Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor (Q34483705)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20937785%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor (English)

1 reference

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15 February 2020

3

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15 February 2020

Anthony Maxwell

4

1 reference

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15 February 2020

author name string

Subray S Hegde

1

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15 February 2020

Matthew W Vetting

2

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15 February 2020

John S Blanchard

5

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15 February 2020

language of work or name

English

0 references

publication date

11 October 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20937785%20AND%20SRC:MED&resulttype=core&format=json

Antimicrobial Agents and Chemotherapy

15 February 2020

published in

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15 February 2020

volume

55

1 reference

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15 February 2020

issue

1

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15 February 2020

page(s)

110-117

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Plasmid-mediated quinolone resistance: a multifaceted threat

15 February 2020

cites work

1 reference

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Crystallization of a pentapeptide-repeat protein by reductive cyclic pentylation of free amines with glutaraldehyde

6 July 2018

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Plasmid-mediated quinolone resistance in gram-negative bacterial species: an update

6 July 2018

1 reference

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Prevalence of plasmid-mediated quinolone resistance determinants over a 9-year period

6 July 2018

1 reference

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The pentapeptide repeat proteins MfpAMt and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complex

6 July 2018

1 reference

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Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants

6 July 2018

1 reference

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Mechanistic and Structural Analysis of Aminoglycoside N -Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant † ‡

6 July 2018

1 reference

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Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia

6 July 2018

1 reference

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6 July 2018

qnr Gene nomenclature

1 reference

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Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance

6 July 2018

1 reference

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Insights into the structural variation between pentapeptide repeat proteins--crystal structure of Rfr23 from Cyanothece 51142

6 July 2018

1 reference

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Role of a qnr-like gene in the intrinsic resistance of Enterococcus faecalis to fluoroquinolones

6 July 2018

1 reference

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New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate

6 July 2018

1 reference

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Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli

6 July 2018

1 reference

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Characterization of two potentially universal turn motifs that shape the repeated five-residues fold--crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019687

The worldwide emergence of plasmid-mediated quinolone resistance

6 July 2018

1 reference

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qnrB, another plasmid-mediated gene for quinolone resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019687

Pentapeptide repeat proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019687

Vibrionaceae as a possible source of Qnr-like quinolone resistance determinants

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019687

Origin of plasmid-mediated quinolone resistance determinant QnrA.

6 July 2018

1 reference

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Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coli topoisomerase IV

6 July 2018

1 reference

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Mechanisms of resistance to quinolones

6 July 2018

1 reference

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A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.

6 July 2018

1 reference

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Quinolone resistance in bacteria: emphasis on plasmid-mediated mechanisms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019687

Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019687

Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases

6 July 2018

1 reference

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Efflux-mediated drug resistance in bacteria

6 July 2018

1 reference

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Fluoroquinolones: action and resistance

6 July 2018

1 reference

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Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum beta-lactamase production

6 July 2018

1 reference

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Fluoroquinolone resistance among Gram-positive cocci

6 July 2018

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Mechanism of plasmid-mediated quinolone resistance

6 July 2018

1 reference

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Emerging mechanisms of fluoroquinolone resistance

6 July 2018

1 reference

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Mechanisms of action of antimicrobials: focus on fluoroquinolones

6 July 2018

1 reference

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Mechanisms of action and resistance of older and newer fluoroquinolones

6 July 2018

1 reference

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Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria

6 July 2018

1 reference

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A model for the mechanism of strand passage by DNA gyrase

6 July 2018

1 reference

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Quinolone resistance from a transferable plasmid.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019687

DNA gyrase, topoisomerase IV, and the 4-quinolones

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019687

Crystal structure of the breakage-reunion domain of DNA gyrase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019687

Topoisomerase poisons: harnessing the dark side of enzyme mechanism.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019687

Effects of quinolones on nucleoid segregation in Escherichia coli

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019687

Postantibiotic effect of CI-960, enoxacin and ciprofloxacin on Escherichia coli: effect on morphology and haemolysin activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019687

Smaqnr, a new chromosome-encoded quinolone resistance determinant in Serratia marcescens

6 July 2018

1 reference

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Qnr-like pentapeptide repeat proteins in gram-positive bacteria

27 October 2018

1 reference

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Unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental Aeromonas spp.

27 October 2018

1 reference

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Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase

27 October 2018

1 reference

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The killing effect of cryptolepine on Staphylococcus aureus

27 October 2018

1 reference

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In vivo selection of a target/efflux double mutant of Pseudomonas aeruginosa by ciprofloxacin therapy

27 October 2018

1 reference

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DNA gyrase-mediated wrapping of the DNA strand is required for the replication fork arrest by the DNA gyrase-quinolone-DNA ternary complex

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20937785

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Plasmid-mediated quinolone resistance

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20937785

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of DNA gyrase inhibitor (GyrI) in Escherichia coli

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20937785

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.01158-10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20937785%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20937785%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference