Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys (Q34516555)

29 September 2017

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys (English)

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29 September 2017

Orthoebolavirus zairense

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4

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Michael K Lo

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Sina Bavari

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Sina Bavari

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Stuart T Nichol

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Rouzbeh Zamani

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Brett P Eaton

Brett P Eaton

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Catherine L Wilhelmsen

Catherine L Wilhelmsen

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Tomáš Cihlář

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Tomas Cihlar

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Richard L Mackman

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Veronica Soloveva

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Robert Jordan

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Dustin Siegel

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Willard Lew

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Edward Doerffler

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Christina F Spiropoulou

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Christina F Spiropoulou

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Dima Gharaibeh

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Tara Kenny

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Cary J Retterer

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Roy Bannister

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Robert Strickley

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Sean A Van Tongeren

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Ginger Donnelly

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Lisa S Welch

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Jonathan E Nuss

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Ernest Carra

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Queenie Wang

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Lydia Wolfe

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Kirsten M Stray

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Joy Y Feng

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Ona Barauskas

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Mike Flint

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Donald K Nichols

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Travis K Warren

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Michel Perron

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Hon C Hui

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Nate Larson

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Jay Wells

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Kelly S Stuthman

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Nicole L Garza

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Amy C Shurtleff

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Elizabeth Grimes

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Laura Gomba

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Elyse R Nagle

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Jeffrey R Kugelman

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Sean Neville

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Michael O Clarke

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Lijun Zhang

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Bruce Ross

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Kwon Chun

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Darius Babusis

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Yeojin Park

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Iva Trancheva

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Yili Xu

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Pamela Wong

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Molly R Braun

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Laura K McMullan

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Shan-Shan Chen

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Rachel Fearns

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Swami Swaminathan

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Douglas L Mayers

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William A Lee

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29 September 2017

language of work or name

English

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publication date

2 March 2016

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29 September 2017

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531

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7594

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29 September 2017

381-385

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https://scigraph.springernature.com/pub.10.1038/nature17180

29 September 2017

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cites work

The lipid moiety of brincidofovir is required for in vitro antiviral activity against Ebola virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors - Preliminary Report

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Molecular evidence of sexual transmission of Ebola virus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Structural Analysis of Monomeric RNA-Dependent Polymerases: Evolutionary and Therapeutic Implications

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Emergence of Ebola Virus Escape Variants in Infected Nonhuman Primates Treated with the MB-003 Antibody Cocktail

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Clinical presentation, biochemical, and haematological parameters and their association with outcome in patients with Ebola virus disease: an observational cohort study

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Respiratory Syncytial Virus Inhibitor AZ-27 Differentially Inhibits Different Polymerase Activities at the Promoter

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Persistence of Ebola Virus in Ocular Fluid during Convalescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Characterization of clinical and immunological parameters during Ebola virus infection of rhesus macaques

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Euthanasia assessment in ebola virus infected nonhuman primates

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

High-throughput, luciferase-based reverse genetics systems for identifying inhibitors of Marburg and Ebola viruses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Post-exposure efficacy of oral T-705 (Favipiravir) against inhalational Ebola virus infection in a mouse model

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Respiratory syncytial virus polymerase can initiate transcription from position 3 of the leader promoter

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Ebola virus genome plasticity as a marker of its passaging history: a comparison of in vitro passaging to non-human primate infection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Identification of multiple rate-limiting steps during the human mitochondrial transcription cycle in vitro

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Nucleotide analogue prodrug tenofovir disoproxil enhances lymphoid cell loading following oral administration in monkeys

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Filoviruses. A compendium of 40 years of epidemiological, clinical, and laboratory studies.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

The Mechanism of Action of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine Involves a Second Metabolic Pathway Leading to -D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine 5'-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Human microvascular endothelial cells immortalized with human telomerase catalytic protein: a model for the study of in vitro angiogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Polyadenylation-dependent screening assay for respiratory syncytial virus RNA transcriptase activity and identification of an inhibitor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5551389

Sequelae of Ebola Virus Disease, Kenema District, Sierra Leone

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE17180

Infectious diseases. Ebola drug trials lurch ahead

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE17180

Species difference of esterase expression and hydrolase activity in plasma

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26934220

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE17180

1 reference

Dimensions Publication ID

29 September 2017

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1 reference

29 September 2017

1 reference