Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease (Q34475645)

2 August 2017

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title

Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease (English)

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2 August 2017

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8

Marsden CD

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2 August 2017

McNaught KS

1

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2 August 2017

Carrupt PA

2

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2 August 2017

Altomare C

3

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2 August 2017

Cellamare S

4

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2 August 2017

Carotti A

5

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2 August 2017

Testa B

6

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2 August 2017

Jenner P

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2 August 2017

language of work or name

English

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publication date

1 October 1998

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2 August 2017

Biochemical Pharmacology

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2 August 2017

56

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2 August 2017

8

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2 August 2017

921-933

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New insights into the cause of Parkinson's disease

2 August 2017

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https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Xenobiotic metabolism in Parkinson's disease

7 January 2021

1 reference

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Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease

7 January 2021

1 reference

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Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia

7 January 2021

1 reference

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A selective increase in particulate superoxide dismutase activity in parkinsonian substantia nigra

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

7 January 2021

1 reference

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7 January 2021

1 reference

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Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study

7 January 2021

1 reference

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Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease.

7 January 2021

1 reference

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Neurotoxins, parkinsonism and Parkinson's disease

7 January 2021

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Drug-induced parkinsonism and other movement disorders

7 January 2021

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

7 January 2021

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Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

7 January 2021

1 reference

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) cause rapid ATP depletion in isolated hepatocytes

7 January 2021

1 reference

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Inhibition of mitochondrial alpha-ketoglutarate dehydrogenase by 1-methyl-4-phenylpyridinium ion

7 January 2021

1 reference

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Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvement

7 January 2021

1 reference

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Search for neurotoxins structurally related to 1-methyl-4-phenylpyridine (MPP+) in the pathogenesis of Parkinson's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Isoquinoline neurotoxins in the brain and Parkinson's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Biogenic amine-aldehyde condensation products: tetrahydroisoquinolines and tryptolines (beta-carbolines).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

beta-Carbolines and Tetrahydroisoquinolines: Detection and Function in Mammals

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Presence of tetrahydroisoquinoline, a parkinsonism-related compound, in foods

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Presence of tetrahydroisoquinoline and 1-methyl-tetrahydro-isoquinoline in foods: Compounds related to Parkinson's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline as novel endogenous amines in rat brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

N-methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains: in vivo microdialysis study.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

A dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigro-striatal system of the human brai

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Oxidation of N-methyl-1,2,3,4-tetrahydroisoquinoline into the N-methyl-isoquinolinium ion by monoamine oxidase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

A N-methyltransferase in human brain catalyses N-methylation of 1,2,3,4-tetrahydroisoquinoline into N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of a dopaminergic neurotoxin, N-methylisoquinolinium ion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Migration of tetrahydroisoquinoline, a possible parkinsonian neurotoxin, into monkey brain from blood as proved by gas chromatography-mass spectrometry

7 January 2021

1 reference

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1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: a novel endogenous amine in mouse brain and parkinsonian CSF.

7 January 2021

2 references

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7 January 2021

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inferred from DOI database lookup

7 January 2021

based on heuristic

Chronic administration of 1-benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine in the brain, induces parkinsonism in a primate.

1 reference

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Isoquinolines, beta-carbolines and alcohol drinking: involvement of opioid and dopaminergic mechanisms

7 January 2021

1 reference

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Inhibition of monoamine oxidase by isoquinoline derivatives. Qualitative and 3D-quantitative structure-activity relationships

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Selective inhibition of complex I of the brain electron transport system by tetrahydroisoquinoline

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Selective inhibition of complex I by N-methylisoquinolinium ion and N-methyl-1,2,3,4-tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain

7 January 2021

1 reference

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Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

7 January 2021

1 reference

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Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)

7 January 2021

1 reference

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Effect of dopamine, dimethoxyphenylethylamine, papaverine, and related compounds on mitochondrial respiration and complex I activity

7 January 2021

1 reference

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Studies on the toxicity of 1-methyl-4-phenylpyridinium ion (MPP+) against mitochondria of mouse brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Inhibition of mitochondrial respiration by analogs of 4-phenylpyridine and 1-methyl-4-phenylpyridinium cation (MPP+), the neurotoxic metabolite of MPTP

7 January 2021

1 reference

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Studies on the characterization of the inhibitory mechanism of 4'-alkylated 1-methyl-4-phenylpyridinium and phenylpyridine analogues in mitochondria and electron transport particles

7 January 2021

1 reference

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Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism

7 January 2021

1 reference

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Inhibition of mitochondrial respiration by 1,2,3,4-tetrahydroisoquinoline-like endogenous alkaloids in mouse brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Dopaminergic neurotoxicity in vivo and inhibition of mitochondrial respiration in vitro by possible endogenous pyridinium-like substances

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

N-methyl(R)salsolinol produces hydroxyl radicals: involvement to neurotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Dopamine-derived 1-methyl-6,7-dihydroxyisoquinolines as hydroxyl radical promoters and scavengers in the rat brain: in vivo and in vitro studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Changes in glutathione and cellular energy as potential mechanisms of papaverine-induced hepatotoxicity in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Studies on the uptake of N-methylisoquinolinium ion into rat striatal slices using high-performance liquid chromatography with fluorimetric detection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

1,2,3,4-Tetrahydro-2-methyl-4,6,7-isoquinolinetriol depletes catecholamines in rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Inhibition of [3H]dopamine uptake into striatal synaptosomes by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Neurotoxic effects of papaverine, tetrahydropapaverine and dimethoxyphenylethylamine on dopaminergic neurons in ventral mesencephalic-striatal co-culture.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Cytotoxicity of endogenous isoquinolines to human dopaminergic neuroblastoma SH-SY5Y cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Toxicity to PC12 cells of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Parkinsonism in monkeys produced by chronic administration of an endogenous substance of the brain, tetrahydroisoquinoline: the behavioral and biochemical changes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Tetrahydroisoquinoline lacks dopaminergic nigrostriatal neurotoxicity in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Rotational behaviour and neurochemical changes in unilateral N-methyl-norsalsolinol and 6-hydroxydopamine lesioned rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Rat brain salsolinol and blood-brain barrier

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Nigral cell loss produced by infusion of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Determination of tetrahydropapaveroline in the urine of parkinsonian patients receiving L-dopa-carbidopa (Sinemet) therapy by high-performance liquid chromatography

7 January 2021

1 reference

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Worldwide occurrence of Parkinson's disease: an updated review

7 January 2021

1 reference

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The oxidant stress hypothesis in Parkinson's disease: evidence supporting it

7 January 2021

1 reference

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Increase in salsolinol level in the cerebrospinal fluid of parkinsonian patients is related to dementia: advantage of a new high-performance liquid chromatography methodology.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

MPTP treatment combined with ethanol or acetaldehyde selectively destroys dopaminergic neurons in mouse substantia nigra

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Acetaldehyde directly enhances MPP+ neurotoxicity and delays its elimination from the striatum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Novel endogenous 1,2,3,4-tetrahydroisoquinoline derivatives: uptake by dopamine transporter and activity to induce parkinsonism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

Cytochrome P450 isozymes catalyzing 4-hydroxylation of parkinsonism-related compound 1,2,3,4-tetrahydroisoquinoline in rat liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900142-7

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-2952(98)00142-7

1 reference

2 August 2017

1 reference