Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation (Q34503909)

2 August 2017

Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation (English)

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2 August 2017

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3

Sloane JA

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ORCID Public Data File 2021

2 August 2017

5

Abraham CR

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2 August 2017

Yamin R

1

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2 August 2017

Malgeri EG

series ordinal

2

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2 August 2017

McGraw WT

series ordinal

4

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2 August 2017

language of work or name

English

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publication date

1 June 1999

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Journal of Biological Chemistry

2 August 2017

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2 August 2017

274

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2 August 2017

26

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2 August 2017

18777-18784

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

2 August 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

The alternatively spliced Kunitz protease inhibitor domain alters amyloid beta protein precursor processing and amyloid beta protein production in cultured cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Human brain peptidase activity with the specificity to generate the N-terminus of the Alzheimer β-amyloid protein from its precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Human thimet oligopeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Amyloid beta protein (A beta) removal by neuroglial cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

beta-Amyloid peptide produced in vitro is degraded by proteinases released by cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Aluminum-sensitive degradation of amyloid beta-protein 1-40 by murine and human intracellular enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Cathepsin D is involved in the clearance of Alzheimer's beta-amyloid protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Proteolysis of A beta peptide from Alzheimer disease brain by gelatinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Enhanced aggregation of beta-amyloid-containing peptides by extracellular matrix and their degradation by the 68 kDa serine protease prepared from human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

The serpin-enzyme complex receptor recognizes soluble, nontoxic amyloid-beta peptide but not aggregated, cytotoxic amyloid-beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Expression and characterization of human beta-secretase candidates metalloendopeptidase MP78 and cathepsin D in beta APP-overexpressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Examination of the role of endopeptidase 3.4.24.15 in A beta secretion by human transfected cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Immunocytochemical localization of endopeptidase 24.15 in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Alterations of peptide metabolism and neuropeptidase activity in senile dementia of the Alzheimer's type.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

A survey of the cerebral regionalization and ontogeny of eight exo- and endopeptidases in murines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Alzheimer's peptide Abeta1-42 binds to two beta-sheets of alpha1-antichymotrypsin and transforms it from inhibitor to substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

A soluble metalloendopeptidase from rat brain. Purification of the enzyme and determination of specificity with synthetic and natural peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Substrate specificity differences between recombinant rat testes endopeptidase EC 3.4.24.15 and the native brain enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Proteolytic degradation of Alzheimer's disease amyloid beta-peptide by a metalloproteinase from microglia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Monoclonal antibodies against the human metalloprotease EC 3.4.24.15 label neurofibrillary tangles in Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Influence of region-specific alterations of neuropeptidase content on the catabolic fates of neuropeptides in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

Evaluation of cathepsins D and G and EC 3.4.24.15 as candidate beta-secretase proteases using peptide and amyloid precursor protein substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

The presence of insulin-degrading enzyme in human ileal and colonic mucosal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.26.18777

21 January 2018

Identifiers

DOI

10.1074/JBC.274.26.18777

1 reference

2 August 2017

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