The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons (Q34498146)

2 August 2017

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title

The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons (English)

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2 August 2017

3

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2 August 2017

1

N Craddock

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2 August 2017

M J Owen

2

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PubMed ID

16505837

2 August 2017

language of work or name

English

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publication date

1 May 2006

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2 August 2017

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2 August 2017

11

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2 August 2017

5

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2 August 2017

446-458

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https://scigraph.springernature.com/pub.10.1038/sj.mp.4001808

2 August 2017

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cites work

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Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

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Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex

21 January 2018

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Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain

21 January 2018

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Human catechol-O-methyltransferase down-regulation by estradiol

21 January 2018

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A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder and effect of Val158Met genotype

21 January 2018

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Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles.

21 January 2018

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COMT haplotypes suggest P2 promoter region relevance for schizophrenia.

21 January 2018

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Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans

21 January 2018

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Intelligence and psychosocial adjustment in velocardiofacial syndrome: a study of 37 children and adolescents with VCFS.

21 January 2018

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Bipolar spectrum disorders in patients diagnosed with velo-cardio-facial syndrome: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder?

21 January 2018

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Psychiatric disorders and behavioral problems in children with velocardiofacial syndrome: usefulness as phenotypic indicators of schizophrenia risk.

21 January 2018

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High rates of schizophrenia in adults with velo-cardio-facial syndrome.

21 January 2018

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Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia

21 January 2018

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Genomewide Linkage Scan in Schizoaffective Disorder

21 January 2018

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Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Comorbid bipolar disorder and panic disorder in families with a high prevalence of bipolar disorder

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia

21 January 2018

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Genetic and neurochemical modulation of prefrontal cognitive functions in children.

21 January 2018

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Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia.

21 January 2018

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Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

New evidence of association between COMT gene and prefrontal neurocognitive function in healthy individuals from sibling pairs discordant for psychosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome

21 January 2018

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Association study of a functional catechol-O-methyltransferase-gene polymorphism and cognitive function in healthy females

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Variation in catechol-o-methyltransferase val158 met genotype associated with schizotypy but not cognition: a population study in 543 young men.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assay

21 January 2018

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Genes, dopamine and cortical signal-to-noise ratio in schizophrenia

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Selective activation of mesocortical DA system by stress

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: a meta-analysis of case-control studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

No association between schizophrenia and polymorphisms in COMT in two large samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Catechol-O-methyltransferase gene Val108/158Met polymorphism, and susceptibility to schizophrenia: association is more significant in women

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

A highly significant association between a COMT haplotype and schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Haplotypic association spanning the 22q11.21 genes COMT and ARVCF with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

The future of association studies: gene-based analysis and replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Association studies of bipolar disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

COMT: a common susceptibility gene in bipolar disorder and schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Association analysis of the catechol-o-methyltransferase (COMT), serotonin transporter (5-HTT) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive-compulsive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder: a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

The association between panic disorder and the L/L genotype of catechol-O-methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Association between catechol-O-methyltransferase and phobic anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Association between the COMT Val158Met polymorphism and propensity to anxiety in an Australian population-based longitudinal study of adolescent health

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Catechol-O-methyl-transferase functional polymorphism and nicotine dependence: an evaluation of nonreplicated results

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Haplotype analysis of the COMT-ARVCF gene region in Israeli anorexia nervosa family trios

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Strategy for investigating interactions between measured genes and measured environments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

The effect of apomorphine on regional cerebral blood flow in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Dopamine in schizophrenia: a review and reconceptualization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

The genetics of schizophrenia and bipolar disorder: dissecting psychosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Suggestive Linkage to Chromosomal Regions 13q31 and 22q12 in Families With Psychotic Bipolar Disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Brain-derived neurotrophic factor as a potential risk locus for bipolar disorder: Evidence, limitations, and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Genome-wide association studies: theoretical and practical concerns

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Evidence for shared susceptibility in bipolar disorder and schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

The beginning of the end for the Kraepelinian dichotomy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Power and sample size calculations for case-control genetic association tests when errors are present: application to single nucleotide polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Quantifying the percent increase in minimum sample size for SNP genotyping errors in genetic model-based association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

What SNP genotyping errors are most costly for genetic association studies?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Allowing for genotyping error in analysis of unmatched case-control studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Impact of genotyping errors on type I error rate of the haplotype-sharing transmission/disequilibrium test (HS-TDT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Population structure, differential bias and genomic control in a large-scale, case-control association study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

No evidence for an association of affective disorders with high- or low-activity allele of catechol-o-methyltransferase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Catechol-O-methyltransferase Vall58Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Stressful life events, 5-HTT genotype and risk of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

Characterization of membrane-bound and soluble catechol-O-methyltransferase from human frontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

The inheritance of human erythrocyte catechol-O-methyltransferase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Characterization and implications of estrogenic down-regulation of human catechol-O-methyltransferase gene transcription.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Late‐Onset psychosis in the velo‐cardio‐facial syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol O-methyltransferase (COMT) activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Ultra-ultra rapid cycling bipolar disorder is associated with the low activity catecholamine-O-methyltransferase allele

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Thermal stability and the biochemical genetics of erythrocyte catechol-O-methyl-transferase and plasma dopamine-beta-hydroxylase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

The impact of genotyping error on haplotype reconstruction and frequency estimation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

EasyMA: a program for the meta-analysis of clinical trials

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene. Biomed European Bipolar Collaborative Group

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar affective disorder

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001808

7 January 2021

Identifiers

DOI

10.1038/SJ.MP.4001808

1 reference

2 August 2017

1 reference

PubMed ID

16505837