NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells (Q34508406)

2 August 2017

title

NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells (English)

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2 August 2017

5

Daniel D Billadeau

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2 August 2017

Jadee L Upshaw

1

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2 August 2017

Laura N Arneson

2

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2 August 2017

Renee A Schoon

3

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2 August 2017

Christopher J Dick

4

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2 August 2017

Paul J Leibson

6

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2 August 2017

language of work or name

English

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publication date

2 April 2006

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2 August 2017

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2 August 2017

volume

7

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2 August 2017

issue

5

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2 August 2017

page(s)

524-532

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2 August 2017

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Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA

21 January 2018

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Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice

21 January 2018

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The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

21 January 2018

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NKG2D function protects the host from tumor initiation

21 January 2018

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IL-21 enhances tumor rejection through a NKG2D-dependent mechanism

21 January 2018

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DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor

21 January 2018

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Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts

21 January 2018

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Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells

21 January 2018

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Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.

21 January 2018

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An activating immunoreceptor complex formed by NKG2D and DAP10

21 January 2018

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A Structural basis for the association of DAP12 with mouse, but not human, NKG2D

21 January 2018

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NKG2D-DAP10 triggers human NK cell–mediated killing via a Syk-independent regulatory pathway

21 January 2018

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NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

21 January 2018

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The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure.

21 January 2018

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Novel recognition mode between Vav and Grb2 SH3 domains

21 January 2018

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21 January 2018

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SH2 domains recognize specific phosphopeptide sequences

21 January 2018

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Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling

21 January 2018

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The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors

21 January 2018

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Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain

21 January 2018

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Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes

21 January 2018

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Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity

21 January 2018

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CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase

21 January 2018

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Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells

21 January 2018

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T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif

21 January 2018

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T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras

21 January 2018

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CD28 is not directly involved in the response of human CD3- CD56+ natural killer cells to lipopolysaccharide: a role for T cells

21 January 2018

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SH2 domain-mediated targeting, but not localization, of Syk in the plasma membrane is critical for FcepsilonRI signaling

21 January 2018

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Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells.

21 January 2018

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Costimulation of multiple NK cell activation receptors by NKG2D.

21 January 2018

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The role of the NKG2D immunoreceptor in immune cell activation and natural killing

21 January 2018

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NKG2D is a costimulatory receptor for human naive CD8+ T cells.

21 January 2018

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Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation.

21 January 2018

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Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells

21 January 2018

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SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors

21 January 2018

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The Rho family guanine nucleotide exchange factor Vav-2 regulates the development of cell-mediated cytotoxicity

21 January 2018

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The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing

21 January 2018

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Solution structure of N-terminal SH3 domain of Vav and the recognition site for Grb2 C-terminal SH3 domain

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

B7-1 enhances natural killer cell-mediated cytotoxicity and inhibits tumor growth of a poorly immunogenic murine carcinoma

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Specific subdomains of Vav differentially affect T cell and NK cell activation

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NI1325

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Dimensions Publication ID

2 August 2017

1052763965

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