Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling (Q34506149)

2 August 2017

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling (English)

1 reference

2 August 2017

cognitive dysfunction

1 reference

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26692334%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Karen E Duff

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26692334%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Wai Haung Yu

5

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author name string

Natura Myeku

1

1 reference

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9 June 2020

Catherine L Clelland

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26692334%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Sheina Emrani

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26692334%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Nikolay V Kukushkin

4

1 reference

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9 June 2020

language of work or name

English

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publication date

21 December 2015

1 reference

2 August 2017

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9 June 2020

volume

22

1 reference

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9 June 2020

issue

1

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9 June 2020

page(s)

46-53

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26692334%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

9 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4787271/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nm.4011

0 references

cites work

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins.

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7 July 2018

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The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome.

7 July 2018

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Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system

7 July 2018

1 reference

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Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs

7 July 2018

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Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's disease

7 July 2018

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Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

7 July 2018

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cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons

7 July 2018

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Near-atomic resolution structural model of the yeast 26S proteasome.

7 July 2018

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The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

7 July 2018

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Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP.

7 July 2018

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Propagation of tau pathology in a model of early Alzheimer's disease

7 July 2018

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Trans-synaptic spread of tau pathology in vivo

7 July 2018

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Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

7 July 2018

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Complete subunit architecture of the proteasome regulatory particle

7 July 2018

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Keeping proteasomes under control--a role for phosphorylation in the nucleus

7 July 2018

1 reference

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Assessment of proteasome impairment and accumulation/aggregation of ubiquitinated proteins in neuronal cultures

7 July 2018

1 reference

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Proteasomal AAA-ATPases: structure and function.

7 July 2018

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Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry

7 July 2018

1 reference

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Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.

7 July 2018

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ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle

7 July 2018

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ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation

7 July 2018

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Enhancement of proteasome activity by a small-molecule inhibitor of USP14

7 July 2018

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Regulation of the autophagy protein LC3 by phosphorylation

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

Protein kinase A phosphorylation of tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrier

7 July 2018

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Proteomic analysis of protein phosphorylation and ubiquitination in Alzheimer's disease.

7 July 2018

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Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening

7 July 2018

1 reference

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Recognition and processing of ubiquitin-protein conjugates by the proteasome

7 July 2018

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Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation

7 July 2018

1 reference

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Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

Tau suppression in a neurodegenerative mouse model improves memory function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

Protein degradation and protection against misfolded or damaged proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

Selective degradation of ubiquitinated Sic1 by purified 26S proteasome yields active S phase cyclin-Cdk

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

7 July 2018

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Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

Developments of a water-maze procedure for studying spatial learning in the rat

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

PKA rapidly enhances proteasome assembly and activity in in vivo canine hearts

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

The synthesis and proteasomal degradation of a model substrate Ub5DHFR.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

A transgenic mouse model of the ubiquitin/proteasome system

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

Organotypic slice cultures from transgenic mice as disease model systems.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

Proteasomal degradation of tau protein

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4787271

Preparation of ubiquitinated substrates by the PY motif-insertion method for monitoring 26S proteasome activity

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26692334

12 December 2020

inferred from PubMed ID database lookup

Impaired proteasome function in Alzheimer's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26692334

12 December 2020

inferred from PubMed ID database lookup

Affinity purification of mammalian 26S proteasomes using an ubiquitin-like domain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26692334

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NM.4011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26692334%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

9 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26692334%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26692334%20AND%20SRC:MED&resulttype=core&format=json