Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus. (Q34540525)

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11 February 2020

title

Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus (English)

1 reference

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11 February 2020

0 references

1 reference

1

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11 February 2020

Subhojit Sen

4

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11 February 2020

10

Stephen B Baylin

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11 February 2020

author name string

Leander Van Neste

2

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11 February 2020

Leslie Cope

3

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11 February 2020

Helai P Mohammad

5

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11 February 2020

Gayle J Pageau

6

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11 February 2020

Jeanne B Lawrence

7

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11 February 2020

James G Herman

8

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11 February 2020

Kornel E Schuebel

9

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11 February 2020

language of work or name

English

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publication date

24 August 2010

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11 February 2020

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11 February 2020

volume

70

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11 February 2020

issue

20

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11 February 2020

page(s)

8015-8024

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Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation

11 February 2020

cites work

1 reference

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Transcription and the nuclear periphery: edge of darkness?

7 July 2018

1 reference

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The meaning of gene positioning

7 July 2018

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Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells

7 July 2018

1 reference

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DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma

7 July 2018

1 reference

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Recruitment to the nuclear periphery can alter expression of genes in human cells

7 July 2018

1 reference

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A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence

7 July 2018

1 reference

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Locus-specific and activity-independent gene repositioning during early tumorigenesis.

7 July 2018

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Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer

7 July 2018

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Comparing the DNA hypermethylome with gene mutations in human colorectal cancer

7 July 2018

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Action at a distance: epigenetic silencing of large chromosomal regions in carcinogenesis

7 July 2018

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Biochemistry meets nuclear architecture: multicolor immuno-FISH for co-localization analysis of chromosome segments and differentially expressed gene loci with various histone methylations.

7 July 2018

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Alterations of centromere positions in nuclei of immortalized and malignant mouse lymphocytes

7 July 2018

1 reference

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Radial chromatin positioning is shaped by local gene density, not by gene expression

7 July 2018

1 reference

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Beyond the sequence: cellular organization of genome function

7 July 2018

1 reference

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The epigenomics of cancer

7 July 2018

1 reference

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Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions

7 July 2018

1 reference

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Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2'-deoxycytidine treatment

7 July 2018

1 reference

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Regional copy number-independent deregulation of transcription in cancer

7 July 2018

1 reference

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Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state

7 July 2018

1 reference

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Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases.

7 July 2018

1 reference

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The 4q subtelomere harboring the FSHD locus is specifically anchored with peripheral heterochromatin unlike most human telomeres

7 July 2018

1 reference

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Active genes dynamically colocalize to shared sites of ongoing transcription

7 July 2018

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The three-dimensional organization of telomeres in the nucleus of mammalian cells

7 July 2018

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Repositioning of Muscle-specific Genes Relative to the Periphery of SC-35 Domains during Skeletal Myogenesis

7 July 2018

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Clustering of multiple specific genes and gene-rich R-bands around SC-35 domains: evidence for local euchromatic neighborhoods

7 July 2018

1 reference

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Inheritance of gene density-related higher order chromatin arrangements in normal and tumor cell nuclei

7 July 2018

1 reference

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Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation

7 July 2018

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An epigenetic road map for histone lysine methylation

7 July 2018

1 reference

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A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

7 July 2018

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DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

7 July 2018

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Gene silencing, cell fate and nuclear organisation

7 July 2018

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The human transcriptome map: clustering of highly expressed genes in chromosomal domains

7 July 2018

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Nuclear structure-gene expression interrelationships: implications for aberrant gene expression in cancer

7 July 2018

1 reference

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Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus

7 July 2018

1 reference

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Differences in the localization and morphology of chromosomes in the human nucleus.

7 July 2018

1 reference

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Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines

7 July 2018

1 reference

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Fluorescent detection of nuclear RNA and DNA: implications for genome organization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031132

The CpG island methylator phenotype correlates with long-range epigenetic silencing in colorectal cancer.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031132

Transcriptional repression mediated by repositioning of genes to the nuclear lamina

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031132

Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031132

Histone lysine methylation patterns in human cell types are arranged in distinct three-dimensional nuclear zones

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031132

Expression of alpha- and beta-globin genes occurs within different nuclear domains in haemopoietic cells.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031132

Local gene density predicts the spatial position of genetic loci in the interphase nucleus

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031132

GoldenGate assay for DNA methylation profiling

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20736368

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-10-0765

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20736368%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20736368%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

20736368

1 reference