ITAMs versus ITIMs: striking a balance during cell regulation (Q34502855)

2 August 2017

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title

ITAMs versus ITIMs: striking a balance during cell regulation (English)

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2 August 2017

Daniel D Billadeau

1

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2 August 2017

Paul J Leibson

series ordinal

2

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2 August 2017

language of work or name

English

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publication date

1 January 2002

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Journal of Clinical Investigation

2 August 2017

published in

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2 August 2017

volume

109

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2 August 2017

issue

2

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2 August 2017

page(s)

161-168

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Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail

2 August 2017

cites work

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7 July 2018

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7 July 2018

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B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta

7 July 2018

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7 July 2018

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Immune inhibitory receptors

7 July 2018

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Molecular basis of the recruitment of the SH2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 by fcgamma RIIB.

7 July 2018

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Function of CD3 epsilon-mediated signals in T cell development

7 July 2018

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The LMP2A ITAM is essential for providing B cells with development and survival signals in vivo

7 July 2018

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ITAM multiplicity and thymocyte selection: how low can you go?

7 July 2018

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7 July 2018

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The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells

7 July 2018

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Fcgamma receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease

7 July 2018

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A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice

7 July 2018

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Expression of HLA class I-specific inhibitory receptors in human cytolytic T lymphocytes: a regulated mechanism that controls T-cell activation and function.

7 July 2018

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Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling

7 July 2018

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A balance between positive and negative signals in cytotoxic lymphocytes regulates the polarization of lipid rafts during the development of cell-mediated killing

7 July 2018

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7 July 2018

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Partially phosphorylated T cell receptor zeta molecules can inhibit T cell activation

7 July 2018

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Regulation of immune responses through inhibitory receptors

7 July 2018

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SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

7 July 2018

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The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells

7 July 2018

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Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses.

7 July 2018

1 reference

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SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors

7 July 2018

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LCK-phosphorylated human killer cell-inhibitory receptors recruit and activate phosphatidylinositol 3-kinase

7 July 2018

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Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi's sarcoma-associated herpesvirus

7 July 2018

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Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation

7 July 2018

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ITAMs: immunoregulatory scaffolds that link immunoreceptors to their intracellular signaling pathways

7 July 2018

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Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

7 July 2018

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Immunoreceptor tyrosine-based inhibition motifs

7 July 2018

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The immunoglobulin (Ig)alpha and Igbeta cytoplasmic domains are independently sufficient to signal B cell maturation and activation in transgenic mice

7 July 2018

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A novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1

7 July 2018

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Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

Killer cell inhibitory receptor recognition of human leukocyte antigen (HLA) class I blocks formation of a pp36/PLC-gamma signaling complex in human natural killer (NK) cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

Antigen receptor tail clue.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

In search of the 'missing self': MHC molecules and NK cell recognition

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

Positive selection through a motif in the alphabeta T cell receptor

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

An unusual mechanism for ligand antagonism

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

Cloning and tyrosine phosphorylation of a novel invertebrate immunocyte protein containing immunoreceptor tyrosine-based activation motifs

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

New nomenclature for the Reth motif (or ARH1/TAM/ARAM/YXXL)

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150845

gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation

9 December 2018

1 reference

12 December 2020

The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors

1 reference

12 December 2020

Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

1 reference

12 December 2020

Clonotypic differences in signaling from CD94 (kp43) on NK cells lead to divergent cellular responses

1 reference

12 December 2020

Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based activation motif tyrosines in B cell antigen receptor signal transduction

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12 December 2020

CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection

1 reference

12 December 2020

Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection

1 reference

12 December 2020

Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis

1 reference

12 December 2020

Crippling of CD3-ζ ITAMs Does Not Impair T Cell Receptor Signaling

1 reference

12 December 2020

SHIP recruitment attenuates Fc gamma RIIB-induced B cell apoptosis

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12 December 2020

Cross-antagonism of a T cell clone expressing two distinct T cell receptors

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12 December 2020

Identifiers

DOI

10.1172/JCI0214843

1 reference

2 August 2017

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2 August 2017

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