Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis. (Q34497596)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18289052%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

review article

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title

Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis (English)

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3 January 2020

2

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3 January 2020

author name string

Adam W Barb

series ordinal

1

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3 January 2020

publication date

1 February 2008

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Current Pharmaceutical Biotechnology

3 January 2020

published in

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3 January 2020

volume

9

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3 January 2020

issue

1

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3 January 2020

page(s)

9-15

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The nucleotide-binding site of Aquifex aeolicus LpxC.

3 January 2020

cites work

1 reference

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Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase

7 July 2018

1 reference

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UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism.

7 July 2018

1 reference

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Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022321

Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022321

LPS, TLR4 and infectious disease diversity.

7 July 2018

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Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis

7 July 2018

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7 July 2018

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New (and not so new) antibacterial targets - from where and when will the novel drugs come?

7 July 2018

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Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC.

7 July 2018

1 reference

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Antibacterial activities and characterization of novel inhibitors of LpxC.

7 July 2018

1 reference

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Toll-like receptors in the induction of the innate immune response

7 July 2018

1 reference

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UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme

7 July 2018

1 reference

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Antibacterial agents that inhibit lipid A biosynthesis.

7 July 2018

1 reference

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The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase

7 July 2018

1 reference

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Overproduction of outer membrane protein suppresses envA-induced hyperpermeability.

7 July 2018

1 reference

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Transcriptional organization within an Escherichia coli cell division gene cluster: direction of transcription of the cell separation gene envA

7 July 2018

1 reference

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Mutant of Escherichia coli with anomalous cell division and ability to decrease episomally and chromosomally mediated resistance to ampicillin and several other antibiotics.

7 July 2018

1 reference

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022321

Resistance in gram-negative bacteria: Enterobacteriaceae.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022321

Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022321

The C-terminal end of LpxC is required for degradation by the FtsH protease.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022321

A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022321

Deaths: leading causes for 2002.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022321

Structure of the LpxC deacetylase with a bound substrate-analog inhibitor.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022321

EXAFS studies of the zinc sites of UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC).

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022321

Antimicrobials: new solutions badly needed

27 October 2018

1 reference

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Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups

27 October 2018

1 reference

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Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site

27 October 2018

1 reference

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Regulation of UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase in Escherichia coli. The second enzymatic step of lipid a biosynthesis.

27 October 2018

1 reference

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UDP-N-acetylglucosamine acyltransferase of Escherichia coli. The first step of endotoxin biosynthesis is thermodynamically unfavorable.

27 October 2018

1 reference

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Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18289052

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18289052

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18289052

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2174/138920108783497668

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18289052%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18289052%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

PubMed publication ID

18289052

1 reference