Possible physiological roles of mitochondrial uncoupling proteins--UCPn (Q34525469)

2 August 2017

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title

Possible physiological roles of mitochondrial uncoupling proteins--UCPn (English)

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2 August 2017

Petr Jezek

1

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2 August 2017

publication date

1 October 2002

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International Journal of Biochemistry & Cell Biology

2 August 2017

published in

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2 August 2017

volume

34

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2 August 2017

issue

10

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2 August 2017

page(s)

1190-1206

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The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

2 August 2017

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Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

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Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR

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13C/31P NMR assessment of mitochondrial energy coupling in skeletal muscle of awake fed and fasted rats. Relationship with uncoupling protein 3 expression.

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Transport function and regulation of mitochondrial uncoupling proteins 2 and 3

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7 January 2021

Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)

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7 January 2021

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

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7 January 2021

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

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7 January 2021

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action

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Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis

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A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans

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Up-regulation of uncoupling proteins by beta-adrenergic stimulation in L6 myotubes

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Possible role of uncoupling protein in regulation of myocardial energy metabolism in aortic regurgitation model rats.

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Fatty acid interaction with mitochondrial uncoupling proteins

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Structure and function of the uncoupling protein from brown adipose tissue

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Specific sequence of motifs of mitochondrial uncoupling proteins

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7 January 2021

Mitochondrial uncoupling proteins and phylogenesis--UCP4 as the ancestral uncoupling protein.

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7 January 2021

Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis

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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

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Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression

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7 January 2021

UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue

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7 January 2021

Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin

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7 January 2021

BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast

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7 January 2021

UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells

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7 January 2021

Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation

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7 January 2021

PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth

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7 January 2021

Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells.

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7 January 2021

Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats

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7 January 2021

Up-regulation of liver uncoupling protein-2 mRNA by either fish oil feeding or fibrate administration in mice

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7 January 2021

Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates

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7 January 2021

Increased uncoupling protein2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linolenic acid

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7 January 2021

Increase in uncoupling protein-2 mRNA expression by BRL49653 and bromopalmitate in human adipocytes.

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7 January 2021

Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression

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7 January 2021

The regulation of uncoupling protein-2 gene expression by omega-6 polyunsaturated fatty acids in human skeletal muscle cells involves multiple pathways, including the nuclear receptor peroxisome proliferator-activated receptor beta

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7 January 2021

Transcriptional regulation of the mouse uncoupling protein-2 gene. Double E-box motif is required for peroxisome proliferator-activated receptor-gamma-dependent activation.

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7 January 2021

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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7 January 2021

Up-regulation of uncoupling protein-3 by fatty acid in C2C12 myotubes

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7 January 2021

Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart

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7 January 2021

Chronic docosahexaenoic acid intake enhances expression of the gene for uncoupling protein 3 and affects pleiotropic mRNA levels in skeletal muscle of aged C57BL/6NJcl mice

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7 January 2021

9-cis Retinoic acid induces the expression of the uncoupling protein-2 gene in brown adipocytes

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7 January 2021

Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation

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7 January 2021

Leptin regulation of peroxisome proliferator-activated receptor-gamma, tumor necrosis factor, and uncoupling protein-2 expression in adipose tissues

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7 January 2021

Uncoupling protein-3: a muscle-specific gene upregulated by leptin in ob/ob mice

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7 January 2021

Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins

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7 January 2021

UCP2, UCP3 and leptin gene expression: modulation by food restriction and leptin.

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7 January 2021

Downregulation of uncoupling protein 2 mRNA in white adipose tissue and uncoupling protein 3 mRNA in skeletal muscle during the early stages of leptin treatment

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7 January 2021

Induction of UCP2 gene expression by LPS: a potential mechanism for increased thermogenesis during infection.

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7 January 2021

Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-alpha-dependent mechanism

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7 January 2021

Increased uncoupling protein-2 gene expression in brain of lipopolysaccharide-injected mice: role of tumour necrosis factor-alpha?

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7 January 2021

In the rat, tumor necrosis factor α administration results in an increase in both UCP2 and UCP3 mRNAs in skeletal muscle: a possible mechanism for cytokine-induced thermogenesis?

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7 January 2021

Tumor necrosis factor-alpha regulates in vivo expression of the rat UCP family differentially

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7 January 2021

Induction of UCP2 mRNA by thyroid hormones in rat heart

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7 January 2021

Enhanced expression of uncoupling protein 2 gene in rat white adipose tissue and skeletal muscle following chronic treatment with thyroid hormone

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7 January 2021

Regulation of the third member of the uncoupling protein family, UCP3, by cold and thyroid hormone

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7 January 2021

Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle

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7 January 2021

Insulin-like Growth Factor Type 1 Upregulates Uncoupling Protein 3

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7 January 2021

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

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7 January 2021

Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3

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7 January 2021

Energy metabolism in uncoupling protein 3 gene knockout mice

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7 January 2021

In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism

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7 January 2021

Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism.

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7 January 2021

UCP2 muscle gene transfer modifies mitochondrial membrane potential

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7 January 2021

Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion

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7 January 2021

Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2.

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7 January 2021

Properties of the human long and short isoforms of the uncoupling protein-3 expressed in yeast cells

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7 January 2021

Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system

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7 January 2021

Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous expression system

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7 January 2021

Chimeric proteins between UCP1 and UCP3: the middle third of UCP1 is necessary and sufficient for activation by fatty acids

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7 January 2021

Inactive fatty acids are unable to flip-flop across the lipid bilayer

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7 January 2021

A structure-activity study of fatty acid interaction with mitochondrial uncoupling protein

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7 January 2021

Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation

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7 January 2021

On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein

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7 January 2021

Alkylsulfonates as probes of uncoupling protein transport mechanism. Ion pair transport demonstrates that direct H(+) translocation by UCP1 is not necessary for uncoupling.

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7 January 2021

A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation

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7 January 2021

Superoxide activates mitochondrial uncoupling proteins

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7 January 2021

Coenzyme Q is an obligatory cofactor for uncoupling protein function

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7 January 2021

Uncoupling: new approaches to an old problem of bioenergetics

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7 January 2021

Uncoupling Protein-2 Participates in Cellular Defense against Oxidative Stress in Clonal β-Cells

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7 January 2021

Reduced gene expression of UCP2 but not UCP3 in skeletal muscle of human obese subjects

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7 January 2021

Uncoupling protein-2 gene: reduced mRNA expression in intraperitoneal adipose tissue of obese humans

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7 January 2021

The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency

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7 January 2021

Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians.

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7 January 2021

Associations between uncoupling protein 2, body composition, and resting energy expenditure in lean and obese African American, white, and Asian children

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7 January 2021

Uncoupling protein 3 and peroxisome proliferator-activated receptor gamma2 contribute to obesity and diabetes in palauans

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7 January 2021

Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes

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7 January 2021

Concepts of fever: recent advances and lingering dogma

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7 January 2021

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

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7 January 2021

Mitochondrial uncoupling: role of uncoupling protein anion carriers and relationship to thermogenesis and weight control "the benefits of losing control".

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7 January 2021

Alteration of heart uncoupling protein-2 mRNA regulated by sympathetic nerve and triiodothyronine during postnatal period in rats.

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7 January 2021

10.1016/S1357-2725(02)00061-4

Identifiers

DOI

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2 August 2017

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