Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis (Q34480454)

2 August 2017

title

Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis (English)

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2 August 2017

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Ramanuj DasGupta

8

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Cara J Gottardi

object named as

Cara J Gottardi

11

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Naftali Kaminski

object named as

Naftali Kaminski

10

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Gökhan M Mutlu

6

object named as

Gökhan M Mutlu

1 reference

2 August 2017

Anna P Lam

1

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2 August 2017

Jose D Herazo-Maya

2

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2 August 2017

Joseph A Sennello

3

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2 August 2017

Annette S Flozak

4

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2 August 2017

Susan Russell

5

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2 August 2017

G R Scott Budinger

7

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2 August 2017

John Varga

9

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2 August 2017

language of work or name

English

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publication date

1 July 2014

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American Journal of Respiratory and Critical Care Medicine

2 August 2017

published in

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2 August 2017

volume

190

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2 August 2017

issue

2

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2 August 2017

page(s)

185-195

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Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis

2 August 2017

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6 July 2018

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Rare nonconservative LRP6 mutations are associated with metabolic syndrome.

6 July 2018

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WNT/β-catenin signaling induces IL-1β expression by alveolar epithelial cells in pulmonary fibrosis

6 July 2018

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β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin

6 July 2018

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LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1.

6 July 2018

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Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

6 July 2018

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Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

6 July 2018

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Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP).

6 July 2018

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Axin pathway activity regulates in vivo pY654-β-catenin accumulation and pulmonary fibrosis

6 July 2018

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Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

6 July 2018

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β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target

6 July 2018

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Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling.

6 July 2018

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Lrp5 and Lrp6 play compensatory roles in mouse intestinal development

6 July 2018

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Genetics in pulmonary fibrosis--familial cases provide clues to the pathogenesis of idiopathic pulmonary fibrosis

6 July 2018

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Lrp5 functions in bone to regulate bone mass

6 July 2018

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An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management

6 July 2018

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Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation

6 July 2018

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An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway

6 July 2018

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Pulmonary function measures predict mortality differently in IPF versus combined pulmonary fibrosis and emphysema

6 July 2018

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Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis

6 July 2018

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Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

6 July 2018

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Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling

6 July 2018

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Wnt signaling from development to disease: insights from model systems

6 July 2018

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Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells

6 July 2018

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Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

6 July 2018

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Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion

6 July 2018

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WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis

6 July 2018

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Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

6 July 2018

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Alternative wnt signaling is initiated by distinct receptors.

6 July 2018

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Functional Wnt signaling is increased in idiopathic pulmonary fibrosis

6 July 2018

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Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs?

6 July 2018

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The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

6 July 2018

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LRP6 mutation in a family with early coronary disease and metabolic risk factors

6 July 2018

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Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

6 July 2018

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Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells

6 July 2018

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Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

6 July 2018

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Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226053

Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226053

Regulation of the effects of TGF-beta 1 by activation of latent TGF-beta 1 and differential expression of TGF-beta receptors (T beta R-I and T beta R-II) in idiopathic pulmonary fibrosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226053

Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1).

6 July 2018

1 reference

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A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis

6 July 2018

1 reference

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Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226053

Plasmin regulates the activation of cell-associated latent TGF-beta 1 secreted by rat alveolar macrophages after in vivo bleomycin injury

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226053

Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226053

The role of TGF-beta in pulmonary fibrosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226053

Silencing of STIM1 attenuates hypoxia-induced PASMCs proliferation via inhibition of the SOC/Ca2+/NFAT pathway

6 July 2018

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Relative versus absolute change in forced vital capacity in idiopathic pulmonary fibrosis

21 January 2018

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Idiopathic pulmonary fibrosis: a composite physiologic index derived from disease extent observed by computed tomography.

21 January 2018

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Time course of bleomycin-induced lung fibrosis.

21 January 2018

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TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells.

21 January 2018

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Multiple genetic loci for bone mineral density and fractures

21 January 2018

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Considerations for targeting β-catenin signaling in fibrosis.

21 January 2018

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Modulation of bleomycin-induced lung fibrosis by serotonin receptor antagonists in mice.

21 January 2018

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Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention

21 January 2018

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Regulation of type II alveolar epithelial cell proliferation by TGF-beta during bleomycin-induced lung injury in rats

21 January 2018

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12 December 2020

TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study

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Significance of elevated procollagen-III-peptide and transforming growth factor-beta levels of bronchoalveolar lavage fluids from idiopathic pulmonary fibrosis patients

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12 December 2020

Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication

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Identifiers

DOI

1 reference

release_yw3qyzfghfhr3ekul6mq2ovai4

2 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yw3qyzfghfhr3ekul6mq2ovai4

24 November 2022

mapped directly with Wikidata item

PMC publication ID

4226053

1 reference

2 August 2017

1 reference