Model of pediatric pituitary hormone deficiency separates the endocrine and neural functions of the LHX3 transcription factor in vivo (Q34471926)

2 August 2017

title

Model of pediatric pituitary hormone deficiency separates the endocrine and neural functions of the LHX3 transcription factor in vivo (English)

1 reference

2 August 2017

Stephanie C Colvin

1

1 reference

2 August 2017

Raleigh E Malik

2

1 reference

2 August 2017

Aaron D Showalter

3

1 reference

2 August 2017

Kyle W Sloop

4

1 reference

2 August 2017

Simon J Rhodes

5

1 reference

2 August 2017

language of work or name

English

0 references

publication date

13 December 2010

1 reference

Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

published in

1 reference

2 August 2017

volume

108

1 reference

2 August 2017

issue

1

1 reference

2 August 2017

page(s)

173-178

1 reference

Genetic regulation of pituitary gland development in human and mouse

2 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

LHX3 and LHX4 transcription factors in pituitary development and disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Mechanisms underlying pituitary hypoplasia and failed cell specification in Lhx3-deficient mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Mutations in the LHX3 gene cause dysregulation of pituitary and neural target genes that reflect patient phenotypes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Molecular physiology of pituitary development: signaling and transcriptional networks

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic factor 1 to enhance gonadotrope-specific activity of the gonadotropin-releasing hormone receptor gene promoter

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

LIM-homeodomain genes in mammalian development and human disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Mouse GnRH receptor gene expression is mediated by the LHX3 homeodomain protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Adrenocorticotrope deficiency with clinical evidence for late onset in combined pituitary hormone deficiency caused by a homozygous 301-302delAG mutation of the PROP1 gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Impact of the six nucleotides downstream of the stop codon on translation termination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Adrenocorticotropin deficiency in combined pituitary hormone deficiency patients homozygous for a novel PROP1 deletion

6 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

6 July 2018

https://api.crossref.org/works/10.1073%2FPNAS.1009501108

Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

The homeodomain coordinates nuclear entry of the Lhx3 neuroendocrine transcription factor and association with the nuclear matrix

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Analysis of the human LHX3 neuroendocrine transcription factor gene and mapping to the subtelomeric region of chromosome 9

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

The LIM domain: regulation by association

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Multistep control of pituitary organogenesis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Specification of pituitary cell lineages by the LIM homeobox gene Lhx3

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Facial morphometry of Ecuadorian patients with growth hormone receptor deficiency/Laron syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017168

Differential Activation of Pituitary Hormone Genes by Human Lhx3 Isoforms with Distinct DNA Binding Properties

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1009501108

Four novel mutations of the LHX3 gene cause combined pituitary hormone deficiencies with or without limited neck rotation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1009501108

A novel mutation in the LIM homeobox 3 gene is responsible for combined pituitary hormone deficiency, hearing impairment, and vertebral malformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1009501108

A LIM-homeodomain combinatorial code for motor-neuron pathway selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1009501108

PROP1 mutations cause progressive deterioration of anterior pituitary function including adrenal insufficiency: a longitudinal analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1009501108

Ames dwarf mice exhibit somatotrope commitment but lack growth hormone-releasing factor response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1009501108

Reduced expression of the LIM-homeobox gene Lhx3 impairs growth and differentiation of Rathke's pouch and increases cell apoptosis during mouse pituitary development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1009501108

Transgenic mice expressing LHX3 transcription factor isoforms in the pituitary: effects on the gonadotrope axis and sex-specific reproductive disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1009501108

Clinical case seminar: a novel LHX3 mutation presenting as combined pituitary hormonal deficiency

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21149718

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21149718

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

New mouse dw allele: genetic location and effects on lifespan and growth hormone levels

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21149718

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1009501108

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference