 July 2018

Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease

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21 January 2018

Oxidative stress in diabetes-induced endothelial dysfunction involvement of nitric oxide and protein kinase C.

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21 January 2018

Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress, and inflammation in type 2 diabetic patients

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21 January 2018

Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice

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21 January 2018

Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen

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21 January 2018

Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite.

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21 January 2018

Xanthine oxidase is involved in free radical production in type 1 diabetes: protection by allopurinol

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21 January 2018

Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress

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21 January 2018

Effects of the superoxide dismutase-mimetic compound tempol on endothelial dysfunction in streptozotocin-induced diabetic rats

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21 January 2018

Discrepancies between nitroglycerin and NO-releasing drugs on mitochondrial oxygen consumption, vasoactivity, and the release of NO.

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21 January 2018

Ramipril treatment protects against nitrate-induced oxidative stress in eNOS-/- mice: An implication of the NADPH oxidase pathway.

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21 January 2018

Attenuation of nitrate tolerance and oxidative stress by an angiotensin II receptor blocker in patients with coronary spastic angina

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21 January 2018

Angiotensin II-receptor antagonist losartan does not prevent nitroglycerin tolerance in patients with coronary artery disease.

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21 January 2018

Roles of Superoxide, Peroxynitrite, and Protein Kinase C in the Development of Tolerance to Nitroglycerin

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21 January 2018

Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment

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21 January 2018

Comparison of the effects of pentaerythritol tetranitrate and nitroglycerin on endothelium-dependent vasorelaxation in male volunteers

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21 January 2018

Effects of the long-term administration of nicorandil on vascular endothelial function and the progression of arteriosclerosis

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21 January 2018

Differential effects of pentaerythritol tetranitrate and nitroglycerin on the development of tolerance and evidence of lipid peroxidation: a human in vivo study

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21 January 2018

The effect of high-dose pentaerythritol tetranitrate on the development of nitrate tolerance in rabbits

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21 January 2018

Monitoring white blood cell mitochondrial aldehyde dehydrogenase activity: implications for nitrate therapy in humans

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21 January 2018

Effects of nitroglycerin or pentaerithrityl tetranitrate treatment on the gene expression in rat hearts: evidence for cardiotoxic and cardioprotective effects.

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21 January 2018

Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels

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21 January 2018

Heterozygous deficiency of manganese superoxide dismutase in mice (Mn-SOD+/-): a novel approach to assess the role of oxidative stress for the development of nitrate tolerance

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21 January 2018

Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance

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21 January 2018

Oxidative stress and mitochondrial aldehyde dehydrogenase activity: a comparison of pentaerythritol tetranitrate with other organic nitrates

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21 January 2018

Oxidative stress in cyclosporine-induced hypertension: evidence of beneficial effects or tolerance development with nitrate therapy.

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21 January 2018

Lipid peroxidation is not increased in heart failure patients on modern pharmacological therapy

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21 January 2018

Lack of oxidative stress during sustained therapy with isosorbide dinitrate and pentaerythrityl tetranitrate in healthy humans: a randomized, double-blind crossover study

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https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

Evidence supporting abnormalities in nitric oxide synthase function induced by nitroglycerin in humans

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

Early vascular abnormalities and de novo nitrate tolerance in diabetes mellitus

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

NO-donors, part X [1] : investigations on the stability of pentaerythrityl tetranitrate (PETN) by HPLC-chemoluminescence-N-detection (CLND) versus UV-detection in HPLC.

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

Evidence of oxidative stress and mitochondrial dysfunctions in the testis of prepubertal diabetic rats.

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

Targeting skeletal muscle AMP-activated protein kinase to treat type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

Prevention of nitrate tolerance by long-term treatment with statins

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

Vitamin C improves endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

Absence of heme oxygenase-1 exacerbates myocardial ischemia/reperfusion injury in diabetic mice

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

The effect of an NO donor, pentaerythrityl tetranitrate, on biochemical, functional, and morphological attributes of cardiovascular system of spontaneously hypertensive rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014692

27 October 2018

Cost comparison analysis: pentaerythrithyl tetranitrate (PETN) and isosorbide dinitrate (ISDN) prescribed to diabetic patients in primary care practices in Germany.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014692

27 October 2018

Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014692

27 October 2018

Enalapril improves vascular and cardiac function in streptozotocin-diabetic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014692

27 October 2018

Usefulness of losartan, captopril, and furosemide in preventing nitrate tolerance and improving control of unstable angina pectoris

1 reference

https://api.crossref.org/works/10.1155%2F2010%2F213176

21 January 2018

Diabetes, oxidative stress, and platelet activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical, hemodynamic, and vascular evidence concerning the free radical hypothesis of nitrate tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a causal role of the renin-angiotensin system in nitrate tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term nitrate use may be deleterious in ischemic heart disease: A study using the databases from two large-scale postinfarction studies. Multicenter Myocardial Ischemia Research Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of nitrate tolerance after long-term treatment with ramipril: an endothelium-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The angiotensin II-receptor antagonist losartan does not prevent hemodynamic or vascular tolerance to nitroglycerin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitroglycerin induces late preconditioning against myocardial stunning via a PKC-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the flavoprotein inhibitor, diphenyleneiodonium sulfate, on ex vivo organic nitrate tolerance in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct comparison of the effects of nitroprusside, SIN 1, and various nitrates on platelet aggregation and soluble guanylate cyclase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary nitrate tolerance in diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitrate tolerance impairs nitric oxide-mediated vasodilation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preventive effects of angiotensin-converting enzyme inhibitors on nitrate tolerance during continuous transdermal application of nitroglycerin in patients with chronic heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized, double-blind, placebo-controlled study of carvedilol on the prevention of nitrate tolerance in patients with chronic heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapy with nitroglycerin increases coronary vasoconstriction in response to acetylcholine

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes and chronic nitrate therapy as co-determinants of somatic DNA damage in patients with coronary artery disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Once daily therapy with isosorbide-5-mononitrate causes endothelial dysfunction in humans: evidence of a free-radical-mediated mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potency and in vitro tolerance of organic nitrates: partially denitrated metabolites contribute to the tolerance-devoid activity of pentaerythrityl tetranitrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a nitrate-free interval on tolerance, vasoconstrictor sensitivity and vascular superoxide production

1 reference

https://pubmed.ncbi.nlm.nih.gov/21234399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1155/2010/213176

1 reference

Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

ResearchGate publication ID

0 references

Sitelinks

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