The therapeutic potential of inhibitors of the trypanothione cycle (Q34519134)

2 August 2017

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title

The therapeutic potential of inhibitors of the trypanothione cycle (English)

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2 August 2017

Claudius D'Silva

1

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2 August 2017

Sylvie Daunes

series ordinal

2

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2 August 2017

language of work or name

English

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publication date

1 February 2002

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Expert Opinion on Investigational Drugs

2 August 2017

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2 August 2017

11

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2 August 2017

2

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2 August 2017

217-231

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The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes

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Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

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An analog of myristic acid with selective toxicity for African trypanosomes

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Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.

21 January 2018

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Enzymes of parasite thiol metabolism as drug targets

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Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases

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Cloning, sequencing, and demonstration of polymorphism in trypanothione reductase from Crithidia fasciculata

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Trypanothione reductase of Trypanosoma congolense: gene isolation, primary sequence determination, and comparison to glutathione reductase

21 January 2018

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Cloning, sequencing, overproduction and purification of trypanothione reductase from Trypanosoma cruzi.

21 January 2018

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Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

21 January 2018

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Substrate interactions between trypanothione reductase and N1-glutathionylspermidine disulphide at 0.28-nm resolution

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Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures

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Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents

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Comparison of resin and solution screening methodologies in combinatorial chemistry and the identification of a 100 nM inhibitor of trypanothione reductase

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Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine

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Interaction of AZA analogs of chlorpromazine with the dopamine D2 receptor.

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Potent and specific inhibitors of trypanothione reductase from Trypanosoma cruzi: bis(2-aminodiphenylsulfides) for fluorescent labeling studies

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"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease

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2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

21 January 2018

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Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies

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Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata

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Trypanosoma brucei tryparedoxin, a thioredoxin-like protein in African trypanosomes.

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Subcellular distribution of trypanothione reductase in bloodstream and procyclic forms of Trypanosoma brucei.

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Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi

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Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei

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The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I

21 January 2018

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Photo-labelling of glutaredoxin from Escherichia coli

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Role of the N-terminus of glutathione in the action of yeast glyoxalase I

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QSAR study on the contribution of log P and E(s) to the in vitro antiprotozoal activity of glutathione derivatives

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Glutathione derivatives active against Trypanosoma brucei rhodesiense and T. brucei brucei in vitro

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Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata

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Synthesis of N-benzyloxycarbonyl-l-cysteinylglycine 3-dimethylaminopropylamide disulfide: A cheap and convenient new assay for trypanothione reductase

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Bimane cyclic esters, possible stereologues of trypanothione as antitrypanosomal agents. Bimanes 29

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10.1517/13543784.11.2.217

21 January 2018

Identifiers

DOI

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release_m4px53nhbzc3fo7azu5v3t3a54

2 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/m4px53nhbzc3fo7azu5v3t3a54

mapped directly with Wikidata item

24 November 2022

based on heuristic

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