A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo (Q34467166)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19637155%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

title

A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo (English)

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3 February 2020

0 references

1 reference

2

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3 February 2020

Marco Mor

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6

Claudia Silva

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author name string

Jason R Clapper

1

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Alvin R King

3

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Andrea Duranti

4

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Andrea Tontini

5

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Silvano Sanchini

7

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Giorgio Tarzia

8

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Daniele Piomelli

10

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publication date

1 September 2009

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3 February 2020

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volume

4

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issue

9

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page(s)

1505-1513

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Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability

3 February 2020

cites work

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Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates

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Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.

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Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

6 July 2018

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The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

6 July 2018

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6 July 2018

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Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets

6 July 2018

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6 July 2018

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Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).

6 July 2018

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Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

6 July 2018

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Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes

6 July 2018

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Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis

6 July 2018

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Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies

6 July 2018

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6 July 2018

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Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

6 July 2018

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Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase

6 July 2018

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6 July 2018

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6 July 2018

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27 October 2018

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27 October 2018

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Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation.

27 October 2018

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27 October 2018

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Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility

27 October 2018

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27 October 2018

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27 October 2018

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12 December 2020

Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamide

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12 December 2020

Synthesis and Structure-Activity Relationships of FAAH Inhibitors: Cyclohexylcarbamic Acid Biphenyl Esters with Chemical Modulation at the Proximal Phenyl Ring

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12 December 2020

Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain

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12 December 2020

Identifiers

DOI

10.1002/CMDC.200900210

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19637155%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

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3 February 2020

PubMed publication ID

19637155

1 reference