The genetic background of Parkinson's disease: current progress and future prospects (Q34513714)

2 August 2017

title

The genetic background of Parkinson's disease: current progress and future prospects (English)

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2 August 2017

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K Kalinderi

1

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2 August 2017

S Bostantjopoulou

series ordinal

2

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2 August 2017

L Fidani

series ordinal

3

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2 August 2017

language of work or name

English

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publication date

12 February 2016

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Acta Neurologica Scandinavica

2 August 2017

published in

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2 August 2017

volume

134

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2 August 2017

issue

5

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2 August 2017

page(s)

314-326

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Epidemiology of Parkinson's disease

2 August 2017

cites work

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The diagnosis of Parkinson's disease

21 January 2018

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Olfactory dysfunction in sporadic Parkinson's Disease and LRRK2 carriers

21 January 2018

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Parkinson's disease: from monogenic forms to genetic susceptibility factors

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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The use of next-generation sequencing in movement disorders

21 January 2018

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The role and challenges of exome sequencing in studies of human diseases

21 January 2018

1 reference

21 January 2018

Genetic linkage studies

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Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

21 January 2018

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Genetic analysis of families with Parkinson disease that carry the Ala53Thr mutation in the gene encoding alpha-synuclein

21 January 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

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α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?

21 January 2018

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G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome

21 January 2018

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A novel α-synuclein missense mutation in Parkinson disease

21 January 2018

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Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.

21 January 2018

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The many faces of alpha-synuclein mutations

21 January 2018

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Clinical and neuroimaging features of patient with early-onset Parkinson's disease with dementia carrying SNCA p.G51D mutation

21 January 2018

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Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications

21 January 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

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Alpha-synuclein gene rearrangements in dominantly inherited parkinsonism: frequency, phenotype, and mechanisms

21 January 2018

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

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What genetics tells us about the causes and mechanisms of Parkinson's disease

21 January 2018

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LRRK2 G2019S and R1441G mutations associated with Parkinson's disease are common in the Basque Country, but relative prevalence is determined by ethnicity.

21 January 2018

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Is the G2019S LRRK2 mutation common in all southern European populations?

21 January 2018

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The LRRK2 gene in Parkinson's disease: mutation screening in patients from Germany

21 January 2018

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Genetic screening for LRRK2 gene G2019S mutation in Parkinson's disease patients from Southern Italy

21 January 2018

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LRRK2 haplotype analyses in European and North African families with Parkinson disease: a common founder for the G2019S mutation dating from the 13th century

21 January 2018

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LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

21 January 2018

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Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations

21 January 2018

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LRRK2 in Parkinson's disease: genetic and clinical studies from patients

21 January 2018

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Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans

21 January 2018

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Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

21 January 2018

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LRRK2 R1441G in Spanish patients with Parkinson's disease.

21 January 2018

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Identification of a Japanese family with LRRK2 p.R1441G-related Parkinson's disease

21 January 2018

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Genetic diagnosis by whole exome capture and massively parallel DNA sequencing

21 January 2018

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A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

21 January 2018

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Frequency of the D620N mutation in VPS35 in Parkinson disease.

21 January 2018

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VPS35 mutations in Parkinson disease

21 January 2018

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D620N mutation in the VPS35 gene and R1205H mutation in the EIF4G1 gene are uncommon in the Greek population

21 January 2018

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The VPS35 gene and Parkinson's disease

21 January 2018

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

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A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease

21 January 2018

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Distribution, type, and origin of Parkin mutations: review and case studies

21 January 2018

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Lewy bodies and parkinsonism in families with parkin mutations

21 January 2018

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

21 January 2018

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A Ubl/ubiquitin switch in the activation of Parkin

21 January 2018

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

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Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes.

21 January 2018

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PINK1-linked parkinsonism is associated with Lewy body pathology.

21 January 2018

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Emerging pathways in genetic Parkinson's disease: autosomal-recessive genes in Parkinson's disease--a common pathway?

21 January 2018

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DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating Pink1.

21 January 2018

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A susceptibility locus for Parkinson's disease maps to chromosome 2p13.

21 January 2018

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The ubiquitin pathway in Parkinson's disease

21 January 2018

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A susceptibility gene for late-onset idiopathic Parkinson's disease

21 January 2018

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Significant linkage of Parkinson disease to chromosome 2q36-37

21 January 2018

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Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

21 January 2018

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

21 January 2018

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Translation initiator EIF4G1 mutations in familial Parkinson disease

21 January 2018

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The EIF4G1 gene and Parkinson's disease

21 January 2018

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DNAJC13 mutations in Parkinson disease

21 January 2018

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Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

21 January 2018

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Characterization of PLA2G6 as a locus for dystonia-parkinsonism

21 January 2018

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FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome

21 January 2018

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A deleterious mutation in DNAJC6 encoding the neuronal-specific clathrin-uncoating co-chaperone auxilin, is associated with juvenile parkinsonism

21 January 2018

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The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive Parkinsonism with generalized seizures

21 January 2018

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Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset Parkinsonism

21 January 2018

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Genetic association studies

21 January 2018

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Genome-wide association studies in neurological disorders

21 January 2018

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Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease

21 January 2018

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Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

21 January 2018

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Association of GWAS loci with PD in China

21 January 2018

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Assessment of Parkinson's disease risk loci in Greece

21 January 2018

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Association studies of sporadic Parkinson's disease in the genomic era.

21 January 2018

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Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system

21 January 2018

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Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain.

21 January 2018

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Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene

21 January 2018

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Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease

21 January 2018

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SNCA variant associated with Parkinson disease and plasma alpha-synuclein level

21 January 2018

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Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database

21 January 2018

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From 1997 to 2007: a decade journey through the H1 haplotype on 17q21 chromosome

21 January 2018

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Tau haplotypes regulate transcription and are associated with Parkinson's disease.

21 January 2018

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The Tau Gene Haplotype H1 Confers a Susceptibility to Parkinson’s Disease

21 January 2018

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Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia

21 January 2018

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Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

21 January 2018

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Milestones in PD genetics

21 January 2018

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Occurrence of Parkinson's syndrome in type I Gaucher disease

21 January 2018

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Parkinsonism among Gaucher disease carriers

21 January 2018

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Glucocerebrosidase mutations and the pathogenesis of Parkinson disease

21 January 2018

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Complete screening for glucocerebrosidase mutations in Parkinson disease patients from Greece

21 January 2018

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Complete screening for glucocerebrosidase mutations in Parkinson disease patients from Portugal

21 January 2018

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Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.

21 January 2018

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The significance of GBA for Parkinson's disease

21 January 2018

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SMPD1 mutations and Parkinson disease.

21 January 2018

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Parkinsonism syndrome in heterozygotes for Niemann-Pick C1.

21 January 2018

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C9orf72 repeat expansions are a rare genetic cause of parkinsonism

21 January 2018

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Global investigation and meta-analysis of the C9orf72 (G4C2)n repeat in Parkinson disease

21 January 2018

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Pathogenic mechanisms of neurodegeneration in Parkinson disease

21 January 2018

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Candidate genes for Parkinson disease: Lessons from pathogenesis

21 January 2018

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Genetic causes of Parkinson's disease and their links to autophagy regulation

21 January 2018

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

21 January 2018

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Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.

21 January 2018

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Interplay of LRRK2 with chaperone-mediated autophagy

21 January 2018

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Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease

21 January 2018

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Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity

21 January 2018

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Synaptojanin 1 is required for endolysosomal trafficking of synaptic proteins in cone photoreceptor inner segments

21 January 2018

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The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy

21 January 2018

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Analysis of the Retromer complex-WASH complex interaction illuminates new avenues to explore in Parkinson disease

21 January 2018

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LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase

21 January 2018

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RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

21 January 2018

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Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

21 January 2018

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EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson's disease

21 January 2018

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Usefulness of Genetic Testing in PD and PD Trials: A Balanced Review

21 January 2018

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Genomics and bioinformatics of Parkinson's disease

21 January 2018

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Pharmacological treatment and the prospect of pharmacogenetics in Parkinson's disease

21 January 2018

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LAMP2A as a therapeutic target in Parkinson disease

21 January 2018

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Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families

21 January 2018

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LRRK2 and Parkinson?s disease in Norway

21 January 2018

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LRRK2G2019S as a Cause of Parkinson's Disease in North African Arabs

21 January 2018

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A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/ANE.12563

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2 August 2017

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