Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1. (Q34502151)

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15 February 2020

title

Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1 (English)

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15 February 2020

2

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15 February 2020

Anjaneyulu Kowluru

series ordinal

3

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15 February 2020

author name string

Wasanthi Subasinghe

series ordinal

1

1 reference

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15 February 2020

publication date

13 October 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20943855%20AND%20SRC:MED&resulttype=core&format=json

American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

15 February 2020

published in

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15 February 2020

volume

300

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15 February 2020

page(s)

R12-20

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15 February 2020

issue

1

1 reference

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Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic beta-cells.

15 February 2020

cites work

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Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell

7 July 2018

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Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells

7 July 2018

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Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line

7 July 2018

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Association of NAD(P)H oxidase with glucose-induced insulin secretion by pancreatic beta-cells.

7 July 2018

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Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells

7 July 2018

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NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?

7 July 2018

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Selenocystine induces apoptosis of A375 human melanoma cells by activating ROS-mediated mitochondrial pathway and p53 phosphorylation

7 July 2018

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Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells

7 July 2018

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Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line

7 July 2018

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Life and death decisions of the pancreatic beta-cell: the role of fatty acids

7 July 2018

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Expression of isoforms of NADPH oxidase components in rat pancreatic islets

7 July 2018

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Free radicals and antioxidants in normal physiological functions and human disease

7 July 2018

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Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines

7 July 2018

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Regulation of NADPH oxidases: the role of Rac proteins

7 July 2018

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Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

7 July 2018

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Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell

7 July 2018

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

7 July 2018

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7 July 2018

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7 July 2018

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Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: cleavage of the common alpha subunit during apoptosis

7 July 2018

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Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst

7 July 2018

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Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways.

7 July 2018

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Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase

21 January 2018

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Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

21 January 2018

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Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells

21 January 2018

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Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production

21 January 2018

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Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20943855

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20943855

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1152/AJPREGU.00421.2010

1 reference

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15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20943855%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference