Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia (Q34504188)

2 August 2017

title

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia (English)

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2 August 2017

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Andrew W Roberts

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William G Wierda

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object named as

William G Wierda

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2 August 2017

Matthew S Davids

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John M Pagel

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Brad S Kahl

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Soham D Puvvada

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John F Gerecitano

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Thomas J Kipps

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Mary Ann Anderson

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Jennifer R Brown

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Lori Gressick

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Shekman Wong

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Martin Dunbar

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Ming Zhu

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Monali B Desai

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Elisa Cerri

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Sari Heitner Enschede

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Rod A Humerickhouse

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John F Seymour

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language of work or name

English

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publication date

6 December 2015

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The New England Journal of Medicine

2 August 2017

published in

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volume

374

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issue

4

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2 August 2017

page(s)

311-322

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Dose escalation methods in phase I cancer clinical trials

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cites work

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12 December 2020

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

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Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome

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Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia

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Long-term results of first salvage treatment in CLL patients treated initially with FCR (fludarabine, cyclophosphamide, rituximab)

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Relevance of the immunoglobulin VH somatic mutation status in patients with chronic lymphocytic leukemia treated with fludarabine, cyclophosphamide, and rituximab (FCR) or related chemoimmunotherapy regimens

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Etiology of Ibrutinib Therapy Discontinuation and Outcomes in Patients With Chronic Lymphocytic Leukemia

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Idelalisib and rituximab in relapsed chronic lymphocytic leukemia

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Programmed anuclear cell death delimits platelet life span.

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Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.

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Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia

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12 December 2020

Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

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Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib

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Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib

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Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins

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12 December 2020

Identifiers

DOI

10.1056/NEJMOA1513257

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2 August 2017

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