EM-652 (SCH57068), a pure SERM having complete antiestrogenic activity in the mammary gland and endometrium (Q34535264)

2 August 2017

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title

EM-652 (SCH57068), a pure SERM having complete antiestrogenic activity in the mammary gland and endometrium (English)

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2 August 2017

5

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2 August 2017

4

Simard J

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2 August 2017

Labrie F

1

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2 August 2017

Labrie C

2

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2 August 2017

Bélanger A

3

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2 August 2017

Tremblay A

6

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2 August 2017

Tremblay G

7

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2 August 2017

1 December 2001

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The Journal of Steroid Biochemistry and Molecular Biology

2 August 2017

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2 August 2017

79

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2 August 2017

1-5

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2 August 2017

213-225

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2 August 2017

Cancer statistics, 2000.

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Effects of estradiol and prolactin on steroid receptor levels in 7,12-dimethylbenz(a)anthracene-induced mammary tumors and uterus in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Control of aromatase in breast cancer cells and its importance for tumor growth

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Fundamental research leading to improved endocrine therapy for breast cancer

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

1 reference

7 January 2021

DHEA and peripheral androgen and estrogen formation: intracinology

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7 January 2021

Synthesis and biological activity of new halo-steroidal antiestrogens

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Inhibitory effect of a steroidal antiestrogen (EM-170) on estrone-stimulated growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Biology and mode of action of pure antioestrogens

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Mechanisms of antihormone action

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Long-term tamoxifen adjuvant therapy in node-positive breast cancer: a metabolic and pilot clinical study

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Risk and prognosis of endometrial cancer after tamoxifen for breast cancer. Comprehensive Cancer Centres' ALERT Group. Assessment of Liver and Endometrial cancer Risk following Tamoxifen

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

The future of new pure antiestrogens in clinical breast cancer

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

ICI 182,780, a new antioestrogen with clinical potential

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Sequence and characterization of a coactivator for the steroid hormone receptor superfamily

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Functional domains of the human estrogen receptor

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Dopaminergic and Ligand-Independent Activation of Steroid Hormone Receptors

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence

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https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Control of Hormone Receptor Levels and Growth of 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors by Estrogens, Progesterone and Prolactin

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Inhibitory effects of medroxyprogesterone acetate (MPA) and the pure antiestrogen EM-219 on estrone (E1)-stimulated growth of dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Controlled release low dose medroxyprogesterone acetate (MPA) inhibits the development of mammary tumors induced by dimethyl-benz(a) anthracene in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Additive inhibitory effects of bromocryptine (CB-154) and medroxyprogesterone acetate (MPA) on dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Prevention by dehydroepiandrosterone of the development of mammary carcinoma induced by 7,12-dimethylbenz(a)anthracene (DMBA) in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Comparative effects of 28-day treatment with the new anti-estrogen EM-800 and tamoxifen on estrogen-sensitive parameters in intact mice

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Combined effects of dehydroepiandrosterone and EM-800 on bone mass, serum lipids, and the development of dimethylbenz(A)anthracene-induced mammary carcinoma in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Inhibitory effect of the novel anti-estrogen EM-800 and medroxyprogesterone acetate on estrone-stimulated growth of dimethylbenz[a]anthracene-induced mammary carcinoma in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

(S)-(+)-4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)-ethoxy]phenyl]-2H-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): a highly potent, specific, and orally active nonsteroidal antiestrogen

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Characterization of the effects of the novel non-steroidal antiestrogen EM-800 on basal and estrogen-induced proliferation of T-47D, ZR-75-1 and MCF-7 human breast cancer cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Prevention of development of dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in the rat by the new nonsteroidal antiestrogen EM-800 (SCH57050).

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Antitumor effects of droloxifene, a new antiestrogen drug, against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Tamoxifen in advanced breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Estrogenic regulation of growth and polypeptide growth factor secretion in human breast carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Antiestrogenic properties of keoxifene, trans-4-hydroxytamoxifen, and ICI 164384, a new steroidal antiestrogen, in ZR-75-1 human breast cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Effects of antioestrogens on the proliferation of MCF-7 human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Effect of estrogen and antiestrogens on cell proliferation and synthesis of secreted proteins in the human breast cancer cell line MCF-7 and a tamoxifen resistant variant subline, AL-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Response after withdrawal of tamoxifen and progestogens in advanced breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Clinical significance of tamoxifen withdrawal response

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Combined modality therapy for first recurrence of breast cancer. A Southwest Oncology Group study

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Tamoxifen resistance in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Anti-proliferative and anti-estrogenic effects of ICI 164,384 and ICI 182,780 in 4-OH-tamoxifen-resistant human breast-cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Acquired tamoxifen resistance: correlation with reduced breast tumor levels of tamoxifen and isomerization of trans-4-hydroxytamoxifen.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Endocrine therapy testing of human breast cancers in the soft agar clonogenic assay.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Regulation of pS2 gene expression by affinity labeling and reversibly binding estrogens and antiestrogens: comparison of effects on the native gene and on pS2-chloramphenicol acetyltransferase fusion genes transfected into MCF-7 human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Differential effects of estrogen and antiestrogen on in vitro clonogenic growth of human breast cancers in soft agar.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Effects of 4-hydroxytamoxifen and a novel pure antioestrogen (ICI 182780) on the clonogenic growth of human breast cancer cells in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Comparative studies on the effects of steroidal and nonsteroidal oestrogen antagonists on the proliferation of human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Tamoxifen stimulation of human breast cancer cell proliferation in vitro: a possible model for tamoxifen tumour flare

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Contrasting ability of antiestrogens to inhibit MCF-7 growth stimulated by estradiol or epidermal growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

The pharmacology and clinical uses of tamoxifen

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Potential role of tamoxifen in prevention of breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

A simple and sensitive microtiter plate estrogen bioassay based on stimulation of alkaline phosphatase in Ishikawa cells: estrogenic action of delta 5 adrenal steroids

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Effects of tamoxifen therapy on lipid and lipoprotein levels in postmenopausal patients with node-negative breast cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Effects of tamoxifen on cardiovascular risk factors in postmenopausal women

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

Binding characteristics of novel nonsteroidal antiestrogens to the rat uterine estrogen receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900139-X

7 January 2021

10.1016/S0960-0760(01)00139-X

Identifiers

DOI

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2 August 2017

1 reference