Pterin transport and metabolism in Leishmania and related trypanosomatid parasites (Q34534653)

2 August 2017

1 reference

title

Pterin transport and metabolism in Leishmania and related trypanosomatid parasites (English)

1 reference

2 August 2017

Marc Ouellette

1

1 reference

2 August 2017

Jolyne Drummelsmith

2

1 reference

2 August 2017

Amal El-Fadili

3

1 reference

2 August 2017

Christoph Kündig

4

1 reference

2 August 2017

Dave Richard

5

1 reference

2 August 2017

Gaétan Roy

6

1 reference

2 August 2017

1 April 2002

1 reference

International Journal for Parasitology

2 August 2017

1 reference

2 August 2017

32

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2 August 2017

4

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2 August 2017

385-398

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Presence of methylenetetrahydrofolate reductase of American Leishmania species and its absence from Trypanosoma species

2 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Isolation of a nitric oxide synthase from the protozoan parasite, Leishmania donovani.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Nutritional requirements of wild-type and folate transport-deficient Leishmania donovani for pterins and folates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Biopterin conversion to reduced folates by Leishmania donovani promastigotes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Recurrent de novo appearance of small linear DNAs in Leishmania major and relationship to extra-chromosomal DNAs in other species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Life in vacuoles--nutrient acquisition by Leishmania amastigotes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Purification and partial characterization of three isoforms of serine hydroxymethyltransferase from Crithidia fasciculata

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Purification and some properties of serine hydroxymethyltransferase from Trypanosoma cruzi

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Mutant PTR1 proteins from Leishmania tarentolae: comparative kinetic properties and active-site labeling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Amplification of the H locus in Leishmania infantum.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Novel inhibitors of Leishmanial dihydrofolate reductase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Double targeted gene replacement for creating null mutants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Plasticity in chromosome number and testing of essential genes in Leishmania by targeting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

DNA amplification in arsenite-resistant Leishmania

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Impaired drug uptake in methotrexate resistant Crithidia fasciculata without changes in dihydrofolate reductase activity or gene amplification

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Immunization with recombinant LD1 antigens protects against experimental leishmaniasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Dihydrofolate reductase: thymidylate synthase, a bifunctional polypeptide from Crithidia fasciculata

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Tetrahydropterin-dependent amino acid hydroxylases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

P-glycoprotein overexpression in methotrexate-resistant Leishmania tropica

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

A novel interaction of the Golgi complex with the vimentin intermediate filament cytoskeleton

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

A new VSG expression site-associated gene (ESAG) in the promoter region of Trypanosoma brucei encodes a protein with 10 potential transmembrane domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Formation of extrachromosomal circular amplicons with direct or inverted duplications in drug-resistant Leishmania tarentolae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica: sequence homology with the corresponding monofunctional proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

The G alpha subunit G alpha 4 couples to pterin receptors and identifies a signaling pathway that is essential for multicellular development in Dictyostelium

7 January 2021

1 reference

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Amplification of the ABC transporter gene PGPA and increased trypanothione levels in potassium antimonyl tartrate (SbIII) resistant Leishmania tarentolae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Purine and pyrimidine metabolism in the Trypanosomatidae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Leishmaniasis: current status of vaccine development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Dihydropteridine reductase and tetrahydropterin in Crithidia fasciculata cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Use of amphotericin B in drug-resistant cases of visceral leishmaniasis in north Bihar, India.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Short-chain dehydrogenases/reductases (SDR)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Dependence of an alkyl glycol-ether monooxygenase activity upon tetrahydropterins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

RELATIONSHIP BETWEEN PYRIMIDINE AND LIPID BIOSYNTHESIS AND UNCONJUGATED PTERIDINE

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

The growth and nutrition of Crithidia fasciculata

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

A structural comparison of molybdenum cofactor-containing enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Antioxidative activity of 5,6,7,8-tetrahydrobiopterin and its inhibitory effect on paraquat-induced cell toxicity in cultured rat hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Resistance to methotrexate due to AcrAB-dependent export from Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Characterization of de novo folate synthesis in Pneumocystis carinii and Toxoplasma gondii: potential for screening therapeutic agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Residues involved in co-factor and substrate binding of the short-chain dehydrogenase/reductase PTR1 producing methotrexate resistance in Leishmania.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Substrate channeling and domain-domain interactions in bifunctional thymidylate synthase-dihydrofolate reductase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Evidence that the High Incidence of Treatment Failures in Indian Kala‐Azar Is Due to the Emergence of Antimony‐Resistant Strains ofLeishmania donovani

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Golgi GDP-mannose uptake requires Leishmania LPG2. A member of a eukaryotic family of putative nucleotide-sugar transporters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Catalysis by nitric oxide synthase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Treatment of visceral leishmaniasis (kala-azar): a decade of progress and future approaches

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

An amplified DNA element in Leishmania encodes potential integral membrane and nucleotide-binding proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Serine hydroxymethyltransferase activity in Trypanosoma cruzi, Trypanosoma rangeli and American Leishmania spp.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Radioassay of the folate-hydrolyzing enzyme activity, and the distribution of the enzyme in biological cells and tissues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

The amplified H circle of methotrexate-resistant leishmania tarentolae contains a novel P-glycoprotein gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Antifolate resistance mechanisms from bacteria to cancer cells with emphasis on parasites.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Reduced infectivity of a Leishmania donovani biopterin transporter genetic mutant and its use as an attenuated strain for vaccination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

A novel antifolate resistance gene on the amplified H circle of Leishmania.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

In vitro activity of sulfonamides and sulfones against Leishmania major promastigotes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Amplified DNAs in laboratory stocks of Leishmania tarentolae: extrachromosomal circles structurally and functionally similar to the inverted-H-region amplification of methotrexate-resistant Leishmania major

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Adaptation of Leishmania cells to in vitro culture results in a more efficient reduction and transport of biopterin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Aberrant folate response and premature development in a mutant of Dictyostelium discoideum.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Folylpolyglutamates in Leishmania major

7 January 2021

1 reference

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Identification of efflux systems for large anions and anionic conjugates as the mediators of methotrexate efflux in L1210 Cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Folate utilisation by Leishmania species and the identification of intracellular derivatives and folate-metabolising enzymes

7 January 2021

1 reference

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LD1 amplifications in Leishmania

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines

7 January 2021

1 reference

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Protective immunity against the protozoan Leishmania chagasi is induced by subclinical cutaneous infection with virulent but not avirulent organisms.

7 January 2021

1 reference

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Failure of pentavalent antimony in visceral leishmaniasis in India: report from the center of the Indian epidemic

7 January 2021

1 reference

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Tetrahydrobiopterin biosynthesis, regeneration and functions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Development of a safe live Leishmania vaccine line by gene replacement.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Pteridine Requirement of the HemoflagellateLeishmania tarentolae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

A DNA sequence (LD1) which occurs in several genomic organizations in Leishmania

7 January 2021

1 reference

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The lipophosphoglycan of Leishmania parasites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases

7 January 2021

1 reference

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Oxidative activity of primaquine metabolites on rat erythrocytes in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Investigation of the early steps of molybdopterin biosynthesis in Escherichia coli through the use of in vivo labeling studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Dihydrofolate reductase: a potential drug target in trypanosomes and leishmania.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

Compartmentation of folate-mediated one-carbon metabolism in eukaryotes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

inferred from DOI database lookup

7 January 2021

based on heuristic

Quantitative in vitro drug potency and drug susceptibility evaluation of Leishmania ssp. from patients unresponsive to pentavalent antimony therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

inferred from DOI database lookup

7 January 2021

based on heuristic

Frequent amplification of a short chain dehydrogenase gene in methotrexate resistant Leishmania

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2801%2900346-0

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0020-7519(01)00346-0

1 reference

2 August 2017

1 reference