The modular logic of signaling proteins: building allosteric switches from simple binding domains (Q34525887)

2 August 2017

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title

The modular logic of signaling proteins: building allosteric switches from simple binding domains (English)

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2 August 2017

Wendell A Lim

1

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2 August 2017

1 February 2002

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Current Opinion in Structural Biology

2 August 2017

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2 August 2017

12

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2 August 2017

1

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2 August 2017

61-68

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Modular binding domains in signal transduction proteins

2 August 2017

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https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Protein modules and signalling networks

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https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Initial sequencing and analysis of the human genome

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https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Structures of Src-family tyrosine kinases

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https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Cellular functions regulated by Src family kinases

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https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

SH2/SH3 signaling proteins

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https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

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https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

SH2- and SH3-mediated interactions between focal adhesion kinase and Src.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

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https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins

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https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Actin assembly mediated by Arp2/3 complex and WASP family proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

The Wiskott-Aldrich syndrome protein (WASP) family

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection

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https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Rho GTPases and the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Crystal structure of the tyrosine phosphatase SHP-2

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https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Crystal structure of the Src family tyrosine kinase Hck

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Three-dimensional structure of the tyrosine kinase c-Src

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Improving SH3 domain ligand selectivity using a non-natural scaffold

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

A homochiral metal-organic porous material for enantioselective separation and catalysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Structure of Cdc42 bound to the GTPase binding domain of PAK

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Conformational switch and role of phosphorylation in PAK activation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Tandem SH2 domains confer high specificity in tyrosine kinase signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Intramolecular regulatory interactions in the Src family kinase Hck probed by mutagenesis of a conserved tryptophan residue.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis

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https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

Evolution of novel genes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

The stereochemical mechanism of the cooperative effects in hemoglobin revisited.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2802%2900290-7

7 January 2021

10.1016/S0959-440X(02)00290-7

Identifiers

DOI

1 reference

2 August 2017

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PubMed ID

11839491