Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers (Q34534818)

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English	Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers	scientific article

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scholarly article

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2 October 2017

Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers (English)

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Europe PubMed Central

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2 October 2017

Craig W. Lindsley

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Craig W Lindsley

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2 October 2017

Colleen M. Niswender

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Colleen M Niswender

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2 October 2017

P. Jeffrey Conn

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P Jeffrey Conn

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2 October 2017

Corey R. Hopkins

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Corey R Hopkins

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2 October 2017

Alice L. Rodriguez

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Alice L Rodriguez

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2 October 2017

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Michael Bubser

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2 October 2017

Darren W. Engers

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Darren W Engers

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2 October 2017

Anna Louise Blobaum

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Anna L Blobaum

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2 October 2017

Analisa D Thompson Gray

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Analisa Thompson Gray

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2 October 2017

9

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Matthew T Loch

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2 October 2017

2

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Carrie K Jones

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2 October 2017

author name string

Xin Lin

3

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2 October 2017

J Scott Daniels

10

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2 October 2017

Jonathan A Javitch

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2 October 2017

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publication date

21 July 2016

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2 October 2017

ACS Chemical Neuroscience

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2 October 2017

7

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2 October 2017

9

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Europe PubMed Central

PMC publication ID

2 October 2017

1201-1211

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2 October 2017

Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4).

1 reference

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The treatment of Parkinson's disease with deep brain stimulation: current issues

1 reference

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Distinct effects of mGlu4 receptor positive allosteric modulators at corticostriatal vs. striatopallidal synapses may differentially contribute to their antiparkinsonian action.

1 reference

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Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS

1 reference

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Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor

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A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease

1 reference

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Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers

1 reference

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Metabotropic glutamate receptor 4 in the basal ganglia of parkinsonian monkeys: ultrastructural localization and electrophysiological effects of activation in the striatopallidal complex

1 reference

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Synergy between L-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: implications for Parkinson's disease treatment and dyskinesia

1 reference

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7 July 2018

Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6-hydroxydopamine rat model of Parkinson's disease

1 reference

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A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential

1 reference

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7 July 2018

The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

1 reference

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7 July 2018

Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate recept

1 reference

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CODA-RET reveals functional selectivity as a result of GPCR heteromerization

1 reference

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Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats

1 reference

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A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors.

1 reference

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Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism.

1 reference

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Neurobiology and treatment of Parkinson's disease

1 reference

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7 July 2018

Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.

1 reference

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Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy

1 reference

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7 July 2018

Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease

1 reference

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7 July 2018

Metabotropic glutamate receptors in the basal ganglia motor circuit

1 reference

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A model of L-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal function

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Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

1 reference

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(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

1 reference

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Group III metabotropic glutamate receptor-mediated modulation of the striatopallidal synapse.

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Localization and physiological roles of metabotropic glutamate receptors in the direct and indirect pathways of the basal ganglia

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Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS

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Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia

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Activation of group III metabotropic glutamate receptors depresses glutamatergic transmission at corticostriatal synapse

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Treatment of advanced Parkinson's disease.

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Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1 reference

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Group III metabotropic glutamate-receptor-mediated modulation of excitatory transmission in rodent substantia nigra pars compacta dopamine neurons

1 reference

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Activation of group III metabotropic glutamate receptors in selected regions of the basal ganglia alleviates akinesia in the reserpine-treated rat.

1 reference

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Supersensitivity to apomorphine following destruction of the ascending dopamine neurons: Quantification using the rotational model

1 reference

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based on heuristic

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Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/27441572

12 December 2020

based on heuristic

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CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/27441572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/ACSCHEMNEURO.6B00036

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 October 2017

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