Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury. (Q34471194)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25426072%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

title

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury (English)

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23 February 2020

5

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23 February 2020

author name string

Jeffrey L Woodhead

1

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23 February 2020

Kyunghee Yang

2

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23 February 2020

Scott Q Siler

3

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23 February 2020

Paul B Watkins

4

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23 February 2020

Hugh A Barton

6

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23 February 2020

Brett A Howell

7

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23 February 2020

publication date

7 November 2014

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Frontiers in Pharmacology

23 February 2020

published in

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23 February 2020

volume

5

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23 February 2020

page(s)

240

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Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity

23 February 2020

cites work

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Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: role of glycine conjugates

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6 July 2018

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Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method

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In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.

6 July 2018

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Hepatotoxicity by bosentan in a patient with portopulmonary hypertension: a case-report and review of the literature.

6 July 2018

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Effect of membrane cholesterol on BSEP/Bsep activity: species specificity studies for substrates and inhibitors

6 July 2018

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The enterohepatic circulation of bile acids in mammals: form and functions

6 July 2018

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Pharmacokinetics of a HER2 tyrosine kinase inhibitor CP-724,714 in patients with advanced malignant HER2 positive solid tumors: correlations with clinical characteristics and safety

6 July 2018

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Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity.

6 July 2018

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First study of the safety, tolerability, and pharmacokinetics of CP-724,714 in patients with advanced malignant solid HER2-expressing tumors

6 July 2018

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Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review

6 July 2018

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Effects of bosentan, an endothelin receptor antagonist, on bile salt export pump and multidrug resistance-associated protein 2.

6 July 2018

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Clinical pharmacology of bosentan, a dual endothelin receptor antagonist

6 July 2018

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Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity

6 July 2018

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Mechanisms of troglitazone hepatotoxicity

6 July 2018

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Optimal dosing characteristics of the angiotensin II receptor antagonist telmisartan

6 July 2018

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Bosentan, a new endothelin receptor antagonist: prediction of the systemic plasma clearance in man from combined in vivo and in vitro data

6 July 2018

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An in vitro assay to assess transporter-based cholestatic hepatotoxicity using sandwich-cultured rat hepatocytes

6 July 2018

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The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions

21 January 2018

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Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.

21 January 2018

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Contribution of mrp2 in alterations of canalicular bile formation by the endothelin antagonist bosentan

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21 January 2018

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21 January 2018

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21 January 2018

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Pharmacokinetics of orally and intravenously administered telmisartan in healthy young and elderly volunteers and in hypertensive patients

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25426072

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FPHAR.2014.00240

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25426072%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

1 reference

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23 February 2020

PubMed publication ID

25426072

1 reference

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