Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation (Q34510406)

2 August 2017

Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation (English)

1 reference

2 August 2017

0 references

1 reference

Yves Jossin

2

1 reference

ORCID Public Data File 2021

author name string

Hélène Servais

1

1 reference

2 August 2017

Françoise Van Bambeke

3

1 reference

2 August 2017

Paul M Tulkens

4

1 reference

2 August 2017

Marie-Paule Mingeot-Leclercq

5

1 reference

2 August 2017

language of work or name

English

0 references

publication date

1 April 2006

1 reference

Antimicrobial Agents and Chemotherapy

2 August 2017

1 reference

2 August 2017

50

1 reference

2 August 2017

4

1 reference

2 August 2017

1213-1221

1 reference

The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Cytotoxic chemotherapy upregulates pro-apoptotic Bax and Bak in the small intestine of rats and humans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

A prostacyclin analog prevents radiocontrast nephropathy via phosphorylation of cyclic AMP response element binding protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Role of Bcl-xL in paracetamol-induced tubular epithelial cell death.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Bcl-2 family members and disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Protein measurement with the Folin phenol reagent

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Role of apoptosis in hypoxic/ischemic damage in the kidney

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Bax translocation to mitochondria is an important event in inducing apoptotic cell death by indole-3-carbinol (I3C) treatment of breast cancer cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Adenovirus-mediated Bax overexpression for the induction of therapeutic apoptosis in prostate cancer.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Polycations induce the release of soluble intermembrane mitochondrial proteins.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Molecular mechanisms of apoptosis induced by cytotoxic chemicals

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Aminoglycosides: nephrotoxicity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Quantifying protein in 2-D PAGE solubilization buffers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Characterization of a kidney proximal tubule cell line, LLC-PK1, expressing endocytotic active megalin.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Tobacco smoke induces both apoptosis and necrosis in mammalian cells: differential effects of HSP70.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Movement of Bax from the cytosol to mitochondria during apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

A peptide sequence from Bax that converts Bcl-2 into an activator of apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

A rapid and versatile method to synthesize internal standards for competitive PCR

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Oxidative stress as a mediator of apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

LLC-PK1 epithelia as a model for in vitro assessment of proximal tubular nephrotoxicity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Increased renal DNA synthesis in vivo after administration of low doses of gentamicin to rats

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

The development of gamma-glutamyltransferase in a pig renal-epithelial-cell line in vitro. Relationship to amino acid transport

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Nephrotoxicity of gentamicin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

The use of kidney epithelial cell line (LLC-PK1) to study aminoglycoside nephrotoxicity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Retention of pinocytized solute by CHO cell lysosomes correlates with molecular weight

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Aminoglycoside-induced renal phospholipidosis and nephrotoxicity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Mechanism of protection afforded by polyaspartic acid against gentamicin-induced phospholipidosis. I. Polyaspartic acid binds gentamicin and displaces it from negatively charged phospholipid layers in vitro

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Renal proximal tubule cell cultures for studying drug-induced nephrotoxicity and modulation of phenotype expression by medium components

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Autoradiography of gentamicin uptake by the rat proximal tubule cell

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts. Quantitative ultrastructural and biochemical study

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

The renal handling of polybasic drugs. 1. Gentamicin and aprotinin in intact animals

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

The uptake and intracellular accumulation of aminoglycoside antibiotics in lysosomes of cultured rat fibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Fibrate prevents cisplatin-induced proximal tubule cell death

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Aggregates of oxidized proteins (lipofuscin) induce apoptosis through proteasome inhibition and dysregulation of proapoptotic proteins

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Direct inhibition of the ubiquitin-proteasome pathway by ester bond-containing green tea polyphenols is associated with increased expression of sterol regulatory element-binding protein 2 and LDL receptor

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

73-kDa molecular chaperone HSP73 is a direct target of antibiotic gentamicin

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Induction of G1 arrest and apoptosis in human jurkat T cells by pentagalloylglucose through inhibiting proteasome activity and elevating p27Kip1, p21Cip1/WAF1, and Bax proteins

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Diverse effects of nanosecond pulsed electric fields on cells and tissues

27 October 2018

1 reference

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Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Clusterin protects renal tubular epithelial cells from gentamicin-mediated cytotoxicity

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Role of megalin in renal handling of aminoglycosides

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1426926

Megalin Deficiency Offers Protection from Renal Aminoglycoside Accumulation

27 October 2018

1 reference

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Identification of the aminoglycoside binding site in rat renal brush border membranes

9 December 2018

1 reference

12 December 2020

Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies with gentamicin and amikacin

1 reference

12 December 2020

Interactions of Macrolide Antibiotics (Erythromycin A, Roxithromycin, Erythromycylamine [Dirithromycin], and Azithromycin) with Phospholipids: Computer-Aided Conformational Analysis and Studies on Acellular and Cell Culture Models

1 reference

12 December 2020

Quercetin inhibits the invasion and mobility of murine melanoma B16-BL6 cells through inducing apoptosis via decreasing Bcl-2 expression

1 reference

12 December 2020

Inhibitory activity of dome formation in LLC-PK1 cells is a selective index of aminoglycoside nephrotoxicity

1 reference

12 December 2020

Early effects of gentamicin, tobramycin, and amikacin on the human kidney

1 reference

12 December 2020

Experimental studies on nephrotoxicity of aminoglycosides at low doses. Mechanisms and perspectives

1 reference

12 December 2020

Impairment of lysosome-pinocytic vesicle fusion in rat kidney proximal tubules after treatment with gentamicin at low doses

1 reference

12 December 2020

Polyaspartic acid prevents experimental aminoglycoside nephrotoxicity

1 reference

12 December 2020

The application of renal cells in culture in studying drug-induced nephrotoxicity

1 reference

12 December 2020

In vivo antitumor effects of electrochemotherapy in a hepatoma model

1 reference

12 December 2020

Variation of heat shock protein 70 through the cell cycle in HL-60 cells and its relationship to apoptosis

1 reference

12 December 2020

Aminoglycoside antibiotics traffic to the Golgi complex in LLC-PK1 cells

1 reference

12 December 2020

Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts

1 reference

12 December 2020

Renal cell loss through cell suicide

1 reference

12 December 2020

Flow cytometry quantification of electropermeabilization

1 reference

12 December 2020

Overexpression of Bax Protein and Enhanced Apoptosis in the Left Ventricle of Spontaneously Hypertensive Rats

1 reference

12 December 2020

Gentamicin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum

1 reference

12 December 2020

10.1128/AAC.50.4.1213-1221.2006

Identifiers

DOI

1 reference

2 August 2017

1 reference

2 August 2017

1 reference