The inhibition mechanism of non-phosphorylated Ser768 in the regulatory domain of cystic fibrosis transmembrane conductance regulator (Q34503233)

2 August 2017

title

The inhibition mechanism of non-phosphorylated Ser768 in the regulatory domain of cystic fibrosis transmembrane conductance regulator (English)

1 reference

2 August 2017

main subject

transmembrane protein

0 references

0 references

0 references

1

Guangyu Wang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21059651

22 August 2024

language of work or name

English

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publication date

8 November 2010

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full work available at URL

2 August 2017

http://www.jbc.org/article/S0021925820562510/pdf

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21059651

http://intl.jbc.org/cgi/content/abstract/286/3/2171

22 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21059651

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21059651/pdf/?tool=EBI

22 August 2024

file format

Portable Document Format

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21059651

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21059651/?tool=EBI

22 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21059651

https://europepmc.org/articles/PMC3023513

22 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21059651

https://europepmc.org/articles/PMC3023513?pdf=render

22 August 2024

file format

Portable Document Format

content deliverer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21059651

https://doi.org/10.1074/jbc.m110.145540

22 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21059651

Journal of Biological Chemistry

22 August 2024

published in

1 reference

2 August 2017

volume

286

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2 August 2017

issue

3

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2 August 2017

page(s)

2171-2182

1 reference

State-dependent Regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gating by a High Affinity Fe3+ Bridge between the Regulatory Domain and Cytoplasmic Loop 3

2 August 2017

cites work

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7 July 2018

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7 July 2018

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Processing mutations disrupt interactions between the nucleotide binding and transmembrane domains of P-glycoprotein and the cystic fibrosis transmembrane conductance regulator (CFTR).

7 July 2018

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Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating

7 July 2018

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Structural basis of trans-inhibition in a molybdate/tungstate ABC transporter

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Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

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CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices

7 July 2018

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G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defects

7 July 2018

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Zn2+-dependent redox switch in the intracellular T1-T1 interface of a Kv channel

7 July 2018

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Curcumin opens cystic fibrosis transmembrane conductance regulator channels by a novel mechanism that requires neither ATP binding nor dimerization of the nucleotide-binding domains

7 July 2018

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Domain interdependence in the biosynthetic assembly of CFTR.

7 July 2018

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In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer

7 July 2018

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Structure of a bacterial multidrug ABC transporter

7 July 2018

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CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains

7 July 2018

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Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.

7 July 2018

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Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

7 July 2018

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ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

7 July 2018

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A short segment of the R domain of cystic fibrosis transmembrane conductance regulator contains channel stimulatory and inhibitory activities that are separable by sequence modification

7 July 2018

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A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution

7 July 2018

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Phosphorylation by cAMP-dependent protein kinase causes a conformational change in the R domain of the cystic fibrosis transmembrane conductance regulator

7 July 2018

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

7 July 2018

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Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

7 July 2018

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Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

7 July 2018

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Architecture of the cystic fibrosis transmembrane conductance regulator protein and structural changes associated with phosphorylation and nucleotide binding.

7 July 2018

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Dibasic phosphorylation sites in the R domain of CFTR have stimulatory and inhibitory effects on channel activation

21 January 2018

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CFTR chloride channel regulation by an interdomain interaction

21 January 2018

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Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein

21 January 2018

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CFTR activation: additive effects of stimulatory and inhibitory phosphorylation sites in the R domain

21 January 2018

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Covalent modification of the regulatory domain irreversibly stimulates cystic fibrosis transmembrane conductance regulator

27 October 2018

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12 December 2020

Functional characterization of the CFTR R domain using CFTR/MDR1 hybrid and deletion constructs

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12 December 2020

Cystic fibrosis transmembrane conductance regulator Cl- channels with R domain deletions and translocations show phosphorylation-dependent and -independent activity

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12 December 2020

Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

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12 December 2020

Identifiers

DOI

10.1074/JBC.M110.145540

1 reference

2 August 2017

1 reference

2 August 2017

1 reference